PANTHER Gene Information   
Gene Symbol(s): Pde5a
Organism: Rattus norvegicus
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Gene Name: cGMP-specific 3',5'-cyclic phosphodiesterase
Gene ID: 620995
Protein ID: O54735
Persistent Id: PTN000142161
Alternate Ids:
Pde5a(Symbol) CGB-PDE(Synonym)
171115(GeneID) 620995(RGD)
5921804(GI) BAA23672(EMBL-CDS)
3.1.4.35 {ECO:0000250|UniProtKB:O76074}(EC) D89093(EMBL)
CHEMBL4567(ChEMBL) PDE5A_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PTHR11347)
PANTHER Subfamily: PHOSPHODIESTERASE (PTHR11347:SF20)  
PANTHER GO-slim Molecular Function: cyclic-nucleotide phosphodiesterase activity
PANTHER GO-slim Biological Process: cAMP-mediated signaling
PANTHER GO-slim Cellular Component:
PANTHER protein class: phosphodiesterase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity, metal ion binding, calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, cGMP binding, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity
GO BP Complete: positive regulation of MAP kinase activity, positive regulation of oocyte development, signal transduction, positive regulation of vasoconstriction, nervous system development, vasodilation, regulation of the force of heart contraction, short-term memory, response to hypoxia, positive regulation of chronic inflammatory response, cGMP metabolic process, oocyte development, cGMP catabolic process, regulation of nitric oxide mediated signal transduction, negative regulation of T cell proliferation, T cell proliferation, positive regulation of apoptotic process, positive regulation of cardiac muscle hypertrophy, response to lipopolysaccharide, response to testosterone, cAMP-mediated signaling, negative regulation of cardiac muscle contraction, relaxation of cardiac muscle
GO CC Complete: -
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: RHO GTPase cycle, Smooth Muscle Contraction, Muscle contraction, Hemostasis, Platelet homeostasis, Signaling by Rho GTPases, Nitric oxide stimulates guanylate cyclase, cGMP effects, Signal Transduction, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Orthologs