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Gene Symbol(s):
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PIK3CA
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| Organism: |
Bos taurus |
| View Gene in Tree |
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| Gene Name: |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
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| Gene ID: |
ENSBTAG00000009232
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| Protein ID: |
P32871
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| Persistent Id: |
PTN000005767 |
| Alternate Ids: |
| NP_776999(refSeq) |
2.7.1.137 {ECO:0000269|PubMed:1322797, ECO:0000269|PubMed:14729945, ECO:0000305|PubMed:15178440}(EC) |
| ENSBTAP00000068953(Ensembl_PRO) |
282306(GeneID) |
| PtdIns-3-kinase subunit p110-alpha(Synonym) |
CHEMBL2498(ChEMBL) |
| PIK3CA(Symbol) |
PK3CA_BOVIN(UniProtKB-ID) |
| AAA30698(EMBL-CDS) |
ENSBTAT00000012168(Ensembl_TRS) |
| ENSBTAG00000009232(Ensembl) |
M93252(EMBL) |
549269902(GI) |
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Show All
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| GO MF Complete: |
protein kinase activator activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, 3-phosphoinositide-dependent protein kinase activity, protein binding, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, insulin receptor substrate binding, Rho-dependent protein serine/threonine kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, histone H3T11 kinase activity, 1-phosphatidylinositol-3-kinase activity, histone H3T6 kinase activity
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| GO BP Complete: |
regulation of multicellular organism growth, insulin receptor signaling pathway, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol phosphate biosynthetic process, glucose metabolic process, negative regulation of neuron apoptotic process, phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of anoikis, angiogenesis, cellular response to glucose stimulus, liver development, energy homeostasis, response to muscle stretch, cell migration, autosome genomic imprinting, positive regulation of lamellipodium assembly, negative regulation of fibroblast apoptotic process, cardiac muscle cell contraction, positive regulation of protein localization to membrane, vascular endothelial growth factor signaling pathway, insulin-like growth factor receptor signaling pathway, regulation of cellular respiration, adipose tissue development, negative regulation of actin filament depolymerization, cellular response to hydrostatic pressure, phosphatidylinositol-mediated signaling, phagocytosis, actin cytoskeleton organization, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, relaxation of cardiac muscle
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| GO CC Complete: |
phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IB, perinuclear region of cytoplasm, cytoplasm, intercalated disc, plasma membrane, lamellipodium
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| Reactome Pathways: |
CD28 co-stimulation, Cytokine Signaling in Immune system, Interleukin-3, Interleukin-5 and GM-CSF signaling, Signaling by Interleukins, Adaptive Immune System, Role of phospholipids in phagocytosis, CD28 dependent PI3K/Akt signaling, PI3K Cascade, Intracellular signaling by second messengers, Downstream signaling of activated FGFR4, PI3K events in ERBB2 signaling, Platelet activation, signaling and aggregation, Signal Transduction, Signaling by ERBB2, Signaling by ALK, TCR signaling, Metabolism, Innate Immune System, GAB1 signalosome, Signaling by PDGF, Hemostasis, Downstream signaling of activated FGFR1, PI-3K cascade:FGFR4, PI-3K cascade:FGFR1, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Negative regulation of the PI3K/AKT network, RAF/MAP kinase cascade, Fcgamma receptor (FCGR) dependent phagocytosis, PIP3 activates AKT signaling, Signaling by Erythropoietin, PI3K/AKT activation, RHO GTPase cycle, Interleukin receptor SHC signaling, RAC2 GTPase cycle, Immune System, PI Metabolism, Signaling by MET, Insulin receptor signalling cascade, Phospholipid metabolism, Signaling by Insulin receptor, Role of LAT2/NTAL/LAB on calcium mobilization, Developmental Biology, GPCR downstream signalling, PI-3K cascade:FGFR2, Signaling by SCF-KIT, Signaling by NTRK1 (TRKA), Extra-nuclear estrogen signaling, Signaling by ERBB4, Downstream signaling of activated FGFR2, MAPK1/MAPK3 signaling, VEGFA-VEGFR2 Pathway, Signaling by FGFR, Signaling by Rho GTPases, Synthesis of PIPs at the plasma membrane, Regulation of signaling by CBL, Costimulation by the CD28 family, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, RET signaling, PI3K events in ERBB4 signaling, Interleukin-2 family signaling, Signaling by FGFR1, Signaling by NTRKs, Signaling by FGFR2, Downstream TCR signaling, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by FGFR3, GPVI-mediated activation cascade, Signaling by FGFR4, IRS-related events triggered by IGF1R, IGF1R signaling cascade, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Axon guidance, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Tie2 Signaling, RAC1 GTPase cycle, Signaling by EGFR, DAP12 interactions, FLT3 Signaling, Metabolism of lipids, DAP12 signaling, Cell surface interactions at the vascular wall, MAPK family signaling cascades, Downstream signaling of activated FGFR3, MET activates PI3K/AKT signaling, IRS-mediated signalling, Downstream signal transduction, Signaling by GPCR, ESR-mediated signaling, PI-3K cascade:FGFR3, Fc epsilon receptor (FCERI) signaling, Signaling by VEGF, G alpha (q) signalling events, Nervous system development
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