PANTHER Gene Information

Gene Symbol(s):

PYCR1

Organism:

Macaca mulatta

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Tree

Gene Name:

Pyrroline-5-carboxylate reductase

Gene ID:

ENSMMUG00000012895.4

Protein ID:

F6TMV9

Persistent Id:

PTN000182263

Alternate Ids:

F6TMV9_MACMU(UniProtKB-ID)	XP_014976041(refSeq)
387542020(GI)	ENSMMUT00000060884(Ensembl_TRS)
ENSMMUP00000033893(Ensembl_PRO)	715182(GeneID)
ENSMMUG00000012895(Ensembl)	F6TMV9(Synonym)
AFJ71637(EMBL-CDS)	JV636297(EMBL)
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PANTHER Classification

PANTHER Family:	PYRROLINE-5-CARBOXYLATE REDUCTASE (PTHR11645)
PANTHER Subfamily:	PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL (PTHR11645:SF6)
PANTHER GO-slim Molecular Function:	oxidoreductase activity
PANTHER GO-slim Biological Process:	L-amino acid biosynthetic process organic cyclic compound biosynthetic process heterocycle biosynthetic process proteinogenic amino acid biosynthetic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	reductase

Pathway Categories:

Proline biosynthesis

Pyrroline-5-carboxylate reductase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	pyrroline-5-carboxylate reductase activity, identical protein binding, oxidoreductase activity
GO BP Complete:	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of mitochondrial membrane potential, cellular response to oxidative stress, proline biosynthetic process, L-proline biosynthetic process
GO CC Complete:	mitochondrion

