PANTHER Gene Information

Gene Symbol(s):

Hecw2

Organism:

Rattus norvegicus

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Gene Name:

HECT-type E3 ubiquitin transferase

Gene ID:

1593244

Protein ID:

D4ADD3

Persistent Id:

PTN000134794

Alternate Ids:

1593244(RGD)	ENSRNOT00000017761(Ensembl_TRS)
316395(GeneID)	ENSRNOP00000017761(Ensembl_PRO)
157817476(GI)	ENSRNOG00000013257(Ensembl)
D4ADD3_RAT(UniProtKB-ID)	NM_001108218(refSeq)
D4ADD3(Synonym)
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PANTHER Classification

PANTHER Family:	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE (PTHR11254)
PANTHER Subfamily:	E3 UBIQUITIN-PROTEIN LIGASE HECW2 (PTHR11254:SF127)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase activity
PANTHER GO-slim Biological Process:	negative regulation of molecular function ubiquitin-dependent protein catabolic process protein ubiquitination negative regulation of monoatomic ion transport regulation of anatomical structure morphogenesis negative regulation of cellular process regulation of dendrite development regulation of sodium ion transmembrane transporter activity
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ubiquitin protein ligase activity
GO BP Complete:	regulation of mitotic metaphase/anaphase transition, regulation of dendrite morphogenesis, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete:	mitotic spindle, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Class I MHC mediated antigen processing & presentation, Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Adaptive Immune System

Orthologs

ID	Organism	Type
HUMAN\|HGNC=29853\|UniProtKB=Q9P2P5	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012764.4\|UniProtKB=H2QJ66	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013295.3\|UniProtKB=G3RBW6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000005627.4\|UniProtKB=G7N8J7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2685817\|UniProtKB=Q6I6G8	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000020696.6\|UniProtKB=F1N645	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000055181.1\|UniProtKB=A0A8W4FN02	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000544.4\|UniProtKB=A0A9L0RZ53	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008617.6\|UniProtKB=A0A337SF49	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845022474.1\|UniProtKB=A0A8I3S348	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000012170.4\|UniProtKB=F7CY98	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000042120.1\|UniProtKB=A0A6I8PP22	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010010928.1\|UniProtKB=F1NTZ8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014066.4\|UniProtKB=H9GKS9	Anolis carolinensis	LDO
ORYLA\|Ensembl=ENSORLG00000015420.2\|UniProtKB=H2MKT0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-090311-22\|UniProtKB=A0A8M3AW15	Danio rerio	O
DANRE\|Gene=hecw2b\|UniProtKB=A0A8M1RSA0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005202.1\|UniProtKB=W5MD07	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118425094\|UniProtKB=A0A9J7LWZ8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC764826\|UniProtKB=A0A7M7P5A8	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00009738\|UniProtKB=Q09291	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG09857\|UniProtKB=A8X9T9	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00093680\|UniProtKB=A0A2A6CHT9	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0261931\|UniProtKB=Q9W326	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP000797\|UniProtKB=A0A1S4GAL8	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC011808\|UniProtKB=D6WZM4	Tribolium castaneum	LDO
IXOSC\|EnsemblGenome=ISCW020326\|UniProtKB=B7PZW4	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g161803\|UniProtKB=A7RR93	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG22479\|UniProtKB=B3RRS5	Trichoplax adhaerens	O
YEAST\|SGD=S000000927\|UniProtKB=P39940	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADL055C\|UniProtKB=Q75AI2	Eremothecium gossypii	O
CANAL\|CGD=CAL0000178037\|UniProtKB=Q59Y21	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E18117g\|UniProtKB=Q6C5H0	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_01339\|UniProtKB=Q5BDP1	Emericella nidulans	O
ASPFU\|Gene_ORFName=AFUA_1G09500\|UniProtKB=Q4WTF3	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU03947\|UniProtKB=Q7RV01	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_03708\|UniProtKB=A7EEG8	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_05097\|UniProtKB=Q0UT17	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC1805.15c\|UniProtKB=Q9UTG2	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_01360\|UniProtKB=B6K0G7	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPBC16E9.11c\|UniProtKB=O14326	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04600\|UniProtKB=B6K793	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPAC11G7.02\|UniProtKB=Q92462	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03970\|UniProtKB=B6K5J7	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNH00220\|UniProtKB=Q5KC94	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00663\|UniProtKB=A0A0D1EDG8	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_21963\|UniProtKB=H6QSZ3	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_20868\|UniProtKB=F4PCI9	Batrachochytrium dendrobatidis	O
GIAIC\|Gene_ORFName=GL50803_0060667\|UniProtKB=A0A644F5R3	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_428690\|UniProtKB=A2FJ59	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_305420\|UniProtKB=A2ERB6	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00018801001\|UniProtKB=A0DNI8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013270001\|UniProtKB=A0D438	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018343001\|UniProtKB=A0DM58	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012736001\|UniProtKB=A0D2G1	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_37231\|UniProtKB=B8CBH5	Thalassiosira pseudonana	O
PHYRM\|Gene=H3HC66_PHYRM\|UniProtKB=H3HC66	Phytophthora ramorum	O
PHYRM\|Gene=H3GE55_PHYRM\|UniProtKB=H3GE55	Phytophthora ramorum	O
PHYRM\|Gene=H3GWW6_PHYRM\|UniProtKB=H3GWW6	Phytophthora ramorum	O
PHYRM\|Gene=H3GMB3_PHYRM\|UniProtKB=H3GMB3	Phytophthora ramorum	O
PHYRM\|Gene=H3GQD4_PHYRM\|UniProtKB=H3GQD4	Phytophthora ramorum	O
PHYRM\|Gene=H3GWW5_PHYRM\|UniProtKB=H3GWW5	Phytophthora ramorum	O
PHYRM\|Gene=H3GE54_PHYRM\|UniProtKB=H3GE54	Phytophthora ramorum	O
PHYRM\|Gene=H3HC58_PHYRM\|UniProtKB=H3HC58	Phytophthora ramorum	O
PHYRM\|Gene=H3GYP7_PHYRM\|UniProtKB=H3GYP7	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_12g548100v5\|UniProtKB=A0A2K3D6D9	Chlamydomonas reinhardtii	O