PANTHER Gene Information   
Gene Symbol(s): let-92
Organism: Caenorhabditis elegans
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Gene Name: Serine_threonine-protein phosphatase 2A catalytic subunit
Gene ID: WBGene00002363
Protein ID: G5EGK8
Persistent Id: PTN000185750
Alternate Ids:
NP_502247(refSeq) 3.1.3.16 {ECO:0000255|RuleBase:RU004273}(EC)
1100163565(GI) PP2A_CAEEL(UniProtKB-ID)
CAB01174(EMBL-CDS) WBGene00002363(Ensembl)
F38H4.9(Ensembl_TRS) BX284604(EMBL)
PP2A(Synonym) let-92{ECO:0000312|WormBase:F38H4.9}(Symbol)
F38H4(WormBase_TRS) F38H4.9(Ensembl_PRO)
WBGene00002363(WormBase) CE10074(WormBase_PRO)
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PANTHER Classification
PANTHER Family: SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED (PTHR45619)
PANTHER Subfamily: SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM (PTHR45619:SF12)  
PANTHER GO-slim Molecular Function: protein serine/threonine phosphatase activity
PANTHER GO-slim Biological Process: mitotic cell cycle
PANTHER GO-slim Cellular Component: cytosol
PANTHER protein class: protein phosphatase
Pathway Categories: EGF receptor signaling pathway
   protein phosphatase 2A
p53 pathway feedback loops 2
   Protein phosphatase 2 catalytic subunit
p53 pathway
   Protein phosphatase 2A
Wnt signaling pathway
   Protein phosphatase 2A
p53 pathway by glucose deprivation
   Protein phosphatase 2 catalytic subunit
FGF signaling pathway
   protein phosphatase 2A
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein binding, DEAD/H-box RNA helicase binding, metal ion binding, hydrolase activity, myosin phosphatase activity
GO BP Complete: mitotic nuclear membrane reassembly, centrosome separation, mitotic spindle organization, mitotic centrosome separation, pronuclear envelope synthesis, meiotic spindle disassembly, mitotic cell cycle
GO CC Complete: centrosome, cytoskeleton, cytoplasm, axonal growth cone, cytosol, neuronal cell body, protein phosphatase type 2A complex, perikaryon, cell projection, axon
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Nuclear Envelope (NE) Reassembly, PKR-mediated signaling, Signaling by NTRKs, Intracellular signaling by second messengers, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Costimulation by the CD28 family, Mitotic G2-G2/M phases, Adaptive Immune System, MAPK targets/ Nuclear events mediated by MAP kinases, TRIF(TICAM1)-mediated TLR4 signaling , ERK/MAPK targets, Beta-catenin phosphorylation cascade, Interferon Signaling, Signaling by WNT, Metabolism of RNA, Signaling by Receptor Tyrosine Kinases, RAF activation, Negative regulation of MAPK pathway, RAF/MAP kinase cascade, ERKs are inactivated, PIP3 activates AKT signaling, Toll Like Receptor 4 (TLR4) Cascade, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, MAP kinase activation, Cell Cycle, Mitotic, Toll Like Receptor 2 (TLR2) Cascade, Nonsense-Mediated Decay (NMD), G1 Phase, Signaling by Interleukins, Cyclin D associated events in G1, G2/M Transition, Mitotic G1 phase and G1/S transition, Cyclin A/B1/B2 associated events during G2/M transition, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Toll Like Receptor 3 (TLR3) Cascade, MAPK1/MAPK3 signaling, MyD88 dependent cascade initiated on endosome, MyD88 cascade initiated on plasma membrane, Cell Cycle, Signal Transduction, Innate Immune System, Mitotic Metaphase and Anaphase, CTLA4 inhibitory signaling, Interleukin-17 signaling, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Toll Like Receptor 5 (TLR5) Cascade, Signaling by NTRK1 (TRKA), MAPK family signaling cascades, Toll-like Receptor Cascades, Toll Like Receptor 9 (TLR9) Cascade, Mitotic Anaphase, M Phase, Degradation of beta-catenin by the destruction complex, Toll Like Receptor 7/8 (TLR7/8) Cascade, Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, MyD88-independent TLR4 cascade , Nuclear Events (kinase and transcription factor activation), Negative regulation of the PI3K/AKT network, Initiation of Nuclear Envelope (NE) Reformation, Toll Like Receptor TLR6:TLR2 Cascade, Toll Like Receptor 10 (TLR10) Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Orthologs