PANTHER Gene Information

Gene Symbol(s):

METTL3

Organism:

Pan troglodytes

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Gene Name:

Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

Gene ID:

ENSPTRG00000006127.4

Protein ID:

G2HF97

Persistent Id:

PTN000302841

Alternate Ids:

452765(GeneID)	GABF01007355(EMBL)
ENSPTRP00000010396(Ensembl_PRO)	JAA42983(EMBL-CDS)
G2HF97(Synonym)	ENSPTRT00000011237(Ensembl_TRS)
350537701(GI)	ENSPTRG00000006127(Ensembl)
G2HF97_PANTR(UniProtKB-ID)	NP_001233484(refSeq)
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PANTHER Classification

PANTHER Family:	N6-ADENOSINE-METHYLTRANSFERASE (PTHR12829)
PANTHER Subfamily:	N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT (PTHR12829:SF7)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	RNA methyltransferase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	RNA methyltransferase activity, RNA binding, mRNA m(6)A methyltransferase activity, protein heterodimerization activity, S-adenosyl-L-methionine binding, mRNA binding, methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity, catalytic activity, acting on a nucleic acid
GO BP Complete:	RNA methylation, regulation of macromolecule metabolic process, positive regulation of translation, primary miRNA processing, cellular response to UV, negative regulation of type I interferon-mediated signaling pathway, positive regulation of cap-independent translational initiation, dosage compensation by inactivation of X chromosome, DNA damage response, mRNA splicing, via spliceosome, mRNA modification, methylation
GO CC Complete:	nucleus, nuclear body, nuclear speck, RNA N6-methyladenosine methyltransferase complex, cytosol, Golgi apparatus, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=17563\|UniProtKB=Q86U44	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000005954.3\|UniProtKB=G3QT25	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000062638.1\|UniProtKB=G7MWT2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1927165\|UniProtKB=Q8C3P7	Mus musculus	LDO
RAT\|RGD=1311750\|UniProtKB=F7FFC6	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000015148.5\|UniProtKB=F1MX80	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000024445.4\|UniProtKB=F1S8J8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000013168.4\|UniProtKB=A0A9L0RZ65	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013861.6\|UniProtKB=M3WJL7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026804.1\|UniProtKB=A0A8I3Q0U5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000006085.4\|UniProtKB=F7FEI2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044138.1\|UniProtKB=A0A6I8NA09	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003470.1\|UniProtKB=A0A8V0XKP3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002851.4\|UniProtKB=H9G6T9	Anolis carolinensis	LDO
XENLA\|Gene=mettl3.L\|UniProtKB=Q6NUC3	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-922807\|UniProtKB=Q28H22	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007194.2\|UniProtKB=H2LSG5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-9498\|UniProtKB=F1R777	Danio rerio	LDO
BRAFL\|Gene=LOC118417847\|UniProtKB=A0A9J7LC50	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC589354\|UniProtKB=A0A7M7N4S3	Strongylocentrotus purpuratus	LDO
DROME\|FlyBase=FBgn0039139\|UniProtKB=Q9VCE6	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002895\|UniProtKB=Q7QD05	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009294\|UniProtKB=D6WRZ1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_305196\|UniProtKB=E9HVP4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_66395\|UniProtKB=E9HVP9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_192406\|UniProtKB=E9FZ30	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW004856\|UniProtKB=B7PGM5	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG79167\|UniProtKB=T1G3L1	helobdella robusta	LDO
YEAST\|SGD=S000003160\|UniProtKB=P41833	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AFR173W\|UniProtKB=Q753Z9	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000194048\|UniProtKB=Q5ALV0	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_B03498g\|UniProtKB=Q6CFV0	Yarrowia lipolytica	LDO
CRYNJ\|EnsemblGenome=CNE03860\|UniProtKB=Q5KGE9	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02989\|UniProtKB=A0A0D1DZK7	Ustilago maydis	LDO
TRIV3\|Gene_ORFName=TVAG_389630\|UniProtKB=A2E165	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_062450\|UniProtKB=A2DLK7	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_136190\|UniProtKB=A2DJA1	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_002370\|UniProtKB=A2G7D5	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00015836001\|UniProtKB=Q3SE44	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027862001\|UniProtKB=Q3SE45	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000069001\|UniProtKB=A0BAR7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003428001\|UniProtKB=Q3SE39	Paramecium tetraurelia	LDO
