PANTHER Gene Information

Gene Symbol(s):

Chrm4

Organism:

Rattus norvegicus

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Gene Name:

Muscarinic acetylcholine receptor M4

Gene ID:

2344

Protein ID:

P08485

Persistent Id:

PTN000665591

Alternate Ids:

202666(GI)	ACM4_RAT(UniProtKB-ID)
Chrm-4(Synonym)	NM_031547(refSeq)
AAA40663(EMBL-CDS)	Chrm4(Symbol)
CHEMBL317(ChEMBL)	M16409(EMBL)
25111(GeneID)	2344(RGD)
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PANTHER Classification

PANTHER Family:	5-HYDROXYTRYPTAMINE RECEPTOR (PTHR24247)
PANTHER Subfamily:	MUSCARINIC ACETYLCHOLINE RECEPTOR M4 (PTHR24247:SF180)
PANTHER GO-slim Molecular Function:	G protein-coupled amine receptor activity neurotransmitter receptor activity
PANTHER GO-slim Biological Process:	chemical synaptic transmission adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acetylcholine receptor signaling pathway
PANTHER GO-slim Cellular Component:	dendrite plasma membrane synapse
PANTHER protein class:	G-protein coupled receptor

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Gi protein coupled receptor

Alzheimer disease-amyloid secretase pathway

Muscarinic acetylcholine receptors

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Go-protein coupled receptor

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

Muscarinic acetylcholine receptor 2 and 4

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Gq-protein coupled receptor

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein binding, guanyl-nucleotide exchange factor activity, G protein-coupled acetylcholine receptor activity, G protein-coupled serotonin receptor activity
GO BP Complete:	G protein-coupled serotonin receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, regulation of locomotion, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, chemical synaptic transmission
GO CC Complete:	presynaptic membrane, dendrite, postsynaptic membrane, sarcolemma, membrane, asymmetric synapse, neuronal cell body, synapse, glutamatergic synapse, plasma membrane, axon terminus, postsynaptic density membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Class A/1 (Rhodopsin-like receptors), Signaling by GPCR, G alpha (i) signalling events, GPCR downstream signalling, Muscarinic acetylcholine receptors, Amine ligand-binding receptors, Signal Transduction, GPCR ligand binding

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1953\|UniProtKB=P08173	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000026871.2\|UniProtKB=G3SFP9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000039412.2\|UniProtKB=G7NDH2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88399\|UniProtKB=P32211	Mus musculus	LDO
PIG\|Ensembl=ENSSSCG00000013261.5\|UniProtKB=F1SIA0	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000024780.3\|UniProtKB=M3XFA6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845028143.1\|UniProtKB=A0A8I3Q4F7	Canis lupus familiaris	LDO
CHICK\|Ensembl=ENSGALG00010023120.1\|UniProtKB=A0A8V0ZUJ1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004120.4\|UniProtKB=G1KCJ0	Anolis carolinensis	LDO
XENLA\|Gene=chrm4\|UniProtKB=P30544	Xenopus laevis	O
XENLA\|Gene=chrm4.L\|UniProtKB=A0A1L8GIV8	Xenopus laevis	O
XENLA\|Gene=chrm4.S\|UniProtKB=A0A1L8GDU2	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000046229\|UniProtKB=A0A803J2D1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000014138.2\|UniProtKB=H2MGJ1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000020679.2\|UniProtKB=H2N2D5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-090410-7\|UniProtKB=X1WE62	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-090410-6\|UniProtKB=E7F3U8	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000003264.3\|UniProtKB=F6WP04	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000008896.3\|UniProtKB=F6QF27	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000019975.1\|UniProtKB=H2Y1F3	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000007685.3\|UniProtKB=F6SIL2	Ciona intestinalis	O
BRAFL\|Gene=LOC118420244\|UniProtKB=A0A9J7LHG8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118420007\|UniProtKB=A0A9J7LIA7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118417127\|UniProtKB=A0A9J7L9B0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118417114\|UniProtKB=A0A9J7MTJ5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115918113\|UniProtKB=A0A7M7PSZ0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC589051\|UniProtKB=A0A7M7RFK5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888073\|UniProtKB=A0A7M7SVW3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115929527\|UniProtKB=A0A7M7T540	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC588917\|UniProtKB=A0A7M7NZN1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437927\|UniProtKB=A0A7M7HFB5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC577998\|UniProtKB=A0A7M7RAB8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115921849\|UniProtKB=A0A7M7NJY5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100893351\|UniProtKB=A0A7M7GIH6	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115920392\|UniProtKB=A0A7M7N723	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC591158\|UniProtKB=A0A7M7TH38	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC755178\|UniProtKB=A0A7M7LKY1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC754546\|UniProtKB=A0A7M7PRX0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001517\|UniProtKB=Q18007	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05078\|UniProtKB=A8WZ43	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00109165\|UniProtKB=A0A2A6BJJ0	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00001518\|UniProtKB=Q09388	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17450\|UniProtKB=A8XR61	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00098038\|UniProtKB=A0A2A6CDP4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0037546\|UniProtKB=Q9VHW1	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP004675\|UniProtKB=A0A1S4GLS9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034564\|UniProtKB=A0A139WNB7	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_48172\|UniProtKB=E9GAE8	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW014424\|UniProtKB=B7QLV5	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG68472\|UniProtKB=T1FZF2	helobdella robusta	O
CAEEL\|WormBase=WBGene00001519\|UniProtKB=Q9U7D5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04581\|UniProtKB=A8WXZ5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00118572\|UniProtKB=A0A2A6CGR5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0000037\|UniProtKB=P16395	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010513\|UniProtKB=Q7Q8W8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004470\|UniProtKB=D6WCK6	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW001961\|UniProtKB=B7P8V1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG132330\|UniProtKB=T1EHX8	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG5190\|UniProtKB=B3S544	Trichoplax adhaerens	O