PANTHER Gene Information

Gene Symbol(s):

Ace

Organism:

Drosophila melanogaster

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Gene Name:

Acetylcholinesterase

Gene ID:

FBgn0000024

Protein ID:

P07140

Persistent Id:

PTN000168517

Alternate Ids:

ACES(Synonym)	FBgn0000024(FlyBase)
NM_057605(refSeq)	Ace(Symbol)
X05893(EMBL)	Q9VFY0(AltAccession)
AAF54915(EMBL-CDS)	ACES_DROME(UniProtKB-ID)
3.1.1.7(EC)	281361699(GI)
CHEMBL2242744(ChEMBL)	41625(GeneID)
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PANTHER Classification

PANTHER Family:	ACETYLCHOLINESTERASE (PTHR43918)
PANTHER Subfamily:	ACETYLCHOLINESTERASE (PTHR43918:SF13)
PANTHER GO-slim Molecular Function:	carboxylic ester hydrolase activity
PANTHER GO-slim Biological Process:	nitrogen compound metabolic process organic substance catabolic process
PANTHER GO-slim Cellular Component:	extracellular space plasma membrane
PANTHER protein class:	esterase

Pathway Categories:

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

acetylcholinesterase

Nicotinic acetylcholine receptor signaling pathway

acetylcholinesterase

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

acetylcholinesterase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	serine hydrolase activity, protein homodimerization activity, sulfate binding, acetylcholinesterase activity, cholinesterase activity
GO BP Complete:	choline catabolic process, acetylcholine catabolic process, acetylcholine catabolic process in synaptic cleft, chemical synaptic transmission, choline metabolic process
GO CC Complete:	extracellular space, cytoplasm, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Neuronal System, Aspirin ADME, Drug ADME, Transmission across Chemical Synapses, Metabolism, Phospholipid metabolism, Synthesis of PC, Glycerophospholipid biosynthesis, Metabolism of lipids, Neurotransmitter clearance

