PANTHER Gene Information   
Gene Symbol(s): Rnf168
Organism: Rattus norvegicus
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Gene Name: E3 ubiquitin-protein ligase RNF168
Gene ID: 1585168
Protein ID: B2RYR0
Persistent Id: PTN000595983
Alternate Ids:
RN168_RAT(UniProtKB-ID) 1585168(RGD)
2.3.2.27 {ECO:0000255|HAMAP-Rule:MF_03066}(EC) NP_001121069(refSeq)
AAI66869(EMBL-CDS) 187469491(GI)
Rnf168{ECO:0000255|HAMAP-Rule:MF_03066}(Symbol) BC166869(EMBL)
690043(GeneID) RING-type E3 ubiquitin transferase RNF168(Synonym)
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PANTHER Classification
PANTHER Family: RING-TYPE DOMAIN-CONTAINING PROTEIN (PTHR23328)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE RNF168 (PTHR23328:SF1)  
PANTHER GO-slim Molecular Function: nucleosome binding
ubiquitin-protein transferase activity
PANTHER GO-slim Biological Process: double-strand break repair
PANTHER GO-slim Cellular Component: site of double-strand break
nucleus
PANTHER protein class:
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: histone H2AK15 ubiquitin ligase activity, ubiquitin-protein transferase activity, ubiquitin binding, histone binding, metal ion binding, K63-linked polyubiquitin modification-dependent protein binding, nucleosome binding, histone ubiquitin ligase activity, chromatin binding
GO BP Complete: positive regulation of DNA repair, biological_process, negative regulation of transcription elongation by RNA polymerase II, regulation of protein localization, double-strand break repair via nonhomologous end joining, DNA damage response, epigenetic regulation of gene expression, double-strand break repair, ubiquitin-dependent protein catabolic process, double-strand break repair via classical nonhomologous end joining, cellular response to UV, DNA repair-dependent chromatin remodeling, protein K63-linked ubiquitination, response to ionizing radiation, protein ubiquitination, isotype switching
GO CC Complete: nucleus, site of double-strand break, ubiquitin ligase complex, cytosol, protein-containing complex, DNA repair complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: G2/M DNA damage checkpoint, DNA Repair, Cell Cycle, Cell Cycle Checkpoints, Metabolism of proteins, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, G2/M Checkpoints, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), DNA Double-Strand Break Repair, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SUMO E3 ligases SUMOylate target proteins, Homology Directed Repair, SUMOylation of DNA damage response and repair proteins, SUMOylation, DNA Double Strand Break Response, Processing of DNA double-strand break ends

Orthologs