PANTHER Gene Information

Gene Symbol(s):

top-1

Organism:

Caenorhabditis elegans

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Gene Name:

DNA topoisomerase 1

Gene ID:

WBGene00006595

Protein ID:

O17966

Persistent Id:

PTN000033296

Alternate Ids:

CAB07639(EMBL-CDS)	1934847(GI)
topoI(Synonym)	top-1(Symbol)
266847(GeneID)	X96762(EMBL)
NP_001021578(refSeq)	Q27529(AltAccession)
WBGene00006595(WormBase)	5.6.2.1 {ECO:0000255\|PROSITE-ProRule:PRU10130}(EC)
M01E5.5a(WormBase_TRS)	CE12282(WormBase_PRO)
TOP1_CAEEL(UniProtKB-ID)	WBGene00006595(Ensembl)
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PANTHER Classification

PANTHER Family:	DNA TOPOISOMERASE I (PTHR10290)
PANTHER Subfamily:	DNA TOPOISOMERASE 1 (PTHR10290:SF3)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	DNA topoisomerase

Pathway Categories:

DNA replication

DNA Topoisomerase

DNA replication

Topoisomerase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	DNA binding, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO BP Complete:	DNA replication, chromosome segregation, DNA topological change
GO CC Complete:	nucleus, spindle pole centrosome, chromosome, nucleolus

