The mission of the PANTHER knowledgebase is to support biomedical and other research by providing
comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

PANTHER19.0 Released. Click for more details.

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

C4

Organism:

Bos taurus

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Tree

Gene Name:

Complement C4

Gene ID:

C4

Protein ID:

P01030

Persistent Id:

PTN001686231

Alternate Ids:

U16749(EMBL)	AAA52750(EMBL-CDS)
Q27992(AltAccession)	CO4_BOVIN(UniProtKB-ID)
31563307(GI)	C4(Symbol)
CO4(Synonym)
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PANTHER Classification

PANTHER Family:	MACROGLOBULIN / COMPLEMENT (PTHR11412)
PANTHER Subfamily:	COMPLEMENT C4-A-RELATED (PTHR11412:SF86)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	complement activation
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	protease inhibitor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	-
GO BP Complete:	complement activation, inflammatory response, complement activation, classical pathway, innate immune response
GO CC Complete:	dendrite, extracellular space, synapse, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

-

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1324\|UniProtKB=P0C0L5	Homo sapiens	LDO
HUMAN\|HGNC=1323\|UniProtKB=P0C0L4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000046780.1\|UniProtKB=A0A2I3RJ27	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000039460.1\|UniProtKB=A0A2I2ZB59	Gorilla gorilla gorilla	O
GORGO\|Ensembl=ENSGGOG00000043529.1\|UniProtKB=G3RPZ9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000049499.1\|UniProtKB=H9H2P7	Macaca mulatta	LDO
MACMU\|Ensembl=ENSMMUG00000059791.1\|UniProtKB=A0A1D5Q2R8	Macaca mulatta	O
MOUSE\|MGI=MGI=88228\|UniProtKB=P01029	Mus musculus	LDO
RAT\|RGD=1591983\|UniProtKB=Q6MG90	Rattus norvegicus	O
RAT\|RGD=620005\|UniProtKB=P08649	Rattus norvegicus	LDO
PIG\|Ensembl=ENSSSCG00000001427.6\|UniProtKB=A0A5G2QCL1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000008615.4\|UniProtKB=A0A9L0R7H5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000018602.5\|UniProtKB=A0A5F5XFU6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014055.1\|UniProtKB=A0A8I3NH95	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000014979.4\|UniProtKB=A0A5F8GVK6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000043996.1\|UniProtKB=A0A6I8N628	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003170.1\|UniProtKB=A0A8V0X8J3	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012647.4\|UniProtKB=G1KN45	Anolis carolinensis	LDO
XENLA\|Gene=c4a.L\|UniProtKB=Q91741	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-478881\|UniProtKB=A9JRJ9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000006961.2\|UniProtKB=H2LRP2	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000006939.2\|UniProtKB=H2LRL9	Oryzias latipes	O
DANRE\|Gene=si=dkey-8k3.2\|UniProtKB=A0A8M1Q1D0	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030131-5697\|UniProtKB=F1Q4X5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000008608.1\|UniProtKB=W5MQ17	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000019625.1\|UniProtKB=H2Y2X2	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000001054.3\|UniProtKB=F6U649	Ciona intestinalis	O
BRAFL\|Gene=LOC118403166\|UniProtKB=A0A9J7HHW2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=GeneID_373284\|UniProtKB=O44344	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892832\|UniProtKB=A0A7M7PMG7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575436\|UniProtKB=A0A7M7TG33	Strongylocentrotus purpuratus	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210666\|UniProtKB=A7SDN3	Nematostella vectensis	LDO