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9721\|UniProtKB=P32322	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000013977.3\|UniProtKB=G3RDM4	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=2384795\|UniProtKB=Q922W5	Mus musculus	LDO
RAT\|RGD=1307863\|UniProtKB=D3ZXI0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000055091.1\|UniProtKB=A0A3Q1LIA7	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000000042\|UniProtKB=Q58DT4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000034723.3\|UniProtKB=A0A287A0V6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008836.4\|UniProtKB=A0A3Q2HE24	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000044386.2\|UniProtKB=M3WH51	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008603.1\|UniProtKB=A0A8I3NBT0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003122.4\|UniProtKB=A0A5F8G2X3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000005270.3\|UniProtKB=A0A6I8NVG9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010029288.1\|UniProtKB=A0A1D5PKK0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010316.4\|UniProtKB=G1KK19	Anolis carolinensis	LDO
XENLA\|Gene=pycr1.L\|UniProtKB=Q6INR2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1016046\|UniProtKB=Q28C85	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007843.2\|UniProtKB=H2LUP8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-1675\|UniProtKB=Q6P971	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000027940.1\|UniProtKB=A0A3B3IJD6	Oryzias latipes	LDO
DANRE\|Gene=pycr1b\|UniProtKB=A0A8M9Q700	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012583.1\|UniProtKB=W5N4D5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000005415.3\|UniProtKB=F6Z9B3	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000003298.3\|UniProtKB=F6W1X7	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_212546\|UniProtKB=C3YE07	Branchiostoma floridae	O
BRAFL\|Gene=LOC118404265\|UniProtKB=A0A9J7K6Y3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC583871\|UniProtKB=A0A7M7RHE6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC583853\|UniProtKB=A0A7M7RFI2	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC115923412\|UniProtKB=A0A7M7NPY7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00018904\|UniProtKB=Q20848	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00028244\|UniProtKB=A8X1F4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00095953\|UniProtKB=A0A2A6CAY6	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00010924\|UniProtKB=Q21544	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG16221\|UniProtKB=A8XNV3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00106938\|UniProtKB=A0A2A6CFQ0	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0015781\|UniProtKB=Q9V3F8	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002308\|UniProtKB=Q7QBU0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC000534\|UniProtKB=D6W9S0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC000533\|UniProtKB=D6W9S1	Tribolium castaneum	O
DROME\|FlyBase=FBgn0038516\|UniProtKB=Q9VEJ3	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP005009\|UniProtKB=Q7PPH9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003549\|UniProtKB=D6WHI9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_304427\|UniProtKB=E9GLH5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_65532\|UniProtKB=E9HSB4	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW020302\|UniProtKB=B7Q351	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG186252\|UniProtKB=T1FNV4	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160797\|UniProtKB=A7RN43	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g235823\|UniProtKB=A7SQR3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG27568\|UniProtKB=B3S202	Trichoplax adhaerens	LDO
YEAST\|SGD=S000000825\|UniProtKB=P32263	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABR168W\|UniProtKB=Q75D55	Eremothecium gossypii	O
CANAL\|CGD=CAL0000177527\|UniProtKB=A0A1D8PKZ7	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B14399g\|UniProtKB=Q6CEN0	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_06025\|UniProtKB=Q5B0A5	Emericella nidulans	O
PHANO\|EnsemblGenome=SNOG_07577\|UniProtKB=Q0UKY7	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_09279\|UniProtKB=Q5AR01	Emericella nidulans	O
SCLS1\|Gene_ORFName=SS1G_10864\|UniProtKB=A7EZU7	Sclerotinia sclerotiorum	O
EMENI\|EnsemblGenome=ANIA_04355\|UniProtKB=Q5B525	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G02310\|UniProtKB=Q4WFG1	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_03681\|UniProtKB=A7EEE1	Sclerotinia sclerotiorum	O
NEUCR\|EnsemblGenome=NCU06471\|UniProtKB=Q12641	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_10564\|UniProtKB=A7EYZ8	Sclerotinia sclerotiorum	O
SCLS1\|Gene_ORFName=SS1G_09630\|UniProtKB=A7EWC1	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_13893\|UniProtKB=Q0U2X1	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAPYUG7.05\|UniProtKB=Q9P7Y7	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00120\|UniProtKB=B6JXI1	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNF00740\|UniProtKB=Q5KFS4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00547\|UniProtKB=A0A0D1D180	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_01617\|UniProtKB=E3JSA3	Puccinia graminis	O
DICDI\|dictyBase=DDB_G0269410\|UniProtKB=Q55E34	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_91270\|UniProtKB=F0ZA53	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0288671\|UniProtKB=Q54IL7	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_36148\|UniProtKB=F0ZQG6	Dictyostelium purpureum	O
TRIV3\|Gene_ORFName=TVAG_091200\|UniProtKB=A2F624	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_423640\|UniProtKB=A2DTK2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_063510\|UniProtKB=A2EU21	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1357900\|UniProtKB=Q8IDC6	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_23275\|UniProtKB=B8C4H2	Thalassiosira pseudonana	O
CHLRE\|EnsemblGenome=CHLRE_03g154550v5\|UniProtKB=A8J7M2	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00053p00048140\|UniProtKB=W1PAQ3	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_10G01620\|UniProtKB=A0A0K9Q3M8	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_8G01650\|UniProtKB=A0A0K9NJS0	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g18670\|UniProtKB=A0A804L9B3	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_002357mg\|UniProtKB=K3XKD4	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G424300\|UniProtKB=C5XHU2	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb141220\|UniProtKB=Q4TZJ2	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0948400\|UniProtKB=Q0JG21	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g60730v3\|UniProtKB=I1HV71	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0319810\|UniProtKB=F2E7Q2	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3B02G538100\|UniProtKB=Q5EI64	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G483400\|UniProtKB=A0A3B6H2J0	Triticum aestivum	O
