PANTHER Gene Information   
Gene Symbol(s): egl-8
Organism: Caenorhabditis elegans
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Gene Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
Gene ID: WBGene00001177
Protein ID: G5EBH0
Persistent Id: PTN000036922
Alternate Ids:
CCD61782(EMBL-CDS) AF179426(EMBL)
351065799(GI) WBGene00001177(Ensembl)
WBGene00001177(WormBase) 178537(GeneID)
PLCB(Synonym) PLCB_CAEEL(UniProtKB-ID)
B0348.4b(WormBase_TRS) Q95X30(AltAccession)
3.1.4.11 {ECO:0000250|UniProtKB:Q9QW07}(EC) CE36909(WormBase_PRO)
egl-8{ECO:0000312|EMBL:CCD61783.1,ECO:0000312|WormBase:B0348.4b}(Symbol)
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PANTHER Classification
PANTHER Family: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN (PTHR10336)
PANTHER Subfamily: 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 (PTHR10336:SF36)  
PANTHER GO-slim Molecular Function: phospholipase C activity
PANTHER GO-slim Biological Process: release of sequestered calcium ion into cytosol
intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class: phospholipase
Pathway Categories: Thyrotropin-releasing hormone receptor signaling pathway
   Phospholipase C
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
   Phospholipase C
Wnt signaling pathway
   Phospholipase C
Oxytocin receptor mediated signaling pathway
   Phospholipase C beta
Alpha adrenergic receptor signaling pathway
   Phospholipase C
EGF receptor signaling pathway
   phospholipase c gamma
Endothelin signaling pathway
   Phospholipase C beta
5HT2 type receptor mediated signaling pathway
   Phospholipase C
Inflammation mediated by chemokine and cytokine signaling pathway
   Phospholipase C
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Phospholipase C-beta
Metabotropic glutamate receptor group I pathway
   Phospholipase C
Histamine H1 receptor mediated signaling pathway
   Phospholipase C

GO MF Complete: phosphatidylinositol phospholipase C activity, metal ion binding, calcium ion binding, phosphoric diester hydrolase activity, hydrolase activity
GO BP Complete: positive regulation of acetylcholine secretion, neurotransmission, regulation of locomotion, signal transduction, G protein-coupled dopamine receptor signaling pathway, phosphatidylinositol metabolic process, positive regulation of locomotion, chemotaxis, regulation of nematode pharyngeal pumping, positive regulation of axon regeneration, regulation of egg-laying behavior, thermotaxis, phosphatidylinositol-mediated signaling, lipid metabolic process, lipid catabolic process, protein localization to synapse, release of sequestered calcium ion into cytosol, intracellular signal transduction
GO CC Complete: adherens junction, anchoring junction, synapse, perikaryon, cell projection, plasma membrane, axon
Reactome Pathways: Signaling by GPCR, Synthesis of IP3 and IP4 in the cytosol, Inositol phosphate metabolism, Signal Transduction, PLC beta mediated events, GPCR downstream signalling, G alpha (q) signalling events, G-protein mediated events, G alpha (i) signalling events, Metabolism, Opioid Signalling