PANTHER Gene Information   
Gene Symbol(s): ADRB3
Organism: Homo sapiens
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Gene Name: Beta-3 adrenergic receptor
Gene ID: HGNC:288
Protein ID: P13945
Enhancers: View enhancers for HUMAN|HGNC=288|UniProtKB=P13945
Genetic Variant Annotation: Annoq
Persistent Id: PTN002517630
Alternate Ids:
ENSG00000188778(Ensembl) 1666376(GI)
ADRB3(Symbol) CAA50141(EMBL-CDS)
M29932(EMBL) ENST00000345060(Ensembl_TRS)
CHEMBL246(ChEMBL) Beta-3 adrenoreceptor(Synonym)
ENSP00000343782(Ensembl_PRO) 109691(MIM)
155(GeneID) HGNC:288(HGNC)
Q4JFT4(AltAccession) ADRB3_HUMAN(UniProtKB-ID)
NM_000025(refSeq)
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PANTHER Classification
PANTHER Family: ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR (PTHR24248)
PANTHER Subfamily: BETA-3 ADRENERGIC RECEPTOR (PTHR24248:SF3)  
PANTHER GO-slim Molecular Function: G protein-coupled amine receptor activity
hormone binding
PANTHER GO-slim Biological Process: regulation of systemic arterial blood pressure
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of MAPK cascade
regulation of anatomical structure size
negative regulation of blood pressure
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: G-protein coupled receptor
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Gs-protein coupled receptor
Beta3 adrenergic receptor signaling pathway
   Beta3 adrenergic receptor
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: epinephrine binding, protein binding, protein homodimerization activity, beta-adrenergic receptor activity, beta3-adrenergic receptor activity, norepinephrine binding, beta-3 adrenergic receptor binding
GO BP Complete: negative regulation of multicellular organism growth, generation of precursor metabolites and energy, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, energy reserve metabolic process, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, diet induced thermogenesis, norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure, eating behavior, carbohydrate metabolic process, response to cold, heat generation, brown fat cell differentiation, adenylate cyclase-activating adrenergic receptor signaling pathway, positive regulation of cold-induced thermogenesis
GO CC Complete: receptor complex, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signal Transduction, GPCR downstream signalling, G alpha (s) signalling events, Adrenoceptors, Amine ligand-binding receptors, Signaling by GPCR, GPCR ligand binding, Class A/1 (Rhodopsin-like receptors)

Orthologs