CHLRE\|EnsemblGenome=CHLRE_06g288100v5\|UniProtKB=A0A2K3DQ86	Chlamydomonas reinhardtii	LDO
PARTE\|EnsemblGenome=GSPATT00005554001\|UniProtKB=A0BUU1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024232001\|UniProtKB=A0E887	Paramecium tetraurelia	O
CHLRE\|EnsemblGenome=CHLRE_10g452300v5\|UniProtKB=A0A2K3DB89	Chlamydomonas reinhardtii	O
PLAF7\|EnsemblGenome=PF3D7_0729500\|UniProtKB=Q8I6Z2	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00017263001\|UniProtKB=Q3SE37	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019450001\|UniProtKB=A0DRR5	Paramecium tetraurelia	O
CHLRE\|EnsemblGenome=CHLRE_06g295600v5\|UniProtKB=A0A2K3DQK0	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00041p00134980\|UniProtKB=W1PZ08	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_246G00180\|UniProtKB=A0A0K9PH02	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g03270\|UniProtKB=A0A804L3R4	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma08_g11580\|UniProtKB=A0A804K5I6	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_016493mg\|UniProtKB=K3YQF0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G285000\|UniProtKB=C5Y1A7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb250310\|UniProtKB=B6SVX1	Zea mays	O
ORYSJ\|EnsemblGenome=Os02g0672600\|UniProtKB=Q6EU10	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g51437v3\|UniProtKB=A0A0Q3FME1	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0603200\|UniProtKB=A0A8I6Z2K6	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6A02G254900\|UniProtKB=A0A3B6NSQ7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G270600\|UniProtKB=A0A3B6PPP5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G236200\|UniProtKB=A0A3B6QIH5	Triticum aestivum	O
NELNU\|Gene=LOC104594082\|UniProtKB=A0A1U7ZU86	Nelumbo nucifera	O
SPIOL\|Gene=LOC110796381\|UniProtKB=A0A9R0IZ85	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr17g0780261\|UniProtKB=A0A251RLB2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C300106410\|UniProtKB=A0A9R1W422	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a002262mg\|UniProtKB=A0A022PZN4	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_23009\|UniProtKB=A0A2G2YR97	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_21568\|UniProtKB=A0A1U8DUK0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400004314\|UniProtKB=M0ZYX7	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc08g066730.3\|UniProtKB=A0A3Q7HNT5	Solanum lycopersicum	O
TOBAC\|Gene=LOC107788400\|UniProtKB=A0A1S3ZMH3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107790746\|UniProtKB=A0A1S3ZV37	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi02g00210\|UniProtKB=F6HU66	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_D01689\|UniProtKB=A0A059CGE6	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00010860001\|UniProtKB=A0A078IVV7	Brassica napus	O
BRACM\|EnsemblGenome=Bra035280\|UniProtKB=M4F2I1	Brassica campestris	O
ARATH\|TAIR=locus=2132731\|UniProtKB=O82486	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107947151\|UniProtKB=A0A1U8NGX7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107947165\|UniProtKB=A0A1U8NDX6	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_015668\|UniProtKB=A0A061GA47	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g005272mg\|UniProtKB=A0A067GAU4	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G085200v3\|UniProtKB=A0A2K2BUI9	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_02G004000\|UniProtKB=A0A2C9W9L5	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1312970\|UniProtKB=B9RYS4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_16G033100\|UniProtKB=I1MKT1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_07G067100\|UniProtKB=I1KI62	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g099870\|UniProtKB=G7IUG5	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_8g104280\|UniProtKB=G7L9Q3	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr09_09420\|UniProtKB=A0A2I4EY81	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G002950\|UniProtKB=A0A0A0L694	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G128200\|UniProtKB=A0A251P7L6	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_123364\|UniProtKB=D8SRV5	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c1_32590\|UniProtKB=A0A2K1LAL9	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0036s0127\|UniProtKB=A0A2R6X4X1	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000620090\|UniProtKB=A0A1Y1HQ67	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_1165\|UniProtKB=A9A5Q6	Nitrosopumilus maritimus	LDO