PANTHER Gene Information   
Gene Symbol(s): Fga
Organism: Rattus norvegicus
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Gene Name: Fibrinogen alpha chain
Gene ID: 2603
Protein ID: P06399
Persistent Id: PTN000441584
Alternate Ids:
Fga(Symbol) FIBA(Synonym)
M35601(EMBL) 204140(GI)
FIBA_RAT(UniProtKB-ID) AAA41158(EMBL-CDS)
2603(RGD)
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PANTHER Classification
PANTHER Family: FIBRINOGEN ALPHA CHAIN (PTHR47221)
PANTHER Subfamily: FIBRINOGEN ALPHA CHAIN (PTHR47221:SF3)  
PANTHER GO-slim Molecular Function: extracellular matrix structural constituent
protein-macromolecule adaptor activity
PANTHER GO-slim Biological Process: platelet aggregation
protein activation cascade
negative regulation of blood coagulation
positive regulation of cell-cell adhesion
PANTHER GO-slim Cellular Component: extracellular space
protein-containing complex
PANTHER protein class:
Pathway Categories: Plasminogen activating cascade
   Fibrin degradation products
Plasminogen activating cascade
   Fibrin
Blood coagulation
   Fibrin polymer cross-linked
Blood coagulation
   Fibrin monomer
Blood coagulation
   Fibrinogen

GO MF Complete: metal ion binding, cell adhesion molecule binding, structural molecule activity, signaling receptor binding, protein-macromolecule adaptor activity
GO BP Complete: response to X-ray, positive regulation of vasoconstriction, positive regulation of peptide hormone secretion, response to cycloheximide, blood coagulation, fibrinolysis, response to toxic substance, positive regulation of exocytosis, response to thyroid hormone, liver regeneration, response to insulin, induction of bacterial agglutination, cellular response to interleukin-6, cellular response to granulocyte colony-stimulating factor, plasminogen activation, positive regulation of smooth muscle cell migration, positive regulation of protein secretion, negative regulation of endothelial cell apoptotic process, platelet activation, platelet aggregation, cell-matrix adhesion, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, response to genistein, protein-containing complex assembly, adaptive immune response, response to growth hormone, acute-phase response, envenomation resulting in modulation of blood coagulation in another organism, protein polymerization, blood coagulation, fibrin clot formation, blood coagulation, common pathway, innate immune response, response to calcium ion, positive regulation of ERK1 and ERK2 cascade, response to estradiol, positive regulation of heterotypic cell-cell adhesion, cellular response to organic cyclic compound
GO CC Complete: extracellular space, platelet alpha granule, cell cortex, blood microparticle, external side of plasma membrane, endoplasmic reticulum, synapse, fibrinogen complex, cell surface
Reactome Pathways: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Integrin cell surface interactions, MAPK family signaling cascades, Hemostasis, Extracellular matrix organization, p130Cas linkage to MAPK signaling for integrins, MAP2K and MAPK activation, Platelet activation, signaling and aggregation, Innate Immune System, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), MAPK1/MAPK3 signaling, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Signal Transduction, RAF/MAP kinase cascade, Metabolism of proteins, Post-translational protein modification, Platelet Aggregation (Plug Formation), Regulation of TLR by endogenous ligand, Post-translational protein phosphorylation, Immune System, GRB2:SOS provides linkage to MAPK signaling for Integrins , Integrin signaling, Toll-like Receptor Cascades