PANTHER Gene Information

Gene Symbol(s):

NEU1

Organism:

Bos taurus

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Gene Name:

Sialidase-1

Gene ID:

ENSBTAG00000005674

Protein ID:

A6BMK7

Persistent Id:

PTN007450595

Alternate Ids:

AB327106(EMBL)	NEUR1_BOVIN(UniProtKB-ID)
NM_001083642(refSeq)	Q5D0G1(AltAccession)
149676186(GI)	3.2.1.18(EC)
Lysosomal sialidase(Synonym)	505554(GeneID)
AAX14675(EMBL-CDS)	ENSBTAG00000005674(Ensembl)
NEU1(Symbol)	ENSBTAP00000007454(Ensembl_PRO)
ENSBTAT00000007454(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	SIALIDASE (PTHR10628)
PANTHER Subfamily:	SIALIDASE-1 (PTHR10628:SF25)
PANTHER GO-slim Molecular Function:	hydrolase activity, hydrolyzing O-glycosyl compounds
PANTHER GO-slim Biological Process:	carbohydrate derivative catabolic process ceramide metabolic process sphingolipid catabolic process glycolipid metabolic process carbohydrate catabolic process
PANTHER GO-slim Cellular Component:	cytoplasm intracellular membrane-bounded organelle membrane
PANTHER protein class:	hydrolase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	exo-alpha-sialidase activity
GO BP Complete:	oligosaccharide catabolic process, ganglioside catabolic process
GO CC Complete:	cytoplasm, membrane, cytoplasmic vesicle, lysosomal lumen, lysosomal membrane, plasma membrane, lysosome

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Glycosphingolipid catabolism, Post-translational protein modification, Metabolism of proteins, Neutrophil degranulation, Glycosphingolipid metabolism, Synthesis of substrates in N-glycan biosythesis, Immune System, Sphingolipid metabolism, Metabolism of lipids, Asparagine N-linked glycosylation, Metabolism, Innate Immune System, Sialic acid metabolism, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7758\|UniProtKB=Q99519	Homo sapiens	LDO
MACMU\|Ensembl=ENSMMUG00000021707.4\|UniProtKB=F7EZS0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=97305\|UniProtKB=O35657	Mus musculus	LDO
RAT\|RGD=3163\|UniProtKB=Q99PW3	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000001418.5\|UniProtKB=F1RQX3	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00070023485\|UniProtKB=A5PF10	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000024446.4\|UniProtKB=M3X3Z7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845013021.1\|UniProtKB=A0A8I3NN43	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000050558.1\|UniProtKB=A0A6I8NGP9	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000012147.3\|UniProtKB=G1KLY3	Anolis carolinensis	LDO
XENLA\|Gene=neu1.L\|UniProtKB=A0A1L8F8G4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-959028\|UniProtKB=F6WK48	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002057.2\|UniProtKB=H2L9M4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-060503-592\|UniProtKB=Q1LWP9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007818.1\|UniProtKB=W5MM81	lepisosteus oculatus	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_86823\|UniProtKB=C3Y2L4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421330\|UniProtKB=A0A9J7LK79	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419529\|UniProtKB=A0A9J7MWY5	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421338\|UniProtKB=A0A9J7LLR0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421704\|UniProtKB=A0A9J7LLH2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421326\|UniProtKB=K0Q6T4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421322\|UniProtKB=A0A9J7LKG3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421323\|UniProtKB=A0A9J7LMG4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421335\|UniProtKB=A0A9J7LME1	Branchiostoma floridae	LDO
BRAFL\|Gene=LOC118421792\|UniProtKB=A0A9J7LNT0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421327\|UniProtKB=A0A9J7MZF3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421329\|UniProtKB=K0Q1U9	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421341\|UniProtKB=A0A9J7LME8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421310\|UniProtKB=A0A9J7MWT1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421333\|UniProtKB=A0A9J7LKH2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421700\|UniProtKB=A0A9J7LLH7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100890176\|UniProtKB=A0A7M7NLG3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100890097\|UniProtKB=A0A7M7GG24	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105446099\|UniProtKB=A0A7M7NNL4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100890017\|UniProtKB=A0A7M7NL73	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115922781\|UniProtKB=A0A7M7NR48	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC585449\|UniProtKB=A0A7M7RFJ3	Strongylocentrotus purpuratus	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210903\|UniProtKB=A7SE79	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_22854\|UniProtKB=A9US97	Monosiga brevicollis	LDO
ASPFU\|EnsemblGenome=AFUA_4G13800\|UniProtKB=Q4WQS0	Neosartorya fumigata	O
TRYB2\|Gene_ORFName=Tb927.7.6830\|UniProtKB=Q57Y46	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb11.01.3240\|UniProtKB=Q383D7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.8.7340\|UniProtKB=Q57YT6	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.7.6850\|UniProtKB=Q57XJ2	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.7.7480\|UniProtKB=Q57TY5	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.8.7350\|UniProtKB=Q57YT7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.2.5280\|UniProtKB=Q585U3	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.5.640\|UniProtKB=Q57VF2	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_301370\|UniProtKB=A2E5F9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_499550\|UniProtKB=A2EIP2	Trichomonas vaginalis	O
BACTN\|EnsemblGenome=BT_3608\|UniProtKB=Q8A1Q1	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB3006\|UniProtKB=Q7UUX1	Rhodopirellula baltica	O
STRR6\|EnsemblGenome=spr1531\|UniProtKB=Q8CWP8	Streptococcus pneumoniae	O
STRR6\|EnsemblGenome=spr1536\|UniProtKB=P62576	Streptococcus pneumoniae	O
BACTN\|EnsemblGenome=BT_0455\|UniProtKB=Q8AAK9	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB8895\|UniProtKB=Q7UMD4	Rhodopirellula baltica	O
VIBCH\|EnsemblGenome=VC_1784\|UniProtKB=P0C6E9	Vibrio cholerae	O
PSEAE\|EnsemblGenome=PA2794\|UniProtKB=G3XCV3	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0928\|UniProtKB=P29768	Salmonella typhimurium	O