PANTHER Gene Information

Gene Symbol(s):

rap-2

Organism:

Caenorhabditis elegans

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Gene Name:

small monomeric GTPase

Gene ID:

WBGene00004308

Protein ID:

O17599

Persistent Id:

PTN000631720

Alternate Ids:

WBGene00004308(Ensembl)	CAB02777(EMBL-CDS)
NP_506707(refSeq)	37619841(GI)
BX284605(EMBL)	O17599_CAEEL(UniProtKB-ID)
C25D7(WormBase_TRS)	O17599(Synonym)
WBGene00004308(WormBase)	CE35831(WormBase_PRO)
180011(GeneID)
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PANTHER Classification

PANTHER Family:	RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY (PTHR24070)
PANTHER Subfamily:	SMALL MONOMERIC GTPASE (PTHR24070:SF406)
PANTHER GO-slim Molecular Function:	nucleotide binding anion binding carbohydrate derivative binding GTPase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	small GTPase

Pathway Categories:

Integrin signalling pathway

Ras associated protein 1

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	GTP binding, GTPase activity, G protein activity, GDP binding
GO BP Complete:	collagen and cuticulin-based cuticle development, signal transduction, epidermis development, Rap protein signal transduction, negative regulation of cell migration
GO CC Complete:	cytoplasmic vesicle membrane, bounding membrane of organelle, membrane, recycling endosome membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Neutrophil degranulation, Innate Immune System, Immune System

Orthologs

ID	Organism	Type
BRAFL\|Gene=LOC118412688\|UniProtKB=A0A9J7ML08	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC581717\|UniProtKB=A0A7M7PU47	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC762467\|UniProtKB=A0A7M7N0Y1	Strongylocentrotus purpuratus	O
MOUSE\|MGI=MGI=2685112\|UniProtKB=A6H634	Mus musculus	O
RAT\|RGD=1565168\|UniProtKB=A0A8I6GGJ6	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000047319.2\|UniProtKB=G3N0N8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000036820.3\|UniProtKB=A0A8W4FN28	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000037072.2\|UniProtKB=A0A3Q2GVU5	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000047159.1\|UniProtKB=A0A5F5Y549	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845017991.1\|UniProtKB=A0A8I3P5Y4	Canis lupus familiaris	O
HUMAN\|HGNC=21165\|UniProtKB=Q9Y3L5	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000045178.1\|UniProtKB=K7CR35	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000021967.2\|UniProtKB=G3RND5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000048745.2\|UniProtKB=F6VPD5	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1919315\|UniProtKB=Q8BU31	Mus musculus	LDO
RAT\|RGD=1588562\|UniProtKB=D3ZK56	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000004131\|UniProtKB=Q08DI5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000026301.5\|UniProtKB=I3LH60	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000025399.4\|UniProtKB=M3X279	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845031086.1\|UniProtKB=A0A8I3QCP6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000015308.4\|UniProtKB=F6XZ48	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011699.3\|UniProtKB=F7A1D4	Ornithorhynchus anatinus	LDO
XENLA\|Gene=rap2c.S\|UniProtKB=Q7ZY32	Xenopus laevis	O
XENLA\|Gene=rap2c.L\|UniProtKB=Q498G9	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-489027\|UniProtKB=F7EF04	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000002178.2\|UniProtKB=H2LA05	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-041024-1\|UniProtKB=Q5XJT7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015061.1\|UniProtKB=W5ND26	lepisosteus oculatus	LDO
HUMAN\|HGNC=9862\|UniProtKB=P61225	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000052751.1\|UniProtKB=H2QNL9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000041894.1\|UniProtKB=A0A2I2Z1X2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000015779.3\|UniProtKB=F7AWM6	Macaca mulatta	O
MOUSE\|MGI=MGI=1921262\|UniProtKB=P61226	Mus musculus	O
RAT\|RGD=620591\|UniProtKB=P61227	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000055257.1\|UniProtKB=A4IFU2	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000038366\|UniProtKB=Q06AU2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000024986.3\|UniProtKB=A0A3Q2I008	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000005952.4\|UniProtKB=M3W509	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845020015.1\|UniProtKB=A0A8I3PII6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000024599.1\|UniProtKB=F7DGX0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000045350.1\|UniProtKB=A0A6I8N9U8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010001535.1\|UniProtKB=A0A8V0XBX5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000011260.1\|UniProtKB=G1KL05	Anolis carolinensis	O
XENLA\|Gene=rap2b.S\|UniProtKB=Q6NS13	Xenopus laevis	O
XENLA\|Gene=rap2b.L\|UniProtKB=A0A1L8GAX7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-493696\|UniProtKB=Q28G68	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000005875.2\|UniProtKB=H2LMW8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-2818\|UniProtKB=Q7SY59	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000017378.1\|UniProtKB=W5NLH4	lepisosteus oculatus	O
HUMAN\|HGNC=9861\|UniProtKB=P10114	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000005983.6\|UniProtKB=H2Q7Q7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000039196.1\|UniProtKB=A0A2I2YVG8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000062318.1\|UniProtKB=F7GCR4	Macaca mulatta	O
MOUSE\|MGI=MGI=97855\|UniProtKB=Q80ZJ1	Mus musculus	O
RAT\|RGD=620590\|UniProtKB=A0A0G2JTW1	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000020412.3\|UniProtKB=E1BNQ3	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000039812.3\|UniProtKB=A0A286ZUT3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000033905.2\|UniProtKB=A0A9L0SXX7	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000051427.1\|UniProtKB=A0A9L0TCN0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000044348.2\|UniProtKB=A0A2I2UK19	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845019567.1\|UniProtKB=A0A8I3NYQ1	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000043319.1\|UniProtKB=A0A5F8G1X1	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000047686.1\|UniProtKB=A0A5F8G780	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000042125.1\|UniProtKB=A0A6I8PC07	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017228.1\|UniProtKB=A0A8V0Z084	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010005237.1\|UniProtKB=E1BQI2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000041592.1\|UniProtKB=A0A803TZK0	Anolis carolinensis	O
XENLA\|Gene=LOC100505442\|UniProtKB=Q6NRU1	Xenopus laevis	O
XENLA\|Gene=rap2a.S\|UniProtKB=Q7ZX67	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-479951\|UniProtKB=Q28GA4	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000005426.2\|UniProtKB=H2LLC1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000023558.1\|UniProtKB=A0A3B3I3L6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-090312-116\|UniProtKB=B8JIV0	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-121018-1\|UniProtKB=E7F144	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003615.1\|UniProtKB=W5M7C9	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000016915.2\|UniProtKB=F6Q349	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000001232.3\|UniProtKB=F6SBR0	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417903\|UniProtKB=A0A9J7LB66	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426848\|UniProtKB=A0A9J7N403	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426813\|UniProtKB=A0A9J7M0R3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC753090\|UniProtKB=A0A7M7HKA0	Strongylocentrotus purpuratus	LDO
CAEBR\|WormBase=WBGene00032680\|UniProtKB=A8XDJ3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00096817\|UniProtKB=A0A2A6CB88	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00102177\|UniProtKB=A0A2A6CSY2	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0283666\|UniProtKB=O96692	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004769\|UniProtKB=Q7PMT0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC001713\|UniProtKB=D6W8A5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_318262\|UniProtKB=E9GIA3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG156884\|UniProtKB=T1EM26	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG154062\|UniProtKB=T1ELD6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g16994\|UniProtKB=A7SI57	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g204358\|UniProtKB=A7RZ86	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g83753\|UniProtKB=A7RJN8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g119290\|UniProtKB=A7SI58	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g69635\|UniProtKB=A8DW02	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g195002\|UniProtKB=A7SZN4	Nematostella vectensis	LDO
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g139295\|UniProtKB=A7SZM4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g72442\|UniProtKB=A7S8C2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g151852\|UniProtKB=A7T9Z6	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG56973\|UniProtKB=B3RX28	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG49712\|UniProtKB=B3RLY8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_2929\|UniProtKB=A9UPR8	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_37080\|UniProtKB=A9UZG5	Monosiga brevicollis	O
YEAST\|SGD=S000003384\|UniProtKB=P13856	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR066C\|UniProtKB=Q75C51	Eremothecium gossypii	O
EREGS\|EnsemblGenome=AGOS_AFR464W\|UniProtKB=Q752V9	Eremothecium gossypii	O
CANAL\|CGD=CAL0000199219\|UniProtKB=A0A1D8PS50	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F23177g\|UniProtKB=Q6C0N5	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_04685\|UniProtKB=C8VAZ3	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G08950\|UniProtKB=Q4WUM2	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU02167\|UniProtKB=Q7SEQ0	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_03294\|UniProtKB=A7EDA4	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_09547\|UniProtKB=Q0UFB7	Phaeosphaeria nodorum	O
USTMA\|EnsemblGenome=UMAG_11909\|UniProtKB=A0A0D1C7L9	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_12740\|UniProtKB=E3KRS4	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_23334\|UniProtKB=F4NYQ1	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_004860\|UniProtKB=C4M081	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_058090\|UniProtKB=C4M8B0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_109840\|UniProtKB=C4M3K3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_049030\|UniProtKB=B1N4V4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0272857\|UniProtKB=Q86L51	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_26434\|UniProtKB=F0Z8S2	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0270340\|UniProtKB=Q55BW0	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_74092\|UniProtKB=F0Z6W4	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0291237\|UniProtKB=P18613	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_59134\|UniProtKB=F1A4I5	Dictyostelium purpureum	O
TRYB2\|Gene_ORFName=Tb11.02.3850\|UniProtKB=Q385G5	Trypanosoma brucei	O
TRIV3\|Gene_ORFName=TVAG_121390\|UniProtKB=A2G0V9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_202040\|UniProtKB=A2DWM5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_404090\|UniProtKB=A2EGF8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_580280\|UniProtKB=A2G856	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_533910\|UniProtKB=A2G1N8	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00027953001\|UniProtKB=A0BEF3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014016001\|UniProtKB=A0D7N2	Paramecium tetraurelia	O
PHYRM\|Gene=H3GA69_PHYRM\|UniProtKB=H3GA69	Phytophthora ramorum	O