PANTHER Gene Information

Gene Symbol(s):

CYP2E1

Organism:

Bos taurus

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Gene Name:

Cytochrome P450 2E1

Gene ID:

CYP2E1

Protein ID:

O18963

Persistent Id:

PTN002802075

Alternate Ids:

282213(GeneID)	4-nitrophenol 2-hydroxylase(Synonym)
Q4PS78(AltAccession)	CP2E1_BOVIN(UniProtKB-ID)
1.14.13.n7 {ECO:0000250\|UniProtKB:P05181}(EC)	NP_776955(refSeq)
CAA04948(EMBL-CDS)	2511605(GI)
CYP2E1(Symbol)	DQ058605(EMBL)
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PANTHER Classification

PANTHER Family:	CYTOCHROME P450 508A4-RELATED (PTHR24300)
PANTHER Subfamily:	CYTOCHROME P450 2E1 (PTHR24300:SF356)
PANTHER GO-slim Molecular Function:	monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
PANTHER GO-slim Biological Process:	long-chain fatty acid metabolic process cellular response to chemical stimulus icosanoid metabolic process unsaturated fatty acid metabolic process
PANTHER GO-slim Cellular Component:	cytoplasm intracellular membrane-bounded organelle
PANTHER protein class:	oxygenase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	arachidonate epoxygenase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, iron ion binding, Hsp90 protein binding, heme binding, Hsp70 protein binding
GO BP Complete:	epoxygenase P450 pathway, xenobiotic metabolic process
GO CC Complete:	endoplasmic reticulum membrane, cytoplasm, intracellular membrane-bounded organelle, mitochondrial inner membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2631\|UniProtKB=P05181	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000003099.4\|UniProtKB=A0A2J8J1H0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002962.3\|UniProtKB=G3QKD9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000050538.1\|UniProtKB=A0A5F7ZHU3	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000006339.4\|UniProtKB=A0A1D5R8W3	Macaca mulatta	LDO
MACMU\|Gene=CYP2E1\|UniProtKB=Q6GUQ4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88607\|UniProtKB=Q05421	Mus musculus	LDO
RAT\|RGD=2475\|UniProtKB=P05182	Rattus norvegicus	LDO
PIG\|Gene=CYP2E1\|UniProtKB=P79383	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000010780.5\|UniProtKB=F1SCT4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000019088.4\|UniProtKB=F7DJ72	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013762.6\|UniProtKB=A0A2I2UZN5	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00000013311\|UniProtKB=Q9MZY0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010247.4\|UniProtKB=F6W669	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000045753.1\|UniProtKB=A0A6I8N554	Ornithorhynchus anatinus	LDO
CHICK\|Gene=CYP2H1\|UniProtKB=P05180	Gallus gallus	LDO
CHICK\|Gene=CYP2H2\|UniProtKB=P20678	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010020676.1\|UniProtKB=A0A8V0ZE63	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010021763.1\|UniProtKB=A0A8V0ZM72	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010023886.1\|UniProtKB=A0A8V0ZUT1	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010182.4\|UniProtKB=G1KK45	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000022573.3\|UniProtKB=L7MZT3	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000014531.4\|UniProtKB=A0A803TQ09	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000029195.2\|UniProtKB=A0A803TKI6	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000003630.4\|UniProtKB=A0A803TB24	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000027231.2\|UniProtKB=H9GTD1	Anolis carolinensis	LDO
XENLA\|Gene=LOC108701176\|UniProtKB=A0A1L8EUR3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5919980\|UniProtKB=F6XRR5	Xenopus tropicalis	O
XENLA\|Gene=MGC68450\|UniProtKB=Q6PAG4	Xenopus laevis	O
XENLA\|Gene=cyp2a6.1.S\|UniProtKB=Q7ZX81	Xenopus laevis	O
XENLA\|Gene=cyp2a6.1.L\|UniProtKB=A0A1L8F926	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000044535\|UniProtKB=F6YP15	Xenopus tropicalis	O
XENLA\|Gene=cyp2a6.12.L\|UniProtKB=A0A8J0THD5	Xenopus laevis	O
XENLA\|Gene=cyp2a6.11.S\|UniProtKB=A0A1L8F3W3	Xenopus laevis	LDO
XENTR\|Gene=LOC116406635\|UniProtKB=A0A8J1IMX8	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001225.2\|UniProtKB=A0A3B3HB37	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000001238.2\|UniProtKB=A0A3B3I0D4	Oryzias latipes	O
DANRE\|Gene=si=zfos-411a11.2\|UniProtKB=A0A8M6YUY2	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050522-490\|UniProtKB=Q4VBR9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010655.1\|UniProtKB=W5MXF0	lepisosteus oculatus	O
CAEEL\|WormBase=WBGene00007913\|UniProtKB=P90771	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00026819\|UniProtKB=A8WW56	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00094501\|UniProtKB=A0A8R1Y7A5	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00098125\|UniProtKB=A0A454XRQ2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00284156\|UniProtKB=A0A2A6CKC1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00096193\|UniProtKB=A0A2A6CME8	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00100674\|UniProtKB=A0A2A6BLU9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00100368\|UniProtKB=A0A2A6CNE7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00274158\|UniProtKB=A0A2A6BNU3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115359\|UniProtKB=A0A2A6CNT1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115644\|UniProtKB=A0A2A6BLK1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277971\|UniProtKB=A0A2A6CEQ5	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00100681\|UniProtKB=A0A2A6CJP7	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00098124\|UniProtKB=A0A2A6BLN1	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015135\|UniProtKB=Q27465	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00034232\|UniProtKB=A8XHN9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00097800\|UniProtKB=A0A2A6BZL5	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00011698\|UniProtKB=O62378	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011699\|UniProtKB=O62377	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038021\|UniProtKB=A8XTS5	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00015040\|UniProtKB=O44655	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024531\|UniProtKB=A8WQ01	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00015400\|UniProtKB=O02628	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015399\|UniProtKB=O02627	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019565\|UniProtKB=Q9N5I1	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019473\|UniProtKB=O44649	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00016786\|UniProtKB=O16220	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01388\|UniProtKB=A8WQA7	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00032566\|UniProtKB=A8XCZ4	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00024637\|UniProtKB=A8WQA9	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00015041\|UniProtKB=O44656	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015043\|UniProtKB=O44658	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015042\|UniProtKB=O44657	