PANTHER Gene Information

Gene Symbol(s):

Uch

Organism:

Drosophila melanogaster

View Gene in Tree


Tree	Reduced Tree

Gene Name:

Ubiquitin carboxyl-terminal hydrolase

Gene ID:

FBgn0010288

Protein ID:

P35122

Persistent Id:

PTN000063454

Alternate Ids:

FBgn0010288(Ensembl)	320544423(GI)
UCHL_DROME(UniProtKB-ID)	AAF51291(EMBL-CDS)
NP_476940(refSeq)	Q4PIX7(AltAccession)
FBgn0010288(FlyBase)	33397(GeneID)
FBpp0292511(Ensembl_PRO)	3.4.19.12(EC)
Uch(Symbol)	ubc-D(Synonym)
AE014134(EMBL)	FBtr0077844(Ensembl_TRS)
Show All

PANTHER Classification

PANTHER Family:	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (PTHR10589)
PANTHER Subfamily:	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE (PTHR10589:SF17)
PANTHER GO-slim Molecular Function:	cysteine-type deubiquitinase activity
PANTHER GO-slim Biological Process:	protein deubiquitination
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	cysteine protease

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	cysteine-type deubiquitinase activity
GO BP Complete:	protein catabolic process, positive regulation of glycolytic process, ubiquitin-dependent protein catabolic process
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Protein ubiquitination, UCH proteinases, Deubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Neddylation, Metabolism of proteins, Post-translational protein modification

