PANTHER Gene Information   
Gene Symbol(s): Atm
Organism: Rattus norvegicus
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Gene Name: Serine-protein kinase ATM
Gene ID: 1593265
Protein ID: D4ACL8
Persistent Id: PTN000124449
Alternate Ids:
300711(GeneID) D4ACL8_RAT(UniProtKB-ID)
1593265(RGD) ENSRNOP00000045529(Ensembl_PRO)
D4ACL8(Synonym) ENSRNOT00000050555(Ensembl_TRS)
157818713(GI) ENSRNOG00000029773(Ensembl)
NP_001100291(refSeq)
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PANTHER Classification
PANTHER Family: ATAXIA TELANGIECTASIA MUTATED ATM -RELATED (PTHR11139)
PANTHER Subfamily: SERINE-PROTEIN KINASE ATM (PTHR11139:SF72)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
PANTHER GO-slim Biological Process: telomere maintenance
DNA damage checkpoint signaling
DNA repair
PANTHER GO-slim Cellular Component: chromosome
nucleus
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: p53 pathway feedback loops 2
   ataxia telangiectasia mutated
p53 pathway
   Ataxia telangiectasia mutated (ATM) and Rad3-related (ATR)
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA-dependent protein kinase activity, ATP binding, identical protein binding, protein kinase activity, histone H2AXS139 kinase activity, protein serine/threonine kinase activity, 1-phosphatidylinositol-3-kinase activity, protein-containing complex binding
GO BP Complete: mitotic spindle assembly checkpoint signaling, female gamete generation, DNA repair, mitotic G2 DNA damage checkpoint signaling, determination of adult lifespan, post-embryonic development, phosphatidylinositol-3-phosphate biosynthetic process, signal transduction in response to DNA damage, female gonad development, response to hypoxia, regulation of cell cycle, neuron apoptotic process, response to ionizing radiation, positive regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of TORC1 signaling, female meiotic nuclear division, male meiotic nuclear division, pexophagy, intrinsic apoptotic signaling pathway in response to DNA damage, brain development, DNA damage response, pre-B cell allelic exclusion, immune system process, regulation of microglial cell activation, establishment of RNA localization to telomere, DNA damage checkpoint signaling, meiotic telomere clustering, cellular response to gamma radiation, cellular response to X-ray, establishment of protein-containing complex localization to telomere, somitogenesis, positive regulation of gene expression, histone mRNA catabolic process, regulation of autophagy, cellular response to reactive oxygen species, positive regulation of cell migration, multicellular organism growth, replicative senescence, negative regulation of telomere capping, positive regulation of cell adhesion, positive regulation of telomere maintenance via telomere lengthening, positive regulation of transcription by RNA polymerase II, lipoprotein catabolic process, chromosome organization involved in meiotic cell cycle, positive regulation of neuron apoptotic process, double-strand break repair, thymus development, positive regulation of DNA catabolic process, heart development, chromatin remodeling, negative regulation of B cell proliferation, cellular response to ionizing radiation, V(D)J recombination, DNA double-strand break processing, positive regulation of telomerase catalytic core complex assembly, double-strand break repair via homologous recombination, telomere maintenance, ovarian follicle development, oocyte development, cellular response to retinoic acid, positive regulation of apoptotic process, positive regulation of telomere maintenance via telomerase, regulation of telomere maintenance via telomerase, cellular response to nitrosative stress
GO CC Complete: site of double-strand break, DNA repair complex, peroxisomal matrix, nucleolus, nucleoplasm, extrinsic component of synaptic vesicle membrane, chromosome, telomeric region, nucleus, centrosome, cytoplasm, intracellular membrane-bounded organelle, spindle, cytoplasmic vesicle
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Stabilization of p53, p53-Dependent G1 DNA Damage Response, Selective autophagy, Cellular Senescence, DNA Damage/Telomere Stress Induced Senescence, Cellular responses to stress, Cell Cycle Checkpoints, Cellular responses to stimuli, HDR through Single Strand Annealing (SSA), p53-Dependent G1/S DNA damage checkpoint, G2/M Checkpoints, Regulation of TP53 Expression and Degradation, Regulation of TP53 Activity through Methylation, Homologous DNA Pairing and Strand Exchange, DNA Double-Strand Break Repair, Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, G1/S DNA Damage Checkpoints, Resolution of D-Loop Structures, Autophagy, Transcriptional Regulation by TP53, Regulation of TP53 Activity, Gene expression (Transcription), TP53 Regulates Transcription of Cell Death Genes, HDR through Homologous Recombination (HRR), G2/M DNA damage checkpoint, DNA Repair, Cell Cycle, Pexophagy, Nonhomologous End-Joining (NHEJ), RNA Polymerase II Transcription, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Resolution of D-loop Structures through Holliday Junction Intermediates, Generic Transcription Pathway, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Macroautophagy, Autodegradation of the E3 ubiquitin ligase COP1, Sensing of DNA Double Strand Breaks, TP53 Regulates Transcription of Caspase Activators and Caspases, Regulation of TP53 Degradation, DNA Double Strand Break Response, Regulation of TP53 Activity through Phosphorylation, Processing of DNA double-strand break ends, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Orthologs