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

SUMOylation of DNA replication proteins, SUMO E3 ligases SUMOylate target proteins, Post-translational protein modification, SUMOylation, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=29787\|UniProtKB=Q969P6	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000020653.6\|UniProtKB=H2RD14	Pan troglodytes	O
PANTR\|Gene=TOP1MT\|UniProtKB=A9Q1D5	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000009313.3\|UniProtKB=G3R1M7	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022933.4\|UniProtKB=F6U741	Macaca mulatta	O
MOUSE\|MGI=MGI=1920210\|UniProtKB=Q8R4U6	Mus musculus	O
RAT\|RGD=1303177\|UniProtKB=Q6IM78	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000053896.1\|UniProtKB=A0A3Q1LRV4	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000006958.5\|UniProtKB=F1SEV4	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013129.4\|UniProtKB=F7B8X2	Equus caballus	O
MONDO\|Ensembl=ENSMODG00000029734.2\|UniProtKB=K7E194	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000009984.3\|UniProtKB=A0A6I8P6D8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010008081.1\|UniProtKB=A0A8V0Y408	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000001329.4\|UniProtKB=H9G579	Anolis carolinensis	O
XENLA\|Gene=LOC108719456\|UniProtKB=A0A1L8G0C9	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-488998\|UniProtKB=A0A803KJ00	Xenopus tropicalis	O
XENTR\|Ensembl=ENSXETG00000046294\|UniProtKB=A0A6I8QI59	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-040624-2\|UniProtKB=Q6T721	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008408.1\|UniProtKB=W5MPB0	lepisosteus oculatus	O
XENLA\|Gene=top1.2.S\|UniProtKB=A0A1L8GF75	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5814502\|UniProtKB=F6YVL0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000015781.2\|UniProtKB=A0A3B3I355	Oryzias latipes	LDO
DANRE\|Gene=zgc=173742\|UniProtKB=A0A8M2BH93	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002229.1\|UniProtKB=W5M2K4	lepisosteus oculatus	LDO
HUMAN\|HGNC=11986\|UniProtKB=P11387	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000013498.7\|UniProtKB=H2QKC9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000009000.3\|UniProtKB=G3R0W2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000011112.4\|UniProtKB=H9FZ51	Macaca mulatta	O
MOUSE\|MGI=MGI=98788\|UniProtKB=Q04750	Mus musculus	O
RAT\|RGD=621246\|UniProtKB=Q9WUL0	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000007960.4\|UniProtKB=F1MN93	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000051926.1\|UniProtKB=A0A8W4F7R9	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000007355.5\|UniProtKB=I3LHM3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000000383.3\|UniProtKB=F6TZX8	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000009029.6\|UniProtKB=M3WAN6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845029978.1\|UniProtKB=A0A8I3SCI3	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000000573.4\|UniProtKB=A0A5F8G979	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000014354.3\|UniProtKB=F6WE44	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010022623.1\|UniProtKB=A0A8V0ZIW3	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010889.4\|UniProtKB=A0A803TXW5	Anolis carolinensis	O
XENLA\|Gene=top1\|UniProtKB=P41512	Xenopus laevis	O
XENLA\|Gene=top1.1.L\|UniProtKB=A0A1L8EU24	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-950002\|UniProtKB=A0A6I8QED0	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000009314.2\|UniProtKB=H2LZV7	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000013917.2\|UniProtKB=H2MFS5	Oryzias latipes	O
DANRE\|Gene=top1\|UniProtKB=A0A8M1RL46	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-060616-217\|UniProtKB=Q1ED17	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004545.1\|UniProtKB=W5MAN7	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000003086.3\|UniProtKB=F6RCY1	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417267\|UniProtKB=A0A9J7L9R5	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC588512\|UniProtKB=A0A7M7N5Q1	Strongylocentrotus purpuratus	LDO
CAEBR\|Gene_ORFName=CBG20349\|UniProtKB=A8XXL4	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00098809\|UniProtKB=A0A8R1U710	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0004924\|UniProtKB=P30189	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP004078\|UniProtKB=Q7QH57	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC010428\|UniProtKB=D6WKN0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_109061\|UniProtKB=E9H1X3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG79183\|UniProtKB=T1G3L2	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG85509\|UniProtKB=T1G5Y2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g122680\|UniProtKB=A7SLG4	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG30199\|UniProtKB=B3S6N7	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_33512\|UniProtKB=A9V5T5	Monosiga brevicollis	LDO
YEAST\|SGD=S000005366\|UniProtKB=P04786	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ACL008C\|UniProtKB=Q75CB7	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000177495\|UniProtKB=A0A1D8PPI2	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D26103g\|UniProtKB=Q6C7R2	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_00253\|UniProtKB=Q5BGS7	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_1G03500\|UniProtKB=Q4WK70	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09118\|UniProtKB=V5IQ16	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_10018\|UniProtKB=A7EXF7	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_04654\|UniProtKB=Q0UUB0	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC1703.14c\|UniProtKB=P07799	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_05193\|UniProtKB=B6JVY3	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNI03280\|UniProtKB=Q5KB99	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05101\|UniProtKB=P41511	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_10211\|UniProtKB=E3KJL6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_16830\|UniProtKB=F4P4H2	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0283205\|UniProtKB=Q54RC3	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_50979\|UniProtKB=F1A1A6	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_04_0060\|UniProtKB=Q95Z89	Leishmania major	O
TRYB2\|Gene_ORFName=Tb09.160.5070\|UniProtKB=Q38EP5	Trypanosoma brucei	O
