PANTHER Gene Information

Gene Symbol(s):

CDC14C

Organism:

Homo sapiens

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Gene Name:

Dual specificity protein phosphatase CDC14C

Gene ID:

HGNC:22427

Protein ID:

A4D256

Enhancers:

View enhancers for HUMAN|HGNC=22427|UniProtKB=A4D256

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002511458

Alternate Ids:

Q8NCT2(AltAccession)	DQ120635(EMBL)
CDC14Bretro(Synonym)	ENSG00000218305(Ensembl)
HGNC:22427(HGNC)	ENSP00000497792(Ensembl_PRO)
269849544(GI)	ABB92421(EMBL-CDS)
CDC14C{ECO:0000312\|HGNC:HGNC:22427}(Symbol)	ENST00000650262(Ensembl_TRS)
CC14C_HUMAN(UniProtKB-ID)	3.1.3.48(EC)
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PANTHER Classification

PANTHER Family:	TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE (PTHR23339)
PANTHER Subfamily:	DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14C (PTHR23339:SF117)
PANTHER GO-slim Molecular Function:	protein serine/threonine phosphatase activity protein tyrosine phosphatase activity
PANTHER GO-slim Biological Process:	cilium assembly regulation of cytokinesis microtubule cytoskeleton organization positive regulation of cell cycle process positive regulation of cell division regulation of mitotic cell cycle phase transition
PANTHER GO-slim Cellular Component:	ciliary basal body mitotic spindle spindle pole kinocilium nucleolus cytoplasm
PANTHER protein class:	protein phosphatase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	calmodulin-dependent protein phosphatase activity, protein serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, metal-dependent, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, MAP kinase serine/threonine phosphatase activity, histone H2AXS140 phosphatase activity, RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity, histone H2AXY142 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, myosin phosphatase activity, RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
GO BP Complete:	chromatin remodeling, cilium assembly, regulation of exit from mitosis, microtubule cytoskeleton organization, positive regulation of cytokinesis, regulation of transcription by RNA polymerase II
GO CC Complete:	endoplasmic reticulum membrane, mitotic spindle, cytoplasm, spindle pole, nucleolus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000048690.1\|UniProtKB=A0A2I3RRW8	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000047431.1\|UniProtKB=A0A2I3T3I7	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000027917.2\|UniProtKB=G3RR83	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008002.3\|UniProtKB=A0A1D5QHC5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2441808\|UniProtKB=Q6PFY9	Mus musculus	O
RAT\|RGD=1311163\|UniProtKB=A0A8I5YC46	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011589.6\|UniProtKB=A0A3Q1N5B2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000027557.4\|UniProtKB=A0A286ZK37	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000029122.3\|UniProtKB=A0A9L0TGJ8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000024293.4\|UniProtKB=A0A337SP80	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845003296.1\|UniProtKB=A0A8I3MKA6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000012388.3\|UniProtKB=F7BZ82	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000000544.4\|UniProtKB=F6XN43	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010010844.1\|UniProtKB=A0A1D5PXT4	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000012788.4\|UniProtKB=A0A803T948	Anolis carolinensis	O
XENLA\|Gene=cdc14b.S\|UniProtKB=A0A8J1LMV0	Xenopus laevis	O
XENLA\|Gene=cdc14b.L\|UniProtKB=A0A8J0V493	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-977314\|UniProtKB=A4IJ03	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000003939.3\|UniProtKB=A0A3B3IE46	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000009181.1\|UniProtKB=W5MS44	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000007516.3\|UniProtKB=F6UJI9	Ciona intestinalis	O
