PANTHER Gene Information

Gene Symbol(s):

Nepl10

Organism:

Drosophila melanogaster

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Gene Name:

Neprilysin-like 10

Gene ID:

FBgn0033742

Protein ID:

A1Z910

Persistent Id:

PTN000200083

Alternate Ids:

A1Z910_DROME(UniProtKB-ID)	A1Z910(Synonym)
7303447(GI)	NP_610787(refSeq)
AAF58503(EMBL-CDS)	FBgn0033742(Ensembl)
FBtr0087935(Ensembl_TRS)	AE013599(EMBL)
FBgn0033742(FlyBase)	FBpp0087046(Ensembl_PRO)
36366(GeneID)
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PANTHER Classification

PANTHER Family:	ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily:	GH26575P-RELATED (PTHR11733:SF241)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	metalloprotease

Pathway Categories:

Endothelin signaling pathway

Endothelin-coverting enzyme 1, 2, and 3

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	-
GO BP Complete:	proteolysis
GO CC Complete:	plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Muscle contraction, Physiological factors, Immune System, Peptide hormone metabolism, Metabolism of proteins, Innate Immune System, Neutrophil degranulation, Metabolism of Angiotensinogen to Angiotensins, Cardiac conduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8918\|UniProtKB=P78562	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021737.4\|UniProtKB=H2QYE4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000036211.1\|UniProtKB=A0A2I2YJK6	Gorilla gorilla gorilla	O
GORGO\|Ensembl=ENSGGOG00000003961.3\|UniProtKB=G3QMZ2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000023589.4\|UniProtKB=F7HFQ1	Macaca mulatta	O
MOUSE\|MGI=MGI=107489\|UniProtKB=P70669	Mus musculus	O
RAT\|RGD=3323\|UniProtKB=G3V723	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000000419.5\|UniProtKB=E1BKS5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012167.4\|UniProtKB=F1SQ05	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000011455.4\|UniProtKB=F6ZQA0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000023221.4\|UniProtKB=M3WSX1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845029993.1\|UniProtKB=A0A8I3Q891	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000007861.4\|UniProtKB=F7EBG3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000010653.3\|UniProtKB=F6XSA3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003252.1\|UniProtKB=A0A8V0XFU9	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007524.4\|UniProtKB=A0A803TY88	Anolis carolinensis	O
XENLA\|Gene=phex.S\|UniProtKB=A0A1L8H612	Xenopus laevis	O
XENLA\|Gene=phex.L\|UniProtKB=A0A1L8HDK6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1012247\|UniProtKB=A0A6I8RG47	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000014048.2\|UniProtKB=H2MG84	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030103-2\|UniProtKB=F1R6K1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003780.1\|UniProtKB=W5M818	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000014061.2\|UniProtKB=F6PUF3	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000004627.3\|UniProtKB=F6PTZ3	Ciona intestinalis	O
BRAFL\|Gene=LOC118423057\|UniProtKB=A0A9J7N213	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC575956\|UniProtKB=A0A7M7R9K5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00016896\|UniProtKB=O45311	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032164\|UniProtKB=A8XC98	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00032159\|UniProtKB=A8XC93	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00032163\|UniProtKB=A8XC97	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG22755\|UniProtKB=A8Y336	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00281762\|UniProtKB=A0A2A6BU78	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277683\|UniProtKB=A0A2A6BK67	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277699\|UniProtKB=A0A2A6BK74	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277720\|UniProtKB=A0A2A6BJZ4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275378\|UniProtKB=A0A2A6BGH9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00204323\|UniProtKB=A0A2A6BJF9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109121\|UniProtKB=A0A2A6BJY3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109280\|UniProtKB=A0A2A6BJV6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277718\|UniProtKB=A0A2A6BJQ2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00204374\|UniProtKB=A0A2A6BK76	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00014171\|UniProtKB=G5ED52	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG20236\|UniProtKB=A8XXD1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020230\|UniProtKB=O44857	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038760\|UniProtKB=A8XVX0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00095589\|UniProtKB=A0A2A6C3X0	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099366\|UniProtKB=A0A2A6B8W7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00117129\|UniProtKB=A0A2A6B9J9	Pristionchus pacificus	O
ANOGA\|EnsemblGenome=AGAP009791\|UniProtKB=A0A1S4H2V0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC011972\|UniProtKB=D6X2U0	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_192377\|UniProtKB=E9FZ03	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG177711\|UniProtKB=T1FC43	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG175054\|UniProtKB=T1F8S6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG177705\|UniProtKB=T1FC41	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG177709\|UniProtKB=T1FC42	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG187798\|UniProtKB=T1FPD8	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g229362\|UniProtKB=A7S4D9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG37639\|UniProtKB=B3RTH7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63323\|UniProtKB=B3RZU7	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_03091\|UniProtKB=C8VIN1	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G12420\|UniProtKB=Q4WYB2	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_05697\|UniProtKB=A7EK51	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_15353\|UniProtKB=Q0TYS9	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNB04230\|UniProtKB=Q5KLS5	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02693\|UniProtKB=A0A0D1C704	Ustilago maydis	O
THAPS\|EnsemblGenome=THAPSDRAFT_269863\|UniProtKB=B8LCF9	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GEF2_PHYRM\|UniProtKB=H3GEF2	Phytophthora ramorum	O
PHYRM\|Gene=H3HBZ9_PHYRM\|UniProtKB=H3HBZ9	Phytophthora ramorum	O
PHYRM\|Gene=H3H7F1_PHYRM\|UniProtKB=H3H7F1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_000670270\|UniProtKB=A0A1Y1HUV6	Klebsormidium nitens	O
METAC\|EnsemblGenome=MA_2001\|UniProtKB=Q8TPB2	Methanosarcina acetivorans	O
MYCTU\|Gene_OrderedLocusName=Rv0198c\|UniProtKB=I6X8R2	Mycobacterium tuberculosis	O
STRR6\|EnsemblGenome=spr1491\|UniProtKB=Q8DNW9	Streptococcus pneumoniae	O
BACTN\|EnsemblGenome=BT_3811\|UniProtKB=Q8A156	Bacteroides thetaiotaomicron	O
SHEON\|Gene_OrderedLocusName=SO_0429\|UniProtKB=Q8EJN4	Shewanella oneidensis	O
SHEON\|Gene_OrderedLocusName=SO_3844\|UniProtKB=Q8EAQ3	Shewanella oneidensis	O
RHOBA\|EnsemblGenome=RB9029\|UniProtKB=Q7UM68	Rhodopirellula baltica	O
SHEON\|Gene_OrderedLocusName=SO_0491\|UniProtKB=Q8EJH4	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC3671\|UniProtKB=Q8P4N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2710\|UniProtKB=Q8P7A3	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2035\|UniProtKB=Q8P931	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2575\|UniProtKB=Q8P7N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2574\|UniProtKB=Q8P7N7	Xanthomonas campestris	O