LEIMA\|EnsemblGenome=LMJF_34_3440\|UniProtKB=Q4Q2K0	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.4.1330\|UniProtKB=Q581U8	Trypanosoma brucei	LDO
PLAF7\|EnsemblGenome=PF3D7_0510500\|UniProtKB=Q8I3Z9	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00037883001\|UniProtKB=A0CF77	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018012001\|UniProtKB=A0DKX8	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_9772\|UniProtKB=B8CC91	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3G762_PHYRM\|UniProtKB=H3G762	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_03g178600v5\|UniProtKB=A0A2K3DXL6	Chlamydomonas reinhardtii	LDO
SELML\|EnsemblGenome=SELMODRAFT_145504\|UniProtKB=D8RB80	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_151078\|UniProtKB=D8RYE8	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c13_14620\|UniProtKB=A0A2K1JLY5	Physcomitrella patens	LDO
AMBTC\|EnsemblGenome=AMTR_s00059p00193620\|UniProtKB=U5D5F4	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_8G01920\|UniProtKB=A0A0K9NK99	Zostera marina	O
MUSAM\|EnsemblGenome=Ma01_g12750\|UniProtKB=A0A804HTE3	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma04_g26020\|UniProtKB=A0A804ITZ6	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma07_g06370\|UniProtKB=A0A804JSU4	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_013227mg\|UniProtKB=K3YG59	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3007G043500\|UniProtKB=A0A1Z5R8J9	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb172650\|UniProtKB=A0A804NN01	Zea mays	O
ORYSJ\|EnsemblGenome=Os08g0154600\|UniProtKB=Q84ZL5	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_5g24917v3\|UniProtKB=A0A2K2CJ64	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0201870\|UniProtKB=A0A8I7B884	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2B02G525600\|UniProtKB=A0A3B6CEA3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G495200\|UniProtKB=A0A3B6B7F3	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G523400\|UniProtKB=A0A3B6CEA2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G497300\|UniProtKB=A0A3B6B6S2	Triticum aestivum	O
BRADI\|EnsemblGenome=BRADI_3g16920v3\|UniProtKB=I1I1J8	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.7HG0700250\|UniProtKB=A0A287WU39	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS7B02G202300\|UniProtKB=A0A3B6SK37	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7D02G297500\|UniProtKB=A0A3B6TRW0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G302200\|UniProtKB=A0A3B6RK19	Triticum aestivum	O
NELNU\|Gene=LOC104594162\|UniProtKB=A0A1U7ZUI9	Nelumbo nucifera	O
NELNU\|Gene_ORFName=HUJ06_016728\|UniProtKB=A0A1U8ALA9	Nelumbo nucifera	O
SPIOL\|Gene=LOC110789302\|UniProtKB=A0A9R0IHZ8	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0006921\|UniProtKB=A0A251VM83	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100049300\|UniProtKB=A0A9R1XSL9	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0754031\|UniProtKB=A0A251S005	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400180460\|UniProtKB=A0A9R1VVM9	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a001121mg\|UniProtKB=A0A022QT09	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_19906\|UniProtKB=A0A2G2Z352	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400001083\|UniProtKB=M0ZKN5	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc07g049720.3\|UniProtKB=A0A3Q7HDM5	Solanum lycopersicum	O
TOBAC\|Gene=LOC107830452\|UniProtKB=A0A1S4DJA8	Nicotiana tabacum	O
TOBAC\|Gene=LOC107801727\|UniProtKB=A0A1S4AV86	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi19g01624\|UniProtKB=D7SWQ4	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi12g00353\|UniProtKB=F6HIA5	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_C00402\|UniProtKB=A0A059CKT7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00013005001\|UniProtKB=A0A078G7Z3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00013006001\|UniProtKB=A0A078G5V1	Brassica napus	O
BRACM\|EnsemblGenome=Bra035567\|UniProtKB=M4F3B7	Brassica campestris	O
ARATH\|TAIR=locus=2173852\|UniProtKB=P30181	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=GSBRNA2T00009684001\|UniProtKB=A0A078G3G3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00095411001\|UniProtKB=A0A078FX55	Brassica napus	O
BRACM\|EnsemblGenome=Bra002917\|UniProtKB=M4CFD5	Brassica campestris	O
ARATH\|TAIR=locus=2173862\|UniProtKB=Q9FJ79	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107903422\|UniProtKB=A0A1U8J3R4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107932759\|UniProtKB=A0A1U8M0M5	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_030764\|UniProtKB=A0A061F4G5	Theobroma cacao	O
POPTR\|Gene_ORFName=POPTR_011G092700\|UniProtKB=A0A3N7FR54	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_001G359700v3\|UniProtKB=A0A2K2C974	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_03G135300\|UniProtKB=A0A2C9W9Q6	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G065000\|UniProtKB=A0A2C9UEH9	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0045870\|UniProtKB=B9SSQ1	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_09G223300\|UniProtKB=I1L5G9	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G013600\|UniProtKB=I1LP26	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g114260\|UniProtKB=G7J5B6	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_1g040355\|UniProtKB=A0A072VH94	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g114350\|UniProtKB=G7J5C3	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g114150\|UniProtKB=G7J5A8	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_0172s0010\|UniProtKB=A0A072TSF3	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_25130\|UniProtKB=A0A2I4DYV8	Juglans regia	O
JUGRE\|EnsemblGenome=Jr09_15830\|UniProtKB=A0A2I4EZG9	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G063680\|UniProtKB=A0A0A0L2W2	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G146000\|UniProtKB=A0A251QXP4	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_8G003200\|UniProtKB=M5W6I9	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_156783\|UniProtKB=D8SMX1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_109207\|UniProtKB=D8S5X0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_152781\|UniProtKB=D8S5V9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c3_12300\|UniProtKB=A0A2K1KU92	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0167s0020\|UniProtKB=A0A2R6W3B0	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000610370\|UniProtKB=A0A0U9HRA6	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1322\|UniProtKB=A9A2H9	Nitrosopumilus maritimus	LDO