PANTHER Gene Information   
Gene Symbol(s): Pli
Organism: Drosophila melanogaster
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Gene Name: Protein pellino
Gene ID: FBgn0025574
Protein ID: O77237
Persistent Id: PTN000250583
Alternate Ids:
PELI(Synonym) FBtr0112907(Ensembl_TRS)
NM_001104420(refSeq) AF091624(EMBL)
42821(GeneID) PELI_DROME(UniProtKB-ID)
FBpp0111820(Ensembl_PRO) FBgn0025574(FlyBase)
AAF56198(EMBL-CDS) Pli(Symbol)
37999357(GI) FBgn0025574(Ensembl)
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PANTHER Classification
PANTHER Family: E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED (PTHR12098)
PANTHER Subfamily: PROTEIN PELLINO (PTHR12098:SF2)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
PANTHER GO-slim Biological Process: protein polyubiquitination
PANTHER GO-slim Cellular Component:
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, ubiquitin protein ligase activity, protein binding, kinase regulator activity
GO BP Complete: negative regulation of antifungal innate immune response, positive regulation of antimicrobial peptide production, protein K48-linked ubiquitination, protein polyubiquitination, innate immune response, regulation of Toll signaling pathway, negative regulation of Toll signaling pathway, positive regulation of Toll signaling pathway, negative regulation of defense response to bacterium
GO CC Complete: cytosol, cytoplasmic side of plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Toll Like Receptor TLR6:TLR2 Cascade, IRAK1 recruits IKK complex, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 10 (TLR10) Cascade, Interleukin-1 family signaling, Toll Like Receptor 9 (TLR9) Cascade, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, Toll Like Receptor 7/8 (TLR7/8) Cascade, Signaling by Interleukins, Interleukin-1 signaling, Cytokine Signaling in Immune system, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 4 (TLR4) Cascade, Innate Immune System, Toll-like Receptor Cascades, Toll Like Receptor 2 (TLR2) Cascade

Orthologs