NELNU\|Gene=LOC104608871\|UniProtKB=A0A1U8BAX0	Nelumbo nucifera	O
SPIOL\|Gene=LOC110778505\|UniProtKB=A0A9R0HXA9	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0404011\|UniProtKB=A0A251TXY2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400207390\|UniProtKB=A0A9R1VZX6	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a011565mg\|UniProtKB=A0A022Q2N8	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_12092\|UniProtKB=A0A2G2ZNT4	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400010441\|UniProtKB=M1AP43	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g068640.3\|UniProtKB=A0A3Q7FME1	Solanum lycopersicum	O
TOBAC\|Gene=LOC107788377\|UniProtKB=A0A1S3ZME2	Nicotiana tabacum	O
TOBAC\|Gene=LOC107814177\|UniProtKB=A0A1S4C1H9	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g01672\|UniProtKB=D7TIL1	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K01625\|UniProtKB=A0A059A2B0	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00009027001\|UniProtKB=A0A078G1V3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00001624001\|UniProtKB=A0A078F884	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_C09P62360.1\|UniProtKB=A0A078F9Z9	Brassica napus	O
BRACM\|EnsemblGenome=Bra006270\|UniProtKB=M4CPY1	Brassica campestris	O
BRACM\|EnsemblGenome=Bra008735\|UniProtKB=A0A3P6CM01	Brassica campestris	O
ARATH\|TAIR=locus=2185435\|UniProtKB=P54904	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107953821\|UniProtKB=A0A1U8P0I8	Gossypium hirsutum	O
GOSHI\|Gene=LOC107900495\|UniProtKB=A0A1U8IU09	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_024404\|UniProtKB=A0A061EVD2	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g023866mg\|UniProtKB=A0A067EFZ1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_006G042600v3\|UniProtKB=B9H956	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_1107270\|UniProtKB=B9SZS7	Ricinus communis	O
SOYBN\|Gene=P5CR_SOYBN\|UniProtKB=P17817	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_19G131500\|UniProtKB=A0A0R0ELE0	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_03G129100\|UniProtKB=K7KEQ2	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g090160\|UniProtKB=G7KRM5	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr03_05520\|UniProtKB=A0A2I4ECU5	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G354630\|UniProtKB=A0A0A0KYH5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_7G045400\|UniProtKB=M5W9Z2	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_7G045500\|UniProtKB=M5W2Z7	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_235312\|UniProtKB=D8SW34	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_183368\|UniProtKB=D8SWL5	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_15650\|UniProtKB=A0A2K1JZ49	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0029s0092\|UniProtKB=A0A2R6X8Y5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000650250\|UniProtKB=A0A1Y1HSV0	Klebsormidium nitens	O
KORCO\|EnsemblGenome=Kcr_0735\|UniProtKB=B1L4V5	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0495\|UniProtKB=Q97ZT3	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1917\|UniProtKB=Q8ZW86	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_4102\|UniProtKB=Q9HH99	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0784\|UniProtKB=Q58194	Methanocaldococcus jannaschii	O
STRCO\|Gene_OrderedLocusName=SCO3337\|UniProtKB=Q9X8G1	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv0500\|UniProtKB=P9WHU7	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO3182\|UniProtKB=A5I6R1	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0834\|UniProtKB=Q8DQ59	Streptococcus pneumoniae	O
LISMO\|Gene=Q8Y7A2_LISMO\|UniProtKB=Q8Y7A2	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_25600\|UniProtKB=P39696	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4325\|UniProtKB=Q818D6	Bacillus cereus	O
BACSU\|EnsemblGenome=BSU_12910\|UniProtKB=Q00777	Bacillus subtilis	O
STAA8\|EnsemblGenome=SAOUHSC_01597\|UniProtKB=Q2FY68	Staphylococcus aureus	O
LISMO\|Gene=proC\|UniProtKB=Q8Y9X2	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_18480\|UniProtKB=P0CI77	Bacillus subtilis	O
BACSU\|EnsemblGenome=BSU_23800\|UniProtKB=P54552	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_0218\|UniProtKB=Q81IX6	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_4134\|UniProtKB=Q818V7	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_3109\|UniProtKB=Q7BYC2	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_2977\|UniProtKB=Q81C08	Bacillus cereus	O
THEMA\|EnsemblGenome=TM_0578\|UniProtKB=Q9WZ47	Thermotoga maritima	O
DEIRA\|EnsemblGenome=DR_1522\|UniProtKB=Q9RU71	Deinococcus radiodurans	O
GLOVI\|Gene=proC\|UniProtKB=Q7NMR1	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA18679\|UniProtKB=P74572	Synechocystis	O
LEPIN\|EnsemblGenome=LA_1481\|UniProtKB=Q8F631	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_3757\|UniProtKB=Q8A1A9	Bacteroides thetaiotaomicron	O
BACTN\|EnsemblGenome=BT_1902\|UniProtKB=Q8A6I2	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB3891\|UniProtKB=Q7UTG7	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_166\|UniProtKB=O66553	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A1799\|UniProtKB=B5YHK4	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_1304\|UniProtKB=B8E0D3	Dictyoglomus turgidum	O
HELPY\|EnsemblGenome=HP_1158\|UniProtKB=O25773	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB0055\|UniProtKB=Q9K1N1	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU2541\|UniProtKB=Q74A50	Geobacter sulfurreducens	O
BRADU\|Gene=Q89SX1_BRADU\|UniProtKB=Q89SX1	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=proC\|UniProtKB=Q89DI5	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_2090\|UniProtKB=Q83A21	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0307\|UniProtKB=P43869	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_3354\|UniProtKB=Q8EBZ1	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0460\|UniProtKB=Q9KUQ5	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC2757\|UniProtKB=Q8P757	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA0393\|UniProtKB=P22008	Pseudomonas aeruginosa	O
YERPE\|Gene_OrderedLocusName=YPO0942\|UniProtKB=A0A5P8YCL9	Yersinia pestis	O