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12513\|UniProtKB=P09936	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000016009.5\|UniProtKB=K7C9R6	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000008809.3\|UniProtKB=G3R0C8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000013071.4\|UniProtKB=A0A1D5RBB0	Macaca mulatta	O
MOUSE\|MGI=MGI=103149\|UniProtKB=Q9R0P9	Mus musculus	O
RAT\|RGD=3928\|UniProtKB=Q00981	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000005078\|UniProtKB=P23356	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000022945\|UniProtKB=Q6SEG5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000018254.4\|UniProtKB=F7DKB2	Equus caballus	O
HORSE\|Gene=UCHL1\|UniProtKB=Q9GM50	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000025457.4\|UniProtKB=A0A2I2U743	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845003870.1\|UniProtKB=A0A8I3MS47	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000020568\|UniProtKB=P50103	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000050393.1\|UniProtKB=A0A6I8P3R5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010015596.1\|UniProtKB=A0A8V0YUG5	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000011963.4\|UniProtKB=G1KLS5	Anolis carolinensis	O
XENLA\|Gene=uchl1.S\|UniProtKB=Q3B8B3	Xenopus laevis	O
XENLA\|Gene=uchl1.L\|UniProtKB=A0A1L8HTQ5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1000432\|UniProtKB=F6ZAI1	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000007844.2\|UniProtKB=A0A3B3H6U7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-3844\|UniProtKB=Q7ZTI4	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012930.1\|UniProtKB=W5N5M1	lepisosteus oculatus	O
HUMAN\|HGNC=12515\|UniProtKB=P15374	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000015683.3\|UniProtKB=G3SEB1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000003560.4\|UniProtKB=I0FMS4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1890440\|UniProtKB=P58321	Mus musculus	O
MOUSE\|MGI=MGI=1355274\|UniProtKB=Q9JKB1	Mus musculus	LDO
RAT\|RGD=150340882\|UniProtKB=A0A8I5Y6Y9	Rattus norvegicus	O
RAT\|RGD=1561196\|UniProtKB=Q91Y78	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000008024\|UniProtKB=Q2TBG8	Bos taurus	LDO
PIG\|Gene=UCHL3\|UniProtKB=Q06AB3	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000009466.5\|UniProtKB=A0A5G2QNC6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024190.4\|UniProtKB=A0A9L0S5E2	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000003783.3\|UniProtKB=A0A9R1SJZ0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000027839.4\|UniProtKB=A0A337S3N7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024890.1\|UniProtKB=A0A8I3Q5H6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000000990.4\|UniProtKB=A0A5F8HB82	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000006493.4\|UniProtKB=A0A6I8NE40	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010000810.1\|UniProtKB=A0A8V0X8W4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002035.4\|UniProtKB=A0A803SRI2	Anolis carolinensis	LDO
XENLA\|Gene=uchl3.S\|UniProtKB=A0A1L8H960	Xenopus laevis	O
XENLA\|Gene=uchl3.L\|UniProtKB=Q5XHE2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-980858\|UniProtKB=Q28GY5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011347.2\|UniProtKB=H2M6W4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050522-158\|UniProtKB=Q504C0	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011397.1\|UniProtKB=W5N056	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000000673.3\|UniProtKB=F6QSC7	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118418982\|UniProtKB=A0A9J7LF47	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100889551\|UniProtKB=A0A7M7NKE2	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006722\|UniProtKB=Q8MNY0	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006723\|UniProtKB=Q965V9	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG18953\|UniProtKB=A8XUF3	Caenorhabditis briggsae	LDO
CAEEL\|WormBase=WBGene00006721\|UniProtKB=Q9UAV3	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038250\|UniProtKB=A8XUF4	Caenorhabditis briggsae	O
ANOGA\|EnsemblGenome=AGAP012113\|UniProtKB=Q7PZW0	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC007923\|UniProtKB=D2A345	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC003809\|UniProtKB=D6WF38	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_188571\|UniProtKB=E9GVV1	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG185187\|UniProtKB=T1FMH5	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g107252\|UniProtKB=A7S784	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG56125\|UniProtKB=B3RX91	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_35021\|UniProtKB=A9UV03	Monosiga brevicollis	LDO
YEAST\|SGD=S000003860\|UniProtKB=P35127	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGL314C\|UniProtKB=Q751L5	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000198739\|UniProtKB=A0A1D8PDR9	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F15697g\|UniProtKB=Q6C1J7	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_11218\|UniProtKB=C8VQB4	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G11950\|UniProtKB=Q4WVF8	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_13873\|UniProtKB=A7F8E2	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_01947\|UniProtKB=Q0V217	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_07491\|UniProtKB=Q5AW39	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G05590\|UniProtKB=Q4WHF5	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU06372\|UniProtKB=V5IMH7	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_13763\|UniProtKB=A7F833	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_00064\|UniProtKB=Q0V7F0	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_14045\|UniProtKB=Q0U2I8	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC27F1.03c\|UniProtKB=Q10171	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00795\|UniProtKB=B6JWL7	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNA01690\|UniProtKB=Q5KPS7	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_01905\|UniProtKB=A0A0D1E8M1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_00062\|UniProtKB=E3JQ23	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_18748\|UniProtKB=F4NXC2	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_152100\|UniProtKB=C4LSP8	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0282007\|UniProtKB=Q54T48	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_146855\|UniProtKB=F0Z727	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_25_0190\|UniProtKB=Q4QA77	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.03.0890\|UniProtKB=Q387M6	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_455660\|UniProtKB=A2G055	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_204450\|UniProtKB=A2FJ39	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1460400\|UniProtKB=Q8IKM8	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00036561001\|UniProtKB=A0CAG4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00001443001\|UniProtKB=A0CWS3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035384001\|UniProtKB=A0C638	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_263931\|UniProtKB=B8CAN7	Thalassiosira pseudonana	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_17704\|UniProtKB=B8BTW9	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H379_PHYRM\|UniProtKB=H3H379	Phytophthora ramorum	LDO
