PANTHER Gene Information   
Gene Symbol(s): Psmd1
Organism: Rattus norvegicus
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Gene Name: 26S proteasome non-ATPase regulatory subunit 1
Gene ID: 621669
Protein ID: O88761
Persistent Id: PTN000101682
Alternate Ids:
PSMD1(Synonym) 83806(GeneID)
NP_114184(refSeq) PSMD1_RAT(UniProtKB-ID)
Psmd1(Symbol) 14010879(GI)
CAA06983(EMBL-CDS) AJ006340(EMBL)
621669(RGD) CHEMBL2176782(ChEMBL)
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PANTHER Classification
PANTHER Family: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT (PTHR10943)
PANTHER Subfamily: 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1 (PTHR10943:SF2)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: proteasome regulatory particle
nucleus
intracellular non-membrane-bounded organelle
cytoplasm
PANTHER protein class: protease
Pathway Categories: Ubiquitin proteasome pathway
   26S proteasome
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin protein ligase binding, enzyme regulator activity
GO BP Complete: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process
GO CC Complete: nucleus, proteasome regulatory particle, base subcomplex, proteasome complex, proteasome accessory complex, proteasome storage granule
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: p53-Dependent G1 DNA Damage Response, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Cyclin E associated events during G1/S transition , Antigen processing-Cross presentation, Cellular response to chemical stress, Signaling by WNT, Assembly of the pre-replicative complex, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Activation of NF-kappaB in B cells, Mitotic Anaphase, Degradation of AXIN, Cell Cycle, M Phase, Degradation of DVL, p53-Independent DNA Damage Response, MAPK6/MAPK4 signaling, PCP/CE pathway, Switching of origins to a post-replicative state, Cross-presentation of soluble exogenous antigens (endosomes), APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Generic Transcription Pathway, Autodegradation of the E3 ubiquitin ligase COP1, G1/S Transition, Signaling by the B Cell Receptor (BCR), Adaptive Immune System, Cytokine Signaling in Immune system, Signaling by Hedgehog, MAPK family signaling cascades, Cell Cycle Checkpoints, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Cellular responses to stimuli, KEAP1-NFE2L2 pathway, Transcriptional regulation by RUNX3, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, p53-Dependent G1/S DNA damage checkpoint, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, TNFR2 non-canonical NF-kB pathway, Innate Immune System, G1/S DNA Damage Checkpoints, p53-Independent G1/S DNA damage checkpoint, Autodegradation of Cdh1 by Cdh1:APC/C, Metabolism of polyamines, Hedgehog ligand biogenesis, UCH proteinases, Regulation of PTEN stability and activity, Regulation of APC/C activators between G1/S and early anaphase, APC/C:Cdc20 mediated degradation of mitotic proteins, C-type lectin receptors (CLRs), SCF-beta-TrCP mediated degradation of Emi1, Mitotic G1 phase and G1/S transition, Regulation of mitotic cell cycle, Transport of small molecules, Mitotic G2-G2/M phases, ABC-family proteins mediated transport, Hedgehog 'on' state, Dectin-1 mediated noncanonical NF-kB signaling, DNA Replication Pre-Initiation, Transcriptional regulation by RUNX1, Cellular responses to stress, S Phase, SCF(Skp2)-mediated degradation of p27/p21, TCF dependent signaling in response to WNT, CLEC7A (Dectin-1) signaling, G2/M Checkpoints, PTEN Regulation, Separation of Sister Chromatids, Degradation of GLI1 by the proteasome, Synthesis of DNA, APC/C-mediated degradation of cell cycle proteins, Orc1 removal from chromatin, Metabolism of amino acids and derivatives, Gene expression (Transcription), GLI3 is processed to GLI3R by the proteasome, Cyclin A:Cdk2-associated events at S phase entry, CDK-mediated phosphorylation and removal of Cdc6, Regulation of RAS by GAPs, Mitotic Metaphase and Anaphase, Beta-catenin independent WNT signaling, Metabolism of proteins, RNA Polymerase II Transcription, Degradation of beta-catenin by the destruction complex, Regulation of RUNX3 expression and activity, Immune System, Asymmetric localization of PCP proteins, Downstream signaling events of B Cell Receptor (BCR), Regulation of ornithine decarboxylase (ODC), Stabilization of p53, Deubiquitination, Cellular response to hypoxia, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Metabolism of RNA, PIP3 activates AKT signaling, AUF1 (hnRNP D0) binds and destabilizes mRNA, Neutrophil degranulation, Regulation of mRNA stability by proteins that bind AU-rich elements, Ub-specific processing proteases, Cell Cycle, Mitotic, NIK-->noncanonical NF-kB signaling, MAPK1/MAPK3 signaling, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, Hedgehog 'off' state, G2/M Transition, Neddylation, The role of GTSE1 in G2/M progression after G2 checkpoint, Signal Transduction, RAF/MAP kinase cascade, Post-translational protein modification, Ubiquitin-dependent degradation of Cyclin D, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Metabolism, Class I MHC mediated antigen processing & presentation, Antigen processing: Ubiquitination & Proteasome degradation, Intracellular signaling by second messengers, DNA Replication, APC/C:Cdc20 mediated degradation of Securin, Nuclear events mediated by NFE2L2

Orthologs