PANTHER Gene Information   
Gene Symbol(s): Gpc3
Organism: Rattus norvegicus
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Gene Name: Glypican-3
Gene ID: 2725
Protein ID: P13265
Persistent Id: PTN000850525
Alternate Ids:
Gpc3(Symbol) 2725(RGD)
BC085756(EMBL) 55249689(GI)
AAH85756(EMBL-CDS) GPC3(Synonym)
NM_012774(refSeq) Q5U326(AltAccession)
25236(GeneID) GPC3_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: GLYPICAN (PTHR10822)
PANTHER Subfamily: GLYPICAN-3 (PTHR10822:SF4)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: regulation of protein localization to membrane
positive regulation of canonical Wnt signaling pathway
cell migration
PANTHER GO-slim Cellular Component: extracellular region
cell surface
plasma membrane
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: No pathway information available
GO MF Complete: peptidyl-dipeptidase inhibitor activity
GO BP Complete: negative regulation of growth, negative regulation of cell population proliferation, positive regulation of endocytosis, anterior/posterior axis specification, epithelial cell proliferation, kidney development, regulation of canonical Wnt signaling pathway, canonical Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, cell proliferation involved in metanephros development, cell migration, embryonic hindlimb morphogenesis, lung development, regulation of protein localization to membrane, regulation of non-canonical Wnt signaling pathway, biological_process, bone mineralization, positive regulation of Wnt signaling pathway, planar cell polarity pathway, body morphogenesis, coronary vasculature development, positive regulation of canonical Wnt signaling pathway, smoothened signaling pathway, positive regulation of protein catabolic process, positive regulation of D-glucose import, regulation of growth, negative regulation of smoothened signaling pathway, animal organ morphogenesis, mesonephric duct morphogenesis, osteoclast differentiation, negative regulation of canonical Wnt signaling pathway, positive regulation of BMP signaling pathway, response to bacterium, cell migration involved in gastrulation, branching involved in ureteric bud morphogenesis, positive regulation of smoothened signaling pathway, negative regulation of epithelial cell proliferation, cell proliferation involved in kidney development, mesenchymal cell proliferation involved in ureteric bud development
GO CC Complete: side of membrane, collagen-containing extracellular matrix, plasma membrane, lysosome, cell surface
Reactome Pathways: A tetrasaccharide linker sequence is required for GAG synthesis, Glycosaminoglycan metabolism, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Metabolism of carbohydrates, Retinoid metabolism and transport, Metabolism of proteins, Post-translational protein modification, Heparan sulfate/heparin (HS-GAG) metabolism, Visual phototransduction, Metabolism, HS-GAG biosynthesis, Post-translational protein phosphorylation, Chondroitin sulfate/dermatan sulfate metabolism, Metabolism of vitamins and cofactors, HS-GAG degradation, Sensory Perception, Metabolism of fat-soluble vitamins