PANTHER Gene Information

Gene Symbol(s):

Hsd3b2

Organism:

Mus musculus

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Gene Name:

3 beta-hydroxysteroid dehydrogenase_Delta 5--4-isomerase type 2

Gene ID:

MGI:96234

Protein ID:

P26149

Persistent Id:

PTN000041434

Alternate Ids:

3BHS2_MOUSE(UniProtKB-ID)	MGI:96234(MGI)
568921875(GI)	ENSMUSP00000102636(Ensembl_PRO)
AAH26757(EMBL-CDS)	ENSMUSG00000063730(Ensembl)
M75886(EMBL)	1.1.1.145 {ECO:0000250\|UniProtKB:P26439}(EC)
Hsd3b2{ECO:0000312\|MGI:MGI:96234}(Symbol)	ENSMUST00000107021(Ensembl_TRS)
Q8R0J6(AltAccession)	3BHS2(Synonym)
15493(GeneID)	NP_694873(refSeq)
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PANTHER Classification

PANTHER Family:	NAD DEPENDENT EPIMERASE/DEHYDRATASE (PTHR10366)
PANTHER Subfamily:	3 BETA-HYDROXYSTEROID DEHYDROGENASE_DELTA 5--4-ISOMERASE TYPE 1 (PTHR10366:SF364)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydratase

Pathway Categories:

Androgen/estrogene/progesterone biosynthesis

3beta-Hydroxysteroid dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, catalytic activity, steroid delta-isomerase activity, oxidoreductase activity, cholesterol dehydrogenase activity, isomerase activity
GO BP Complete:	response to corticosterone, androgen biosynthetic process, lipid metabolic process, metabolic process, hippocampus development, steroid biosynthetic process, C21-steroid hormone metabolic process, C21-steroid hormone biosynthetic process, negative regulation of iron ion transport
GO CC Complete:	mitochondrial intermembrane space, intercellular bridge, cytoplasm, intracellular membrane-bounded organelle, mitochondrion, membrane, endoplasmic reticulum, nucleolus, mitochondrial inner membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Mineralocorticoid biosynthesis, Metabolism of steroid hormones, Glucocorticoid biosynthesis, Androgen biosynthesis, Metabolism, Metabolism of steroids, Metabolism of lipids

Orthologs

ID	Organism	Type
HUMAN\|HGNC=5217\|UniProtKB=P14060	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000042979.1\|UniProtKB=A0A2I3THQ2	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000024031.4\|UniProtKB=A0A2J8JUJ9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000003349.3\|UniProtKB=G3QLD6	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000047765.2\|UniProtKB=F7HEJ6	Macaca mulatta	O
PANTR\|Ensembl=ENSPTRG00000052660.1\|UniProtKB=A0A2I3TJ30	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000041320.1\|UniProtKB=A0A2I2YBN8	Gorilla gorilla gorilla	O
HUMAN\|HGNC=5218\|UniProtKB=P26439	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000048520.1\|UniProtKB=A0A2I3T731	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000047558.1\|UniProtKB=A0A2I3SN04	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000023445.6\|UniProtKB=A0A2J8JUI4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000041410.1\|UniProtKB=G3QLD9	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000016568\|UniProtKB=P27365	Macaca mulatta	O
RAT\|RGD=67377\|UniProtKB=Q62878	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000006769\|UniProtKB=P14893	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000006719\|UniProtKB=Q9N119	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000014483\|UniProtKB=O46516	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000025160.4\|UniProtKB=G8GE25	Felis catus	O
CANLF\|Ensembl=ENSCAFG00000010039\|UniProtKB=Q5IFP1	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000040590.1\|UniProtKB=F7GG98	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000011957.3\|UniProtKB=K7E974	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000008094.3\|UniProtKB=H9GDG8	Anolis carolinensis	O
XENLA\|Gene=hsd3b1.L\|UniProtKB=Q3KPY4	Xenopus laevis	O
XENTR\|Gene=LOC100490622\|UniProtKB=A0A8J1J359	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000008590.2\|UniProtKB=H2LXC2	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030828-2\|UniProtKB=Q7ZZC3	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-081105-30\|UniProtKB=F1QSA2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010975.1\|UniProtKB=W5MYK3	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000011736.2\|UniProtKB=F6TX70	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000011737.2\|UniProtKB=F6TX66	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_245803\|UniProtKB=C3Y0G8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427492\|UniProtKB=A0A9J7N859	Branchiostoma floridae	O
BRAFL\|Gene=LOC118428002\|UniProtKB=A0A9J7M3X4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118426116\|UniProtKB=A0A9J7N481	Branchiostoma floridae	O
BRAFL\|Gene=LOC118404685\|UniProtKB=A0A9J7HI08	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427590\|UniProtKB=A0A9J7M2F6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592634\|UniProtKB=A0A7M7HK30	Strongylocentrotus purpuratus	O
DROME\|FlyBase=FBgn0036698\|UniProtKB=Q9VVE3	Drosophila melanogaster	O
IXOSC\|EnsemblGenome=ISCW007167\|UniProtKB=B7PVZ1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007164\|UniProtKB=B7PVZ0	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW018715\|UniProtKB=B7PKR2	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG89375\|UniProtKB=T1G7C5	helobdella robusta	O
CHLRE\|EnsemblGenome=CHLRE_10g442200v5\|UniProtKB=A8II92	Chlamydomonas reinhardtii	O
GLOVI\|Gene=Q7NDS6_GLOVI\|UniProtKB=Q7NDS6	Gloeobacter violaceus	O
RHOBA\|EnsemblGenome=RB8551\|UniProtKB=Q7UFH4	Rhodopirellula baltica	O
GLOVI\|Gene=Q7NJT5_GLOVI\|UniProtKB=Q7NJT5	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA17239\|UniProtKB=P73212	Synechocystis	O
GEOSL\|EnsemblGenome=GSU0687\|UniProtKB=Q74FC2	Geobacter sulfurreducens	O