PANTHER Gene Information

Gene Symbol(s):

impdh2

Organism:

Danio rerio

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Gene Name:

Inosine-5'-monophosphate dehydrogenase 2

Gene ID:

ZDB-GENE-030114-5

Protein ID:

B0UXP9

Persistent Id:

PTN000226968

Alternate Ids:

ZDB-GENE-030114-5(ZFIN)	CR382331(EMBL)
IMDH2_DANRE(UniProtKB-ID)	378548384(GI)
IMPD 2 {ECO:0000255\|HAMAP-Rule:MF_03156}(Synonym)	impdh2(Symbol)
1.1.1.205 {ECO:0000250\|UniProtKB:P12268}(EC)	CAQ13978(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED (PTHR11911)
PANTHER Subfamily:	INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 (PTHR11911:SF121)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:	purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	dehydrogenase

Pathway Categories:

De novo purine biosynthesis

IMP dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	nucleotide binding, catalytic activity, oxidoreductase activity, metal ion binding, IMP dehydrogenase activity
GO BP Complete:	purine nucleotide biosynthetic process, GTP biosynthetic process, GMP biosynthetic process, circadian rhythm
GO CC Complete:	nucleus, cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Azathioprine ADME, Drug ADME, Immune System, Neutrophil degranulation, Innate Immune System, Nucleotide biosynthesis, Metabolism, Metabolism of nucleotides, Purine ribonucleoside monophosphate biosynthesis

