PANTHER Gene Information   
Gene Symbol(s): Ccne1
Organism: Rattus norvegicus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: G1_S-specific cyclin-E1
Gene ID: 2294
Protein ID: P39949
Persistent Id: PTN000020553
Alternate Ids:
D63164(EMBL) Ccne(Synonym)
O09138(AltAccession) 413911(GI)
BAA09640(EMBL-CDS) 2294(RGD)
Ccne1(Symbol) CCNE1_RAT(UniProtKB-ID)
Show All

PANTHER Classification
PANTHER Family: CYCLINS (PTHR10177)
PANTHER Subfamily: G1_S-SPECIFIC CYCLIN-E1 (PTHR10177:SF71)  
PANTHER GO-slim Molecular Function: protein kinase regulator activity
PANTHER GO-slim Biological Process: G1/S transition of mitotic cell cycle
positive regulation of cell cycle G1/S phase transition
positive regulation of mitotic cell cycle
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of G1/S transition of mitotic cell cycle
PANTHER GO-slim Cellular Component: centrosome
nucleus
cyclin-dependent protein kinase holoenzyme complex
cytoplasm
PANTHER protein class: kinase activator
Pathway Categories: Parkinson disease
   Cyclin E
Cell cycle
   Cyclin E
p53 pathway
   Cyclin E
p53 pathway feedback loops 2
   cyclin E
Cell cycle
   CdkC
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, protein binding, cyclin-dependