PANTHER Gene Information

Gene Symbol(s):

hsd11b2

Organism:

Danio rerio

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Gene Name:

11-beta-hydroxysteroid dehydrogenase type 2

Gene ID:

ZDB-GENE-030131-6030

Protein ID:

F1QLP1

Persistent Id:

PTN000671355

Alternate Ids:

DHI2_DANRE(UniProtKB-ID)	NM_212720(refSeq)
334098(GeneID)	Q6P0H9(AltAccession)
11-HSD type II(Synonym)	ZDB-GENE-030131-6030(ZFIN)
BC065613(EMBL)	hsd11b2(Symbol)
2203518814(GI)	AAH65613(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C (PTHR43313)
PANTHER Subfamily:	11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 (PTHR43313:SF2)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:	steroid metabolic process
PANTHER GO-slim Cellular Component:	intracellular membrane-bounded organelle
PANTHER protein class:	dehydrogenase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity, oxidoreductase activity, 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
GO BP Complete:	cortisol metabolic process, lipid metabolic process, multicellular organismal response to stress, regulation of response to stress, steroid metabolic process, glucocorticoid metabolic process
GO CC Complete:	intracellular membrane-bounded organelle, membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Drug ADME, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Metabolism, Glucocorticoid biosynthesis, Prednisone ADME

Orthologs

ID	Organism	Type
HUMAN\|HGNC=5209\|UniProtKB=P80365	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000008230.4\|UniProtKB=H2QBB5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012970.3\|UniProtKB=G3RB12	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008034.4\|UniProtKB=F7H597	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104720\|UniProtKB=P51661	Mus musculus	LDO
RAT\|RGD=2835\|UniProtKB=P50233	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000005685.4\|UniProtKB=F1N3U0	Bos taurus	O
BOVIN\|Gene=HSD11B2\|UniProtKB=O77667	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002777.4\|UniProtKB=Q8MKG1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014152.4\|UniProtKB=F7AU45	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000027537.4\|UniProtKB=A0A2I2UPP0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008256.1\|UniProtKB=A0A8I3N8C2	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000009417.3\|UniProtKB=F7EYS9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021624.1\|UniProtKB=A0A8V0ZL05	Gallus gallus	LDO
XENLA\|Gene=hsd11b2.L\|UniProtKB=A0A1L8GKH5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1012826\|UniProtKB=A0A803JH09	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000323.2\|UniProtKB=H2L3R6	Oryzias latipes	LDO
LEPOC\|Ensembl=ENSLOCG00000008179.1\|UniProtKB=W5MNI2	lepisosteus oculatus	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_291019\|UniProtKB=C3Y5N1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423322\|UniProtKB=A0A9J7N2P6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423325\|UniProtKB=A0A9J7N0Y7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC755047\|UniProtKB=A0A7M7G046	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC588241\|UniProtKB=A0A7M7P7U7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC581727\|UniProtKB=A0A7M7HKF1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC577402\|UniProtKB=A0A7M7RDM4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575923\|UniProtKB=A0A7M7P8E9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918616\|UniProtKB=A0A7M7NSX5	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0033679\|UniProtKB=Q7K3N4	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP011811\|UniProtKB=A0A1S4H8Q8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC000474\|UniProtKB=D6WA35	Tribolium castaneum	O
HELRO\|EnsemblGenome=HelroG185473\|UniProtKB=T1FMV1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG76379\|UniProtKB=T1G2J3	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g214506\|UniProtKB=A7SME4	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g123720\|UniProtKB=A7SME6	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g123713\|UniProtKB=A7SME5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g123699\|UniProtKB=A7SMF1	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g123682\|UniProtKB=A7SME8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g99318\|UniProtKB=A7RZX3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g129211\|UniProtKB=A7SRY0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g185226\|UniProtKB=A7S3H1	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g123722\|UniProtKB=A7SMF0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g127195\|UniProtKB=A7SQ85	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g177208\|UniProtKB=A7RFL9	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160897\|UniProtKB=A7RNE0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g83011\|UniProtKB=A7RIH3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g16279\|UniProtKB=A7T7M2	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG22801\|UniProtKB=B3RT60	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG21854\|UniProtKB=B3RPX7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG15925\|UniProtKB=B3RT65	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56068\|UniProtKB=B3RTW4	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG35982\|UniProtKB=B3RXQ2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG54855\|UniProtKB=B3RT66	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG54847\|UniProtKB=B3RT58	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG15365\|UniProtKB=B3RT67	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG15835\|UniProtKB=B3RT64	Trichoplax adhaerens	O
CANAL\|CGD=CAL0000193554\|UniProtKB=A0A1D8PT92	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F28545g\|UniProtKB=Q6C017	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00303\|UniProtKB=Q5BGM7	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_1G02710\|UniProtKB=Q4WKE9	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08354\|UniProtKB=Q7SGR1	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_05894\|UniProtKB=A7EKP7	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_04322\|UniProtKB=Q0UV92	Phaeosphaeria nodorum	O
SCLS1\|Gene_ORFName=SS1G_11353\|UniProtKB=A7F183	Sclerotinia sclerotiorum	O
PHANO\|Gene_ORFName=SNOG_01353\|UniProtKB=Q0V3R1	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_01839\|UniProtKB=Q0V2C5	Phaeosphaeria nodorum	O
PHANO\|Gene_ORFName=SNOG_15386\|UniProtKB=Q0TYX2	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC106.03\|UniProtKB=Q9URV8	Schizosaccharomyces pombe	O
USTMA\|EnsemblGenome=UMAG_10094\|UniProtKB=A0A0D1E7M7	Ustilago maydis	O
CHLRE\|EnsemblGenome=CHLRE_07g352450v5\|UniProtKB=A0A2K3DLE1	Chlamydomonas reinhardtii	O
CHLAA\|EnsemblGenome=Caur_0370\|UniProtKB=A9WDL4	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5086\|UniProtKB=P16544	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO7363\|UniProtKB=Q9KYM4	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv0765c\|UniProtKB=I6WZD9	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1544\|UniProtKB=Q10782	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3057c\|UniProtKB=I6YB11	Mycobacterium tuberculosis	O
DEIRA\|EnsemblGenome=DR_1938\|UniProtKB=Q9RT30	Deinococcus radiodurans	O
RHOBA\|EnsemblGenome=RB12296\|UniProtKB=Q7UIV9	Rhodopirellula baltica	O
BRADU\|Gene=Q89KC1_BRADU\|UniProtKB=Q89KC1	Bradyrhizobium diazoefficiens	O
PSEAE\|EnsemblGenome=PA3277\|UniProtKB=Q9HYW4	Pseudomonas aeruginosa	O