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6053\|UniProtKB=P12268	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000014908.5\|UniProtKB=H2R178	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013245.3\|UniProtKB=G3RBQ8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005656.4\|UniProtKB=F6VXT4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109367\|UniProtKB=P24547	Mus musculus	LDO
RAT\|RGD=735092\|UniProtKB=E9PU28	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000031837\|UniProtKB=Q3SWY3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000011373.5\|UniProtKB=A0A287BMK8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006885.4\|UniProtKB=A0A9L0RH24	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009844.6\|UniProtKB=M3WC84	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029196.1\|UniProtKB=A0A8I3Q7R1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000013354.2\|UniProtKB=F7DTY4	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010907.3\|UniProtKB=F6ZLV0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010020638.1\|UniProtKB=A0A1D5PSI2	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012452.4\|UniProtKB=A0A803T7N8	Anolis carolinensis	LDO
XENLA\|Gene=impdh2.S\|UniProtKB=A0A8J1MZF9	Xenopus laevis	O
XENLA\|Gene=impdh2.L\|UniProtKB=A0A8J0UZ33	Xenopus laevis	LDO
XENTR\|Gene=impdh2\|UniProtKB=F7CYY5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002914.2\|UniProtKB=A0A3B3H834	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000014390.1\|UniProtKB=W5NAR4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007078.3\|UniProtKB=F6USH9	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118415340\|UniProtKB=A0A9J7L472	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC752101\|UniProtKB=A0A7M7PXW9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00020682\|UniProtKB=Q9GZH3	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00028113\|UniProtKB=A8X1T4	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00095074\|UniProtKB=A0A2A6CAQ1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0003204\|UniProtKB=Q07152	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP011133\|UniProtKB=A0A1S4H5T8	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC005099\|UniProtKB=D2CFZ3	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_218652\|UniProtKB=E9HL84	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW001657\|UniProtKB=B7P4Q8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG186209\|UniProtKB=T1FNT6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g236271\|UniProtKB=A7REY1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g177384\|UniProtKB=A7RG06	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG50297\|UniProtKB=B3RXY8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38942\|UniProtKB=A9VB34	Monosiga brevicollis	LDO
YEAST\|SGD=S000001259\|UniProtKB=P38697	Saccharomyces cerevisiae	O
YEAST\|SGD=S000004520\|UniProtKB=P50094	Saccharomyces cerevisiae	LDO
YEAST\|SGD=S000004424\|UniProtKB=P50095	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AER117W\|UniProtKB=Q756Z6	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000175344\|UniProtKB=Q59Q46	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D21530g\|UniProtKB=Q6C897	Yarrowia lipolytica	LDO
ASPFU\|EnsemblGenome=AFUA_2G03610\|UniProtKB=Q4WHZ9	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU03117\|UniProtKB=Q7SFX7	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_12054\|UniProtKB=A7F2A7	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_00421\|UniProtKB=Q0V6E3	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC2F12.14c\|UniProtKB=O14344	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01298\|UniProtKB=B6K0A5	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA04240\|UniProtKB=Q5KP44	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10276\|UniProtKB=A0A0D1CRJ0	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_08884\|UniProtKB=E3KEF5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_12346\|UniProtKB=F4P5T8	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0283701\|UniProtKB=Q54QQ0	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_94457\|UniProtKB=F0ZJQ3	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_19_1560\|UniProtKB=Q4QD53	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb10.61.0150\|UniProtKB=Q387Q3	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_0920800\|UniProtKB=Q8I2U5	Plasmodium falciparum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_268688\|UniProtKB=B8BZC2	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GAR8_PHYRM\|UniProtKB=H3GAR8	Phytophthora ramorum	O
PHYRM\|Gene=H3G9N6_PHYRM\|UniProtKB=H3G9N6	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_14g614300v5\|UniProtKB=A8JAP7	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00002p00088870\|UniProtKB=W1NZ84	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_279G00140\|UniProtKB=A0A0K9PDT6	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma11_g21660\|UniProtKB=A0A804LAE7	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma05_g20350\|UniProtKB=A0A804J6K4	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_029593mg\|UniProtKB=K3ZSL3	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3002G029600\|UniProtKB=C5X9F2	Sorghum bicolor	O
SETIT\|EnsemblGenome=SETIT_035318mg\|UniProtKB=K4A8W2	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3001G069900\|UniProtKB=C5WZ26	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb057300\|UniProtKB=A0A1D6L4K3	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb059650\|UniProtKB=C4J306	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os03g0780500\|UniProtKB=Q10CU7	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g06810v3\|UniProtKB=I1GMN6	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.5HG0514980\|UniProtKB=A0A8I6YCT4	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS5D02G424000\|UniProtKB=A0A3B6MZ83	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5A02G416300\|UniProtKB=A0A3B6KR09	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS5B02G418600\|UniProtKB=A0A3B6LUD2	Triticum aestivum	LDO
NELNU\|Gene=LOC104613005\|UniProtKB=A0A1U8BP90	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110805358\|UniProtKB=A0A9R0JEM5	Spinacia oleracea	O
