PANTHER Gene Information

Gene Symbol(s):

SLC6A12

Organism:

Canis lupus familiaris

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Gene Name:

Sodium- and chloride-dependent betaine transporter

Gene ID:

ENSCAFG00805031392

Protein ID:

P27799

Persistent Id:

PTN000177959

Alternate Ids:

404013(GeneID)	ENSCAFP00845037173(Ensembl_PRO)
XM_005636684(refSeq)	545545094(GI)
S6A12_CANLF(UniProtKB-ID)	ENSCAFG00805031392(Ensembl)
BAA22547(EMBL-CDS)	M80403(EMBL)
SLC6A12(Symbol)	ENSCAFT00040046662(Ensembl_TRS)
Na(+)/Cl(-) betaine/GABA transporter(Synonym)
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PANTHER Classification

PANTHER Family:	SODIUM/CHLORIDE DEPENDENT TRANSPORTER (PTHR11616)
PANTHER Subfamily:	SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER (PTHR11616:SF118)
PANTHER GO-slim Molecular Function:	amino acid:sodium symporter activity secondary active monocarboxylate transmembrane transporter activity chloride transmembrane transporter activity
PANTHER GO-slim Biological Process:	sodium ion transmembrane transport amino acid transport
PANTHER GO-slim Cellular Component:	cell projection plasma membrane
PANTHER protein class:	primary active transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	gamma-aminobutyric acid:sodium:chloride symporter activity
GO BP Complete:	neurotransmitter transport, glycine betaine transport, monocarboxylic acid transport, sodium ion transmembrane transport, gamma-aminobutyric acid transport, amino acid transport
GO CC Complete:	basolateral plasma membrane, cell projection, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Transport of inorganic cations/anions and amino acids/oligopeptides, Metabolism of amino acids and derivatives, Transport of bile salts and organic acids, metal ions and amine compounds, Neuronal System, Creatine metabolism, SLC-mediated transmembrane transport, Reuptake of GABA, Transport of small molecules, GABA synthesis, release, reuptake and degradation, Na+/Cl- dependent neurotransmitter transporters, Transmission across Chemical Synapses, Metabolism, Amino acid transport across the plasma membrane, Neurotransmitter release cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11045\|UniProtKB=P48065	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004504.5\|UniProtKB=A0A2J8ILY3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007497.3\|UniProtKB=G3QX15	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000061421.1\|UniProtKB=F7HP51	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95628\|UniProtKB=P31651	Mus musculus	LDO
RAT\|RGD=620255\|UniProtKB=P48056	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000038415.3\|UniProtKB=A0A3Q1LJ84	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000000749.5\|UniProtKB=A0A287AYA7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000036638.3\|UniProtKB=A0A3Q2GUI3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014339.6\|UniProtKB=M3X4J5	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000018378.4\|UniProtKB=F6QVR2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010941.3\|UniProtKB=A0A6I8MYS4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015929.1\|UniProtKB=E1BQT4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000025590.3\|UniProtKB=G1KY99	Anolis carolinensis	LDO
XENLA\|Gene=LOC108704574\|UniProtKB=A0A8J0U7Q7	Xenopus laevis	O
XENLA\|Gene=LOC108712579\|UniProtKB=A0A8J0UVF6	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000049053\|UniProtKB=A0A803K5R7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000028327.1\|UniProtKB=A0A3B3IBM5	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-061215-110\|UniProtKB=Q1LVI7	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050420-315\|UniProtKB=Q1LVJ1	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050420-179\|UniProtKB=Q1LVI6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050419-161\|UniProtKB=Q1LVI9	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-050420-178\|UniProtKB=Q1LVJ0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000014677.1\|UniProtKB=W5NBR8	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000004948.2\|UniProtKB=A0A3B3HKX2	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000020091.2\|UniProtKB=H2N0L7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030616-628\|UniProtKB=F1Q5E6	Danio rerio	O
DANRE\|Gene=slc6a13\|UniProtKB=A0A8M2BDD5	Danio rerio	O
DANRE\|Gene=slc6a13l\|UniProtKB=A0A8M2BDC6	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030616-629\|UniProtKB=Q801U6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012488.1\|UniProtKB=W5N434	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000019043.2\|UniProtKB=H2MXS4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000001818.2\|UniProtKB=H2L8T4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000001859.2\|UniProtKB=H2L8Y3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-3729\|UniProtKB=A5D8R6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012363.1\|UniProtKB=W5N3M2	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000014795.2\|UniProtKB=H2MIR6	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000016855.1\|UniProtKB=W5NJM7	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000030259.1\|UniProtKB=A0A3B3HMK0	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000012601.1\|UniProtKB=W5N4G3	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000002318.2\|UniProtKB=H2LAG6	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000011499.2\|UniProtKB=H2M7F1	Oryzias latipes	O
DANRE\|Gene=LOC100332592\|UniProtKB=A0A8M1REL7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000016994.1\|UniProtKB=W5NK54	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000004671.3\|UniProtKB=F6QSQ2	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000000123.3\|UniProtKB=F6SIE8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000006841.3\|UniProtKB=F7AFY1	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000005514.3\|UniProtKB=F6YPI9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000003845.3\|UniProtKB=F6YPZ5	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000008543.3\|UniProtKB=F6XQ30	Ciona intestinalis	O
BRAFL\|Gene=LOC118415466\|UniProtKB=A0A9J7L4L6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118415465\|UniProtKB=A0A9J7L4V2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118415467\|UniProtKB=A0A9J7L5Y6	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115919833\|UniProtKB=A0A7M7N4X0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592574\|UniProtKB=A0A7M7HMQ1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115926076\|UniProtKB=A0A7M7T161	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC757159\|UniProtKB=A0A7M7N2B0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888394\|UniProtKB=A0A7M7N3R5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575802\|UniProtKB=A0A7M7N1D2	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592669\|UniProtKB=A0A7M7N237	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115926051\|UniProtKB=A0A7M7P6P4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC764578\|UniProtKB=A0A7M7MX21	Strongylocentrotus purpuratus	O
IXOSC\|EnsemblGenome=ISCW010973\|UniProtKB=B7Q9C6	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW020974\|UniProtKB=B7Q8Z6	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW016408\|UniProtKB=B7P1X3	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW010971\|UniProtKB=B7Q9C4	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g247614\|UniProtKB=A7SVA2	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG54650\|UniProtKB=B3RSM1	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_08966\|UniProtKB=C8VL87	Emericella nidulans	O
PHANO\|EnsemblGenome=SNOG_05834\|UniProtKB=Q0UQY0	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_04273\|UniProtKB=Q0UVE1	Phaeosphaeria nodorum	O
PLAF7\|EnsemblGenome=PF3D7_0209600\|UniProtKB=O96181	Plasmodium falciparum	O
PLAF7\|EnsemblGenome=PF3D7_1132500\|UniProtKB=Q8II40	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00003373001\|UniProtKB=A0DZD7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003369001\|UniProtKB=A0DZD3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00005033001\|UniProtKB=A0BJE3	Paramecium tetraurelia	O
THEKO\|EnsemblGenome=TK1432\|UniProtKB=Q5JDK2	Thermococcus kodakaraensis	O
LEPIN\|EnsemblGenome=LA_1877\|UniProtKB=Q8F511	Leptospira interrogans	O
AQUAE\|EnsemblGenome=aq_2077\|UniProtKB=O67854	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0808\|UniProtKB=B5YK84	Thermodesulfovibrio yellowstonii	O