PANTHER Gene Information

Gene Symbol(s):

leuA

Organism:

Escherichia coli

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Gene Name:

2-isopropylmalate synthase

Gene ID:

BAB96643

Protein ID:

P09151

Persistent Id:

PTN001306586

Alternate Ids:

EcoCyc:2-ISOPROPYLMALATESYN-MON(BioCyc)	146603(GI)
LEU1_ECOLI(UniProtKB-ID)	NC_000913(refSeq)
CAA38851(EMBL-CDS)	BAB96643(Ensembl)
P78044(AltAccession)	J01642(EMBL)
BAB96643(Ensembl_TRS)	2.3.3.13 {ECO:0000255\|HAMAP-Rule:MF_01025}(EC)
Alpha-isopropylmalate synthase {ECO:0000255\|HAMAP-Rule:MF_01025}(Synonym)	leuA{ECO:0000255\|HAMAP-Rule:MF_01025}(Symbol)
947465(GeneID)	BAB96643(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	HOMOCITRATE SYNTHASE-RELATED (PTHR10277)
PANTHER Subfamily:	2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED (PTHR10277:SF9)
PANTHER GO-slim Molecular Function:	acyltransferase activity
PANTHER GO-slim Biological Process:	leucine biosynthetic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	transferase

Pathway Categories:

Phenylpropionate degradation

4-Hydroxy-2-ketovalerate aldolase

Leucine biosynthesis

2-Isopropylmalate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	2-isopropylmalate synthase activity, acetyl-CoA C-acetyltransferase activity, catalytic activity, metal ion binding, manganese ion binding, transferase activity
GO BP Complete:	L-leucine biosynthetic process
GO CC Complete:	cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
BRACM\|EnsemblGenome=Bra015147\|UniProtKB=M4DF75	Brassica campestris	O
BRACM\|EnsemblGenome=Bra027712\|UniProtKB=M4EFZ9	Brassica campestris	LDO
BRACM\|EnsemblGenome=Bra002624\|UniProtKB=M4CEJ3	Brassica campestris	O
BRACM\|EnsemblGenome=Bra015365\|UniProtKB=M4DFU2	Brassica campestris	O
NITMS\|EnsemblGenome=Nmar_1293\|UniProtKB=A9A1L0	Nitrosopumilus maritimus	O
NITMS\|EnsemblGenome=Nmar_0140\|UniProtKB=A9A1R9	Nitrosopumilus maritimus	O
NITMS\|EnsemblGenome=Nmar_1070\|UniProtKB=A9A4I8	Nitrosopumilus maritimus	LDO
KORCO\|EnsemblGenome=Kcr_0588\|UniProtKB=B1L4G2	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_0973\|UniProtKB=B1L5J0	Korarchaeum cryptofilum	LDO
KORCO\|EnsemblGenome=Kcr_0193\|UniProtKB=B1L3C4	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0977\|UniProtKB=Q97ZE0	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1986\|UniProtKB=Q8ZW39	Pyrobaculum aerophilum	O
SACS2\|EnsemblGenome=SSO2407\|UniProtKB=Q97W36	Sulfolobus solfataricus	LDO
PYRAE\|EnsemblGenome=PAE1993\|UniProtKB=Q8ZW35	Pyrobaculum aerophilum	LDO
METAC\|EnsemblGenome=MA_3342\|UniProtKB=Q8TKQ6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_4615\|UniProtKB=Q8THA5	Methanosarcina acetivorans	LDO
METJA\|EnsemblGenome=MJ_0503\|UniProtKB=Q57926	Methanocaldococcus jannaschii	O
METJA\|EnsemblGenome=MJ_1195\|UniProtKB=Q58595	Methanocaldococcus jannaschii	LDO
THEKO\|EnsemblGenome=TK0283\|UniProtKB=Q5JFV5	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_1351\|UniProtKB=A9W9U3	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCP1.301\|UniProtKB=Q99PZ1	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3469c\|UniProtKB=O06334	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3534c\|UniProtKB=P9WMK5	Mycobacterium tuberculosis	O
CHLAA\|EnsemblGenome=Caur_0166\|UniProtKB=A9WC27	Chloroflexus aurantiacus	LDO
STAA8\|EnsemblGenome=SAOUHSC_00914\|UniProtKB=Q2FZS6	Staphylococcus aureus	O
STAA8\|EnsemblGenome=SAOUHSC_02285\|UniProtKB=Q2FWK3	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAD00065\|UniProtKB=Q8Y5R9	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_28280\|UniProtKB=P94565	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_1400\|UniProtKB=Q81G12	Bacillus cereus	LDO
THEMA\|EnsemblGenome=TM_0553\|UniProtKB=Q9WZ23	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_1482\|UniProtKB=Q9RUA9	Deinococcus radiodurans	LDO
GLOVI\|EnsemblGenome=BAC90231\|UniProtKB=Q7NI93	Gloeobacter violaceus	LDO
SYNY3\|EnsemblGenome=BAA10079\|UniProtKB=P48576	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_0469\|UniProtKB=Q8F8T4	Leptospira interrogans	O
LEPIN\|EnsemblGenome=LA_2202\|UniProtKB=Q8F445	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_1861\|UniProtKB=Q8A6L6	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB12756\|UniProtKB=Q7UI51	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_2090\|UniProtKB=O67862	Aquifex aeolicus	LDO
THEYD\|EnsemblGenome=THEYE_A0650\|UniProtKB=B5YJS7	Thermodesulfovibrio yellowstonii	LDO
DICTD\|EnsemblGenome=Dtur_1190\|UniProtKB=B8E2W9	Dictyoglomus turgidum	LDO
NEIMB\|EnsemblGenome=NMB1070\|UniProtKB=Q9JZG1	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU1906\|UniProtKB=Q74BX2	Geobacter sulfurreducens	LDO
BRADU\|EnsemblGenome=BAC51700\|UniProtKB=Q89GB0	Bradyrhizobium diazoefficiens	LDO
HAEIN\|EnsemblGenome=HI_0986\|UniProtKB=P43861	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_4236\|UniProtKB=Q8E9N2	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_2490\|UniProtKB=Q9KP83	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC3327\|UniProtKB=P58901	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA1217\|UniProtKB=Q9I4C1	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM0113\|UniProtKB=P15875	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_3649\|UniProtKB=Q8ZIG8	Yersinia pestis	LDO