SPIOL\|Gene=LOC110779335\|UniProtKB=A0A9R0HYN8	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0629671\|UniProtKB=A0A251SF08	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0610601\|UniProtKB=A0A251SWD7	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C600316830\|UniProtKB=A0A9R1VBN4	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C300148070\|UniProtKB=A0A9R1W5J6	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a004663mg\|UniProtKB=A0A022QM83	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_26564\|UniProtKB=A0A2G2YNZ6	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400008158\|UniProtKB=M1AEK1	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc10g079500.2\|UniProtKB=A0A3Q7IKJ5	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107775294\|UniProtKB=A0A1S3YES5	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi19g01733\|UniProtKB=F6H9U0	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_E02909\|UniProtKB=A0A059C7C8	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_I02089\|UniProtKB=A0A059ASG1	Eucalyptus grandis	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_L02511\|UniProtKB=A0A058ZRL6	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra035121\|UniProtKB=M4F224	Brassica campestris	O
ARATH\|TAIR=locus=2206365\|UniProtKB=P47996	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=DARMORV10_A06P12260.1\|UniProtKB=A0A078HCA2	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C05P14510.1\|UniProtKB=A0A078H7D0	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra026064\|UniProtKB=M4EBA5	Brassica campestris	LDO
ARATH\|TAIR=locus=2032775\|UniProtKB=Q9SA34	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107937201\|UniProtKB=A0A1U8MFJ4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107938614\|UniProtKB=A0A1U8MNZ9	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_036938\|UniProtKB=A0A061GHN8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g010640mg\|UniProtKB=A0A067F2L2	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_010G173600v3\|UniProtKB=B9HYB2	Populus trichocarpa	LDO
POPTR\|EnsemblGenome=POPTR_008G082800v3\|UniProtKB=A0A2K1ZDW9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_03G079800\|UniProtKB=A0A2C9W5P3	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1425680\|UniProtKB=B9RRP5	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_15G263100\|UniProtKB=I1MJD7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G164100\|UniProtKB=I1KTW9	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_7g085560\|UniProtKB=G7KZG9	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr02_07640\|UniProtKB=A0A2I4FI19	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_7G239630\|UniProtKB=A0A0A0K923	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_4G129200\|UniProtKB=M5X1V1	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_165452\|UniProtKB=D8QUP9	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c1_34070\|UniProtKB=A9RU40	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c1_34170\|UniProtKB=A0A2K1LAV0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c14_26610\|UniProtKB=A9TN21	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0102s0045\|UniProtKB=A0A2R6WE98	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000790120\|UniProtKB=A0A1Y1HXW7	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1569\|UniProtKB=A9A5Y7	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_1078\|UniProtKB=B1L5U5	Korarchaeum cryptofilum	LDO
METJA\|EnsemblGenome=MJ_1616\|UniProtKB=Q59011	Methanocaldococcus jannaschii	LDO
HALSA\|EnsemblGenome=VNG_1001G\|UniProtKB=Q9HQU4	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK0194\|UniProtKB=Q5JFM0	Thermococcus kodakaraensis	LDO
STRCO\|Gene_OrderedLocusName=SCO4771\|UniProtKB=Q9L0I6	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3410c\|UniProtKB=P9WKI5	Mycobacterium tuberculosis	O
GLOVI\|Gene=Q7NK75_GLOVI\|UniProtKB=Q7NK75	Gloeobacter violaceus	O
CHLAA\|EnsemblGenome=Caur_0616\|UniProtKB=A9WEU7	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO4770\|UniProtKB=Q9L0I7	Streptomyces coelicolor	LDO
MYCTU\|Gene_OrderedLocusName=Rv3411c\|UniProtKB=P9WKI7	Mycobacterium tuberculosis	LDO
CLOBH\|Gene_OrderedLocusName=CBO3296\|UniProtKB=A5I721	Clostridium botulinum	LDO
STRR6\|EnsemblGenome=spr2033\|UniProtKB=Q8DMX2	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_00374\|UniProtKB=Q2G0Y7	Staphylococcus aureus	LDO
LISMO\|Gene=Q8YAJ3_LISMO\|UniProtKB=Q8YAJ3	Listeria monocytogenes	O
LISMO\|Gene=guaB\|UniProtKB=Q926Y9	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_00090\|UniProtKB=P21879	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_0013\|UniProtKB=Q81JC8	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_1347\|UniProtKB=Q9X168	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_1878\|UniProtKB=Q9RT87	Deinococcus radiodurans	LDO
BACTN\|EnsemblGenome=BT_3845\|UniProtKB=Q8A126	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB11822\|UniProtKB=Q7UJL3	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_2023\|UniProtKB=O67820	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A0206\|UniProtKB=B5YHZ0	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_0749\|UniProtKB=B8DZU8	Dictyoglomus turgidum	LDO
FUSNN\|EnsemblGenome=FN1231\|UniProtKB=Q8RE86	Fusobacterium nucleatum	LDO
HELPY\|EnsemblGenome=HP_0829\|UniProtKB=P56088	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB1201\|UniProtKB=Q9JZB5	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU2195\|UniProtKB=Q74B47	Geobacter sulfurreducens	LDO
BRADU\|Gene=guaB\|UniProtKB=Q89N70	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1342\|UniProtKB=Q83BZ5	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0221\|UniProtKB=P44334	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_3293\|UniProtKB=Q8EC51	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0767\|UniProtKB=Q9KTW3	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC2184\|UniProtKB=Q8P8Q5	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA3770\|UniProtKB=Q9HXM5	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM2511\|UniProtKB=Q8ZN59	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_2737\|UniProtKB=Q0WD32	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA16395\|UniProtKB=P0ADG7	Escherichia coli	LDO