PHYRM\|Gene=H3G567_PHYRM\|UniProtKB=H3G567	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_03g194250v5\|UniProtKB=A0A2K3DYK1	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00111p00123040\|UniProtKB=W1NZW7	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_46G00380\|UniProtKB=A0A0K9P058	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_110G00360\|UniProtKB=A0A0K9Q5K2	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma11_g21330\|UniProtKB=A0A804LA96	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_023056mg\|UniProtKB=K3Z936	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G257600\|UniProtKB=A0A1Z5RFH8	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb389020\|UniProtKB=A0A804R229	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb296140\|UniProtKB=A0A804UCE8	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb433120\|UniProtKB=A0A804RJN8	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb389030\|UniProtKB=A0A804R4Y2	Zea mays	O
BRADI\|EnsemblGenome=BRADI_5g25427v3\|UniProtKB=A0A2K2CJ85	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0208500\|UniProtKB=F2E5N9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G538800\|UniProtKB=A0A3B6B8W6	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCSU02G021000\|UniProtKB=A0A3B6U9D7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G539700\|UniProtKB=A0A1D5UV74	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_031042mg\|UniProtKB=K3ZWR0	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G167400\|UniProtKB=C5YDE1	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb427920\|UniProtKB=B6SI96	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0185670\|UniProtKB=F2DL47	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2D02G391100\|UniProtKB=A0A1D5UQT2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G393000\|UniProtKB=A0A3B6B311	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G411100\|UniProtKB=A0A3B6CAF3	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_017988mg\|UniProtKB=K3YUP2	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3004G297300\|UniProtKB=C5XS03	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb249260\|UniProtKB=A0A1D6HEZ2	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb186330\|UniProtKB=B6TLS0	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os02g0654500\|UniProtKB=Q6H7H9	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_3g50470v3\|UniProtKB=A0A2K2D4G1	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0600120\|UniProtKB=A0A8I6Y358	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS6B02G281200\|UniProtKB=A0A3B6PNL1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G243000\|UniProtKB=A0A3B6NSB4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G225300\|UniProtKB=A0A3B6QI12	Triticum aestivum	LDO
NELNU\|Gene=LOC104610496\|UniProtKB=A0A1U8BFZ3	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110795373\|UniProtKB=A0A9R0K2J0	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0745221\|UniProtKB=A0A251S2Y7	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900467390\|UniProtKB=A0A9R1WV32	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a013013mg\|UniProtKB=A0A022PXD5	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_16959\|UniProtKB=A0A2G2ZA69	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400024158\|UniProtKB=M1C8G8	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc06g060850.3\|UniProtKB=A0A3Q7HQP8	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107786199\|UniProtKB=A0A1S3ZFB3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107771406\|UniProtKB=A0A1S3Y1Z6	Nicotiana tabacum	LDO
CAPAN\|EnsemblGenome=T459_00696\|UniProtKB=A0A2G3AF08	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400026229\|UniProtKB=M1CHB4	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc08g078140.3\|UniProtKB=A0A3Q7HSN9	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107816171\|UniProtKB=A0A1S4C7W9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107760663\|UniProtKB=A0A1S3X3F4	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi02g01777\|UniProtKB=D7T5I6	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_E00375\|UniProtKB=A0A059C156	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C07P48810.1\|UniProtKB=A0A078FC87	Brassica napus	O
BRACM\|EnsemblGenome=Bra012660\|UniProtKB=M4D850	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C01P11160.1\|UniProtKB=A0A078HKJ9	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A01P09590.1\|UniProtKB=A0A078JKJ7	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra040160\|UniProtKB=A0A3P5Z6A3	Brassica campestris	LDO
ARATH\|TAIR=locus=2129151\|UniProtKB=Q8GWE1	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107939699\|UniProtKB=A0A1U8MSN1	Gossypium hirsutum	O
GOSHI\|Gene=LOC107939903\|UniProtKB=A0A1U8MPL5	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_015896\|UniProtKB=A0A061G3U9	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_003G081000v3\|UniProtKB=A0A2K2B3H3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_01G085700\|UniProtKB=A0A2C9WJ28	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_02G042700\|UniProtKB=A0A2C9WCB6	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0191600\|UniProtKB=B9T288	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_01G206200\|UniProtKB=K7K4Y1	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_17G145500\|UniProtKB=I1MV53	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_05G063800\|UniProtKB=A0A0R0K2F0	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g100360\|UniProtKB=G7JHN2	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr15_07860\|UniProtKB=A0A2I4E7T6	Juglans regia	O
JUGRE\|EnsemblGenome=Jr15_07870\|UniProtKB=A0A2I4E7W1	Juglans regia	O
JUGRE\|EnsemblGenome=Jr09_05760\|UniProtKB=A0A2I4F0G2	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_3G017310\|UniProtKB=A0A0A0L5F5	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_5G061500\|UniProtKB=M5WVD2	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_77814\|UniProtKB=D8QRL6	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_95093\|UniProtKB=D8RJ95	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c3_8410\|UniProtKB=A0A2K1KTQ9	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0021s0071\|UniProtKB=A0A2R6XDS7	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_003190030\|UniProtKB=A0A1Y1IAB0	Klebsormidium nitens	LDO