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00015044\|UniProtKB=H2KY69	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01271\|UniProtKB=A8WQ03	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG01339\|UniProtKB=A8WQ64	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00024639\|UniProtKB=A8WQB1	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG01270\|UniProtKB=A8WQ02	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00019470\|UniProtKB=O44652	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019472\|UniProtKB=O44650	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019471\|UniProtKB=O44651	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024632\|UniProtKB=A8WQA4	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00024638\|UniProtKB=A8WQB0	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00015709\|UniProtKB=Q27470	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17010\|UniProtKB=A8XQ93	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00016092\|UniProtKB=Q27471	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19168\|UniProtKB=A8XUZ8	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00008829\|UniProtKB=O45364	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22835\|UniProtKB=A8Y360	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00041296\|UniProtKB=A8Y357	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00016686\|UniProtKB=O44704	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00016697\|UniProtKB=O44706	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00030566\|UniProtKB=A8X7I8	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG21837\|UniProtKB=A8Y0X9	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00040506\|UniProtKB=A8Y0W6	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00018334\|UniProtKB=Q27499	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00016768\|UniProtKB=Q27482	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00026374\|UniProtKB=A8WV77	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG03499\|UniProtKB=A8WV94	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00018262\|UniProtKB=O16670	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00019967\|UniProtKB=O02641	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00018261\|UniProtKB=O16671	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00018264\|UniProtKB=A0A0M7RF98	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00018413\|UniProtKB=O16362	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024506\|UniProtKB=A8WPX6	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG01236\|UniProtKB=A8WPX1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021168\|UniProtKB=Q9N4Q4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01257\|UniProtKB=A8WPZ0	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00015045\|UniProtKB=O61204	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024534\|UniProtKB=A8WQ04	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00007362\|UniProtKB=G5ECD0	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG11445\|UniProtKB=A8XD01	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00010589\|UniProtKB=O45659	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00012448\|UniProtKB=G5EE22	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00029469\|UniProtKB=A8X4U1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020386\|UniProtKB=O61935	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024530\|UniProtKB=A8WQ00	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00016860\|UniProtKB=O16482	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00021710\|UniProtKB=Q965T7	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00018260\|UniProtKB=O16673	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG06337\|UniProtKB=A8X201	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG06602\|UniProtKB=A8X2M4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00095332\|UniProtKB=A0A2A6C4I1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00091774\|UniProtKB=A0A8R1YBK8	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00101192\|UniProtKB=A0A2A6BY51	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00284432\|UniProtKB=A0A2A6BX43	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00280176\|UniProtKB=A0A2A6CNR8	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115306\|UniProtKB=A0A2A6BJ45	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00100939\|UniProtKB=A0A2A6C207	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00115307\|UniProtKB=A0A2A6BJ16	Pristionchus pacificus	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234969\|UniProtKB=A7S5T4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g204234\|UniProtKB=A7RYZ5	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g208281\|UniProtKB=A7S865	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g171703\|UniProtKB=A7SKW0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g164344\|UniProtKB=A7RYZ4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g143569\|UniProtKB=A7T2W8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g122119\|UniProtKB=A7SKW3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g122140\|UniProtKB=A7SKW2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g231218\|UniProtKB=A7SZN0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g227345\|UniProtKB=A7SNF8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g60849\|UniProtKB=A7RWT2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g238893\|UniProtKB=A7RK94	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g82634\|UniProtKB=A7RI92	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g209361\|UniProtKB=A7SAR4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g221914\|UniProtKB=A7T3R2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g107875\|UniProtKB=A7S7U4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g161477\|UniProtKB=A7RQ60	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g13146\|UniProtKB=A7S7V0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g182833\|UniProtKB=A7RWT1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g217770\|UniProtKB=A7SUQ2	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g235065\|UniProtKB=A7S7U0	Nematostella vectensis	O
DICDI\|dictyBase=DDB_G0272704\|UniProtKB=Q86A22	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_42091\|UniProtKB=F1A1D7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0271778\|UniProtKB=Q55AJ4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_92019\|UniProtKB=F0ZKM6	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282283\|UniProtKB=Q54SV9	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_81297\|UniProtKB=F0ZT26	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_99050\|UniProtKB=F0ZVS1	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0286743\|UniProtKB=Q54LA8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_17677\|UniProtKB=F0ZHS5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282769\|UniProtKB=Q1ZXG3	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0292168\|UniProtKB=Q54DT2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_153109\|UniProtKB=F0ZN31	Dictyostelium purpureum	O