PANTHER Gene Information   
Gene Symbol(s): PRKACA
Organism: Bos taurus
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Gene Name: cAMP-dependent protein kinase catalytic subunit alpha
Gene ID: ENSBTAG00000006642
Protein ID: P00517
Persistent Id: PTN007797477
Alternate Ids:
282322(GeneID) 40889424(GI)
CHEMBL2654(ChEMBL) KAPCA(Synonym)
X67154(EMBL) CAA47627(EMBL-CDS)
ENSBTAT00000085342(Ensembl_TRS) ENSBTAG00000006642(Ensembl)
ENSBTAP00000063436(Ensembl_PRO) KAPCA_BOVIN(UniProtKB-ID)
PRKACA(Symbol) 2.7.11.11(EC)
NM_174584(refSeq)
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PANTHER Classification
PANTHER Family: CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE (PTHR24353)
PANTHER Subfamily: CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (PTHR24353:SF82)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
protein kinase A regulatory subunit binding
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component: cytosol
serine/threonine protein kinase complex
intracellular protein-containing complex
nucleus
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Inflammation mediated by chemokine and cytokine signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group II pathway
   Protein kinase A
GABA-B receptor II signaling
   Protein kinase A
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
   Protein kinase A
CCKR signaling map
   PKA-Calpha/beta/gamma
Endothelin signaling pathway
   Protein kinase A
Enkephalin release
   Protein kinase A
Beta1 adrenergic receptor signaling pathway
   Protein kinase A
Histamine H2 receptor mediated signaling pathway
   Protein kinase A
Beta2 adrenergic receptor signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group I pathway
   Protein kinase A
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Protein kinase A, catalytic subunit
Nicotine pharmacodynamics pathway
   cAMP-dependent protein kinase catalytic subunit alpha
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
   Protein kinase A
5HT1 type receptor mediated signaling pathway
   Protein kinase A
Dopamine receptor mediated signaling pathway
   Protein kinase A
Metabotropic glutamate receptor group III pathway
   Protein kinase A
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, protein domain specific binding, cAMP-dependent protein kinase activity, protein kinase activity, protein serine/threonine kinase activity, magnesium ion binding, ATP binding, protein serine/threonine/tyrosine kinase activity, protein binding, ubiquitin protein ligase binding, protein kinase A regulatory subunit binding, manganese ion binding, protein serine kinase activity
GO BP Complete: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, regulation of proteasomal protein catabolic process, positive regulation of cholesterol biosynthetic process, postsynaptic modulation of chemical synaptic transmission, protein phosphorylation, regulation of osteoblast differentiation, positive regulation of gluconeogenesis, negative regulation of glycolytic process through fructose-6-phosphate, cellular response to heat, sperm capacitation, neural tube closure, cellular response to glucose stimulus, cellular response to glucagon stimulus, cellular response to parathyroid hormone stimulus, mesoderm formation, positive regulation of insulin secretion, regulation of cell cycle, regulation of bicellular tight junction assembly, positive regulation of protein export from nucleus, negative regulation of TORC1 signaling, signal transduction, mRNA processing, adenylate cyclase-activating G protein-coupled receptor signaling pathway, protein export from nucleus, negative regulation of smoothened signaling pathway, protein localization to lipid droplet, peptidyl-serine phosphorylation, cellular response to cold, regulation of protein processing
GO CC Complete: nuclear speck, plasma membrane raft, axoneme, cAMP-dependent protein kinase complex, nucleus, centrosome, perinuclear region of cytoplasm, postsynapse, cytoplasm, acrosomal vesicle, ciliary base, mitochondrion, cytosol, neuromuscular junction, glutamatergic synapse, sperm flagellum
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cytokine Signaling in Immune system, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Adaptive Immune System, Intracellular signaling by second messengers, MAPK6/MAPK4 signaling, Signal Transduction, Activation of NMDA receptors and postsynaptic events, Metabolism, Innate Immune System, G2/M Transition, Hemostasis, Loss of Nlp from mitotic centrosomes, Hedgehog 'off' state, Cell Cycle, Mitotic, GLI3 is processed to GLI3R by the proteasome, HDL assembly, CaM pathway, Ca-dependent events, G-protein mediated events, PLC beta mediated events, AURKA Activation by TPX2, G alpha (i) signalling events, Post NMDA receptor activation events, Cardiac conduction, C-type lectin receptors (CLRs), Immune System, Mitochondrial protein degradation, Recruitment of mitotic centrosome proteins and complexes, Rap1 signalling, Developmental Biology, CREB1 phosphorylation through the activation of Adenylate Cyclase, GPCR downstream signalling, PKA activation in glucagon signalling, Integration of energy metabolism, DAG and IP3 signaling, Glucagon signaling in metabolic regulation, Opioid Signalling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Vasopressin regulates renal water homeostasis via Aquaporins, G alpha (s) signalling events, VEGFA-VEGFR2 Pathway, Muscle contraction, Mitotic Prometaphase, Factors involved in megakaryocyte development and platelet production, CD209 (DC-SIGN) signaling, RET signaling, DARPP-32 events, Loss of proteins required for interphase microtubule organization from the centrosome, Recruitment of NuMA to mitotic centrosomes, Cilium Assembly, Centrosome maturation, Organelle biogenesis and maintenance, Cell Cycle, Aquaporin-mediated transport, PKA-mediated phosphorylation of CREB, Mitotic G2-G2/M phases, M Phase, Anchoring of the basal body to the plasma membrane, Axon guidance, Signaling by Receptor Tyrosine Kinases, Metabolism of proteins, Calmodulin induced events, Plasma lipoprotein assembly, Ion homeostasis, Transport of small molecules, Regulation of PLK1 Activity at G2/M Transition, MAPK family signaling cascades, Regulation of insulin secretion, Signaling by GPCR, PKA activation, Transmission across Chemical Synapses, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Signaling by VEGF, Signaling by Hedgehog, GPER1 signaling, Nervous system development, Plasma lipoprotein assembly, remodeling, and clearance

Orthologs