PANTHER Gene Information   
Gene Symbol(s): Traf2
Organism: Rattus norvegicus
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Gene Name: TNF receptor-associated factor
Gene ID: 1310457
Protein ID: B5DFH7
Persistent Id: PTN000015014
Alternate Ids:
B5DFH7_RAT(UniProtKB-ID) NM_001107815(refSeq)
1310457(RGD) ENSRNOP00000008253(Ensembl_PRO)
ENSRNOT00000008253(Ensembl_TRS) 311786(GeneID)
ENSRNOG00000006238(Ensembl) B5DFH7(Synonym)
157821941(GI)
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PANTHER Classification
PANTHER Family: TNF RECEPTOR ASSOCIATED FACTOR (PTHR10131)
PANTHER Subfamily: TNF RECEPTOR-ASSOCIATED FACTOR 2 (PTHR10131:SF21)  
PANTHER GO-slim Molecular Function: ubiquitin-protein transferase activity
tumor necrosis factor receptor binding
PANTHER GO-slim Biological Process: positive regulation of canonical NF-kappaB signal transduction
positive regulation of NF-kappaB transcription factor activity
PANTHER GO-slim Cellular Component: cytoplasmic side of plasma membrane
plasma membrane signaling receptor complex
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: p53 pathway
   TNF receptor-associated factor
Apoptosis signaling pathway
   TNF receptor-associated factor 2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, zinc ion binding, identical protein binding, ubiquitin protein ligase activity, protein phosphatase binding, signaling adaptor activity, CD40 receptor binding, tumor necrosis factor receptor binding, protein-containing complex binding, sphingolipid binding, ubiquitin-protein transferase activity, protein binding, ubiquitin protein ligase binding, tumor necrosis factor binding, mitogen-activated protein kinase kinase kinase binding, thioesterase binding, protein-macromolecule adaptor activity, enzyme binding
GO BP Complete: positive regulation of JUN kinase activity, positive regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of glial cell apoptotic process, signal transduction involved in regulation of gene expression, T cell activation, positive regulation of canonical NF-kappaB signal transduction, TORC1 complex assembly, positive regulation of DNA-binding transcription factor activity, positive regulation of NF-kappaB transcription factor activity, programmed necrotic cell death, interleukin-17-mediated signaling pathway, regulation of immunoglobulin production, cellular response to nitric oxide, CD27 signaling pathway, positive regulation of interleukin-2 production, protein autoubiquitination, TORC2 complex disassembly, protein-containing complex assembly, signal transduction, protein catabolic process, non-canonical NF-kappaB signal transduction, regulation of protein-containing complex assembly, regulation of apoptotic process, regulation of JNK cascade, CD40 signaling pathway, tumor necrosis factor-mediated signaling pathway, innate immune response, positive regulation of T cell cytokine production, mRNA stabilization, protein K63-linked ubiquitination, positive regulation of extrinsic apoptotic signaling pathway
GO CC Complete: cytoplasmic side of plasma membrane, TRAF2-GSTP1 complex, ubiquitin ligase complex, cytoplasm, cell cortex, vesicle membrane, membrane raft, tumor necrosis factor receptor superfamily complex, cytosol, IRE1-TRAF2-ASK1 complex, protein-containing complex, plasma membrane signaling receptor complex, CD40 receptor complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Death Receptor Signaling, Deubiquitination, Interleukin-1 signaling, Apoptosis, Toll Like Receptor 4 (TLR4) Cascade, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor 7/8 (TLR7/8) Cascade, TNFR2 non-canonical NF-kB pathway, CASP8 activity is inhibited, Regulation of NF-kappa B signaling, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Signaling by Interleukins, Interleukin-1 family signaling, RIPK1-mediated regulated necrosis, TNFR1-induced NF-kappa-B signaling pathway, TNF signaling, Innate Immune System, Dimerization of procaspase-8, TAK1-dependent IKK and NF-kappa-B activation , Caspase activation via Death Receptors in the presence of ligand, Ub-specific processing proteases, TRIF(TICAM1)-mediated TLR4 signaling , MyD88 cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Signal Transduction, MyD88-independent TLR4 cascade , Regulation of necroptotic cell death, Metabolism of proteins, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, Post-translational protein modification, Regulation by c-FLIP, Toll Like Receptor 5 (TLR5) Cascade, Regulated Necrosis, Regulation of TNFR1 signaling, Immune System, Toll Like Receptor TLR1:TLR2 Cascade, Caspase activation via extrinsic apoptotic signalling pathway, Toll Like Receptor 9 (TLR9) Cascade, Programmed Cell Death, Toll-like Receptor Cascades, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 2 (TLR2) Cascade, TNFR1-induced proapoptotic signaling, Cytokine Signaling in Immune system

Orthologs