BRAFL\|Gene=LOC118431778\|UniProtKB=A0A9J7MD02	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115918471\|UniProtKB=A0A7M7SW78	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000383\|UniProtKB=P81299	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02450\|UniProtKB=A8WUA9	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG02452\|UniProtKB=A8WUA7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00112238\|UniProtKB=A0A2A6B9B7	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0031952\|UniProtKB=Q9VLW7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029670\|UniProtKB=A0A453Z0L5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC008603\|UniProtKB=D6WTN6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC001964\|UniProtKB=A0A139WA89	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_201727\|UniProtKB=E9HA32	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW000542\|UniProtKB=B7P3Q9	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG188439\|UniProtKB=T1FPZ6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG91786\|UniProtKB=T1G889	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG77242\|UniProtKB=T1G2U9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210849\|UniProtKB=A7SE41	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g11161\|UniProtKB=A7SDJ9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG27920\|UniProtKB=B3S2H1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_33516\|UniProtKB=A9V5U2	Monosiga brevicollis	O
YEAST\|SGD=S000001924\|UniProtKB=Q00684	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AEL025W\|UniProtKB=Q757N7	Eremothecium gossypii	O
CANAL\|CGD=CAL0000180943\|UniProtKB=Q59NH8	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E16038g\|UniProtKB=Q6C5Q7	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_05057\|UniProtKB=Q5B323	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G12250\|UniProtKB=Q4WY95	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03246\|UniProtKB=Q7SCM5	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_12669\|UniProtKB=A7F4Z4	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_10769\|UniProtKB=Q0UBU5	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC1782.09c\|UniProtKB=Q9P7H1	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00082\|UniProtKB=B6JUY3	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNA04770\|UniProtKB=Q5KNZ4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_06187\|UniProtKB=A0A0D1BUL5	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_13987\|UniProtKB=E3KTJ1	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_22794\|UniProtKB=F4NXK9	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_09_0420\|UniProtKB=Q4QHY2	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.4270\|UniProtKB=Q382T8	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_9270\|UniProtKB=A8BAI9	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_362610\|UniProtKB=A2E639	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_168700\|UniProtKB=A2FHE7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_458950\|UniProtKB=A2E6A0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_490830\|UniProtKB=A2E026	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_479730\|UniProtKB=A2F8F0	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00024658001\|UniProtKB=A0E9G0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030541001\|UniProtKB=A0BMY7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010135001\|UniProtKB=A0CSU6	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_14971\|UniProtKB=B8LD57	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9E5_PHYRM\|UniProtKB=H3G9E5	Phytophthora ramorum	O
PHYRM\|Gene=H3G5J9_PHYRM\|UniProtKB=H3G5J9	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_02g105400v5\|UniProtKB=A0A2K3E2J4	Chlamydomonas reinhardtii	O
TOBAC\|Gene=LOC107822933\|UniProtKB=A0A1S4CUV2	Nicotiana tabacum	O
SELML\|EnsemblGenome=SELMODRAFT_91859\|UniProtKB=D8RE91	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_3248\|UniProtKB=D8STT9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c27_7750\|UniProtKB=A0A7I4CZ80	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0079s0039\|UniProtKB=A0A2R6WKZ6	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001630070\|UniProtKB=A0A1Y1I320	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_1760\|UniProtKB=A9A3V6	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_0177\|UniProtKB=B1L3A8	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_0609\|UniProtKB=B1L4I3	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO2453\|UniProtKB=Q97VZ7	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1536\|UniProtKB=Q8ZX04	Pyrobaculum aerophilum	O
METJA\|EnsemblGenome=MJ_ECL20\|UniProtKB=Q60280	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_0215\|UniProtKB=Q57668	Methanocaldococcus jannaschii	O
THEKO\|EnsemblGenome=TK0241\|UniProtKB=Q8X270	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_0153\|UniProtKB=A9WBK0	Chloroflexus aurantiacus	O
DEIRA\|EnsemblGenome=DR_2161\|UniProtKB=Q9RSG3	Deinococcus radiodurans	O
GLOVI\|Gene=Q7NLX9_GLOVI\|UniProtKB=Q7NLX9	Gloeobacter violaceus	O
SHEON\|Gene_OrderedLocusName=SO_0090\|UniProtKB=Q8EKK2	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1070\|UniProtKB=Q9KT35	Vibrio cholerae	O