Orthologs

ID	Organism	Type
HUMAN\|HGNC=983\|UniProtKB=P06276	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000015593.3\|UniProtKB=H2QNP1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008798.3\|UniProtKB=G3R0B5	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000003742.4\|UniProtKB=H9FXZ3	Macaca mulatta	O
MOUSE\|MGI=MGI=894278\|UniProtKB=Q03311	Mus musculus	O
RAT\|RGD=619996\|UniProtKB=A0A8J8XQI9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011139\|UniProtKB=P32749	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000000240.3\|UniProtKB=A0A9L0TAC5	Equus caballus	O
HORSE\|Gene=BCHE\|UniProtKB=P81908	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000030105\|UniProtKB=O62760	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845018401.1\|UniProtKB=A0A8I3PBA0	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000016264.4\|UniProtKB=A0A5F8G870	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000011369.4\|UniProtKB=F6U2K2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010001267.1\|UniProtKB=A0A8V0X1T8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000007719.4\|UniProtKB=G1KGY5	Anolis carolinensis	O
XENLA\|Gene=bchel.L\|UniProtKB=A0A8J1LNT8	Xenopus laevis	O
XENLA\|Gene=LOC108699002\|UniProtKB=A0A8J0TCQ1	Xenopus laevis	O
XENTR\|Ensembl=ENSXETG00000031068\|UniProtKB=A0A6I8PZR8	Xenopus tropicalis	O
XENLA\|Gene=LOC108700455\|UniProtKB=A0A1L8F4T7	Xenopus laevis	O
XENLA\|Gene=LOC108698834\|UniProtKB=A0A1L8FCT2	Xenopus laevis	O
XENTR\|Gene=LOC100494295\|UniProtKB=A0A8J0QXB0	Xenopus tropicalis	O
XENLA\|Gene=bche.L\|UniProtKB=A0A1L8GAP9	Xenopus laevis	O
XENLA\|Gene=bche.S\|UniProtKB=A0A8J1KU51	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-980117\|UniProtKB=A0A8J0QKX2	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000020161.2\|UniProtKB=H2N0U1	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000003535.1\|UniProtKB=W5M723	lepisosteus oculatus	O
GORGO\|Ensembl=ENSGGOG00000001511.3\|UniProtKB=G3QGN3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000058568.1\|UniProtKB=A0A5K1U1J8	Macaca mulatta	O
MOUSE\|MGI=MGI=87876\|UniProtKB=P21836	Mus musculus	O
RAT\|RGD=69313\|UniProtKB=P37136	Rattus norvegicus	O
BOVIN\|Gene=ACHE\|UniProtKB=P23795	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000001139.6\|UniProtKB=F1MIM4	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000030303.4\|UniProtKB=I3LU85	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000006898.4\|UniProtKB=A0A3Q2H2J6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000023546\|UniProtKB=O62763	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845000697.1\|UniProtKB=A0A8I3MIG7	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000004882.4\|UniProtKB=A0A5F8GRV2	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000050305.1\|UniProtKB=A0A6I8N2P3	Ornithorhynchus anatinus	O
CHICK\|Gene=ACHE\|UniProtKB=P36196	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010000453.1\|UniProtKB=A0A8V0X5B8	Gallus gallus	O
XENLA\|Gene=ache.L\|UniProtKB=B1WBB9	Xenopus laevis	O
XENLA\|Gene=ache.S\|UniProtKB=A0A8J0U398	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-923160\|UniProtKB=F7DYW2	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000010371.3\|UniProtKB=H2M3I8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-010906-1\|UniProtKB=Q9DDE3	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014072.1\|UniProtKB=W5N9N8	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004635.3\|UniProtKB=B1H3L8	Ciona intestinalis	O
BRAFL\|Gene=LOC118428688\|UniProtKB=A0A9J7N9G6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423133\|UniProtKB=A0A9J7LRQ0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118429404\|UniProtKB=A0A9J7N9K1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118406999\|UniProtKB=A0A9J7KAM7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418088\|UniProtKB=A0A9J7LBL1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118409683\|UniProtKB=A0A9J7KMK7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427511\|UniProtKB=A0A9J7N804	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426982\|UniProtKB=A0A9J7N766	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423462\|UniProtKB=A0A9J7LR25	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426981\|UniProtKB=A0A9J7M1A4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118429577\|UniProtKB=A0A9J7M768	Branchiostoma floridae	O
BRAFL\|Gene=LOC118428689\|UniProtKB=A0A9J7M510	Branchiostoma floridae	O
BRAFL\|Gene=LOC118408981\|UniProtKB=A0A9J7KL95	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105436985\|UniProtKB=A0A7M7NLC9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC762935\|UniProtKB=A0A7M7GHM5	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000035\|UniProtKB=P38433	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00036330\|UniProtKB=Q27459	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00105292\|UniProtKB=A0A2A6C715	Pristionchus pacificus	O
ANOGA\|EnsemblGenome=AGAP000466\|UniProtKB=Q7QFG0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC000981\|UniProtKB=D6W9E2	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_44337\|UniProtKB=E9G1H3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW012339\|UniProtKB=B7QCE8	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG120724\|UniProtKB=T1EGQ4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG76935\|UniProtKB=T1G2R7	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG31933\|UniProtKB=B3SA29	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG19242\|UniProtKB=B3RKC5	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_10908\|UniProtKB=C8VD02	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU02679\|UniProtKB=Q7SH50	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_14441\|UniProtKB=A7FA10	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_01415\|UniProtKB=Q0V3J9	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_02525\|UniProtKB=Q0V0D9	Phaeosphaeria nodorum	O
USTMA\|EnsemblGenome=UMAG_11540\|UniProtKB=A0A0D1DYF7	Ustilago maydis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_27861\|UniProtKB=F4PCH6	Batrachochytrium dendrobatidis	O