PANTHER Gene Information

Gene Symbol(s):

nep-4

Organism:

Caenorhabditis elegans

View Gene in Tree


Tree	Reduced Tree

Gene Name:

Peptidase M13 C-terminal domain-containing protein

Gene ID:

WBGene00016896

Protein ID:

O45311

Persistent Id:

PTN000200044

Alternate Ids:

351060253(GI)	NM_076755(refSeq)
WBGene00016896(WormBase)	183746(GeneID)
C53B7(WormBase_TRS)	CE35438(WormBase_PRO)
BX284606(EMBL)	O45311(Synonym)
WBGene00016896(Ensembl)	CCD67890(EMBL-CDS)
O45311_CAEEL(UniProtKB-ID)
Show All

PANTHER Classification

PANTHER Family:	ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED (PTHR11733)
PANTHER Subfamily:	PEPTIDASE M13 C-TERMINAL DOMAIN-CONTAINING PROTEIN (PTHR11733:SF208)
PANTHER GO-slim Molecular Function:	metalloendopeptidase activity
PANTHER GO-slim Biological Process:	protein processing
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	metalloprotease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	metalloendopeptidase activity, metallopeptidase activity
GO BP Complete:	proteolysis, protein processing
GO CC Complete:	plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Physiological factors, Metabolism of Angiotensinogen to Angiotensins, Neutrophil degranulation, Innate Immune System, Peptide hormone metabolism, Immune System, Muscle contraction, Cardiac conduction, Metabolism of proteins

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8918\|UniProtKB=P78562	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021737.4\|UniProtKB=H2QYE4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000036211.1\|UniProtKB=A0A2I2YJK6	Gorilla gorilla gorilla	O
GORGO\|Ensembl=ENSGGOG00000003961.3\|UniProtKB=G3QMZ2	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000023589.4\|UniProtKB=F7HFQ1	Macaca mulatta	O
MOUSE\|MGI=MGI=107489\|UniProtKB=P70669	Mus musculus	O
RAT\|RGD=3323\|UniProtKB=G3V723	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000000419.5\|UniProtKB=E1BKS5	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000012167.4\|UniProtKB=F1SQ05	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000011455.4\|UniProtKB=F6ZQA0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000023221.4\|UniProtKB=M3WSX1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845029993.1\|UniProtKB=A0A8I3Q891	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000007861.4\|UniProtKB=F7EBG3	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000010653.3\|UniProtKB=F6XSA3	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003252.1\|UniProtKB=A0A8V0XFU9	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007524.4\|UniProtKB=A0A803TY88	Anolis carolinensis	O
XENLA\|Gene=phex.S\|UniProtKB=A0A1L8H612	Xenopus laevis	O
XENLA\|Gene=phex.L\|UniProtKB=A0A1L8HDK6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1012247\|UniProtKB=A0A6I8RG47	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000014048.2\|UniProtKB=H2MG84	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030103-2\|UniProtKB=F1R6K1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003780.1\|UniProtKB=W5M818	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000014061.2\|UniProtKB=F6PUF3	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000004627.3\|UniProtKB=F6PTZ3	Ciona intestinalis	O
BRAFL\|Gene=LOC118423057\|UniProtKB=A0A9J7N213	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC575956\|UniProtKB=A0A7M7R9K5	Strongylocentrotus purpuratus	O
CAEBR\|WormBase=WBGene00032164\|UniProtKB=A8XC98	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00032159\|UniProtKB=A8XC93	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00032163\|UniProtKB=A8XC97	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG22755\|UniProtKB=A8Y336	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00281762\|UniProtKB=A0A2A6BU78	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277683\|UniProtKB=A0A2A6BK67	Pristionchus pacificus	LDO
PRIPA\|EnsemblGenome=WBGene00277699\|UniProtKB=A0A2A6BK74	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277720\|UniProtKB=A0A2A6BJZ4	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00275378\|UniProtKB=A0A2A6BGH9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00204323\|UniProtKB=A0A2A6BJF9	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109121\|UniProtKB=A0A2A6BJY3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00109280\|UniProtKB=A0A2A6BJV6	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00277718\|UniProtKB=A0A2A6BJQ2	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00204374\|UniProtKB=A0A2A6BK76	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0039478\|UniProtKB=Q8IMQ2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002441\|UniProtKB=A0A1S4GF43	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC009013\|UniProtKB=D6WPW1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC008205\|UniProtKB=D2A0F3	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC010845\|UniProtKB=D6W7L0	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW023236\|UniProtKB=B7QMB3	Ixodes scapularis	O
DROME\|FlyBase=FBgn0027570\|UniProtKB=A0A0B4K692	Drosophila melanogaster	O
TRICA\|EnsemblGenome=TC013112\|UniProtKB=D6WNY2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033234\|UniProtKB=A0A139WHC8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC000565\|UniProtKB=D6W9K2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC014700\|UniProtKB=D6WNX8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006174\|UniProtKB=D6WV10	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC014701\|UniProtKB=D6WNX9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033258\|UniProtKB=A0A139WHP0	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_187662\|UniProtKB=E9G559	Daphnia pulex	O
DROME\|FlyBase=FBgn0039611\|UniProtKB=Q9VAS2	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0039612\|UniProtKB=Q9VAS1	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0030425\|UniProtKB=Q9VYJ1	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0039024\|UniProtKB=Q9VCU1	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0039609\|UniProtKB=Q9VAS4	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0039613\|UniProtKB=Q9VAS0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0027578\|UniProtKB=Q9Y136	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0038818\|UniProtKB=Q8T062	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP003106\|UniProtKB=Q7PQR4	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034528\|UniProtKB=A0A139WP90	Tribolium castaneum	O
DROME\|FlyBase=FBgn0039564\|UniProtKB=Q9VAY0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0037727\|UniProtKB=Q9VH96	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0033742\|UniProtKB=A1Z910	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0029843\|UniProtKB=Q9W436	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009791\|UniProtKB=A0A1S4H2V0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC011972\|UniProtKB=D6X2U0	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_192377\|UniProtKB=E9FZ03	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG177711\|UniProtKB=T1FC43	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG175054\|UniProtKB=T1F8S6	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG177705\|UniProtKB=T1FC41	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG177709\|UniProtKB=T1FC42	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG187798\|UniProtKB=T1FPD8	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g229362\|UniProtKB=A7S4D9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG37639\|UniProtKB=B3RTH7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG63323\|UniProtKB=B3RZU7	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_03091\|UniProtKB=C8VIN1	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G12420\|UniProtKB=Q4WYB2	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_05697\|UniProtKB=A7EK51	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_15353\|UniProtKB=Q0TYS9	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNB04230\|UniProtKB=Q5KLS5	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02693\|UniProtKB=A0A0D1C704	Ustilago maydis	O
THAPS\|EnsemblGenome=THAPSDRAFT_269863\|UniProtKB=B8LCF9	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GEF2_PHYRM\|UniProtKB=H3GEF2	Phytophthora ramorum	O
PHYRM\|Gene=H3HBZ9_PHYRM\|UniProtKB=H3HBZ9	Phytophthora ramorum	O
PHYRM\|Gene=H3H7F1_PHYRM\|UniProtKB=H3H7F1	Phytophthora ramorum	O
KLENI\|Gene_ORFName=KFL_000670270\|UniProtKB=A0A1Y1HUV6	Klebsormidium nitens	O
METAC\|EnsemblGenome=MA_2001\|UniProtKB=Q8TPB2	Methanosarcina acetivorans	O
MYCTU\|Gene_OrderedLocusName=Rv0198c\|UniProtKB=I6X8R2	Mycobacterium tuberculosis	O
STRR6\|EnsemblGenome=spr1491\|UniProtKB=Q8DNW9	Streptococcus pneumoniae	O
BACTN\|EnsemblGenome=BT_3811\|UniProtKB=Q8A156	Bacteroides thetaiotaomicron	O
SHEON\|Gene_OrderedLocusName=SO_0429\|UniProtKB=Q8EJN4	Shewanella oneidensis	O
SHEON\|Gene_OrderedLocusName=SO_3844\|UniProtKB=Q8EAQ3	Shewanella oneidensis	O
RHOBA\|EnsemblGenome=RB9029\|UniProtKB=Q7UM68	Rhodopirellula baltica	O
SHEON\|Gene_OrderedLocusName=SO_0491\|UniProtKB=Q8EJH4	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC3671\|UniProtKB=Q8P4N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2710\|UniProtKB=Q8P7A3	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2035\|UniProtKB=Q8P931	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2575\|UniProtKB=Q8P7N6	Xanthomonas campestris	O
XANCP\|EnsemblGenome=XCC2574\|UniProtKB=Q8P7N7	Xanthomonas campestris	O