PANTHER Gene Information   
Gene Symbol(s): ARRB1
Organism: Bos taurus
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Gene Name: Beta-arrestin-1
Gene ID: ENSBTAG00000020485
Protein ID: P17870
Persistent Id: PTN007538479
Alternate Ids:
ARRB1_BOVIN(UniProtKB-ID) 15987988(GI)
ARRB1(Synonym) ARRB1(Symbol)
M33601(EMBL) AAA30387(EMBL-CDS)
ENSBTAG00000020485(Ensembl) 281637(GeneID)
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PANTHER Classification
PANTHER Family: ARRESTIN (PTHR11792)
PANTHER Subfamily: BETA-ARRESTIN-1 (PTHR11792:SF22)  
PANTHER GO-slim Molecular Function: G protein-coupled receptor binding
PANTHER GO-slim Biological Process: receptor internalization
regulation of G protein-coupled receptor signaling pathway
negative regulation of signal transduction
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   beta-arrestin
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
   beta-arrestin 1
Inflammation mediated by chemokine and cytokine signaling pathway
   beta-arrestin
Wnt signaling pathway
   beta-arrestin
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: phosphatidylinositol-3,4,5-trisphosphate binding, clathrin heavy chain binding, G protein-coupled receptor binding, protein binding, acetylcholine receptor binding, inositol hexakisphosphate binding, small molecule binding, clathrin binding, AP-2 adaptor complex binding, molecular adaptor activity
GO BP Complete: clathrin-dependent endocytosis, desensitization of G protein-coupled receptor signaling pathway, positive regulation of receptor internalization, signal transduction, positive regulation of protein phosphorylation, protein transport, positive regulation of ERK1 and ERK2 cascade, G protein-coupled receptor internalization, visual perception, negative regulation of Notch signaling pathway, receptor internalization, ubiquitin-dependent protein catabolic process
GO CC Complete: nucleus, cytoplasm, clathrin coat of coated pit, cytosol, cytoplasmic vesicle, pseudopodium, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Clathrin-mediated endocytosis, Ub-specific processing proteases, Post-translational protein modification, Cargo recognition for clathrin-mediated endocytosis, Platelet activation, signaling and aggregation, Signal Transduction, Activation of SMO, Hemostasis, Vesicle-mediated transport, MAP2K and MAPK activation, RAF/MAP kinase cascade, Thrombin signalling through proteinase activated receptors (PARs), trans-Golgi Network Vesicle Budding, Metabolism of proteins, Membrane Trafficking, Deubiquitination, MAPK family signaling cascades, GPCR downstream signalling, Signaling by GPCR, MAPK1/MAPK3 signaling, Hedgehog 'on' state, G alpha (s) signalling events, Golgi Associated Vesicle Biogenesis, Signaling by Hedgehog, Lysosome Vesicle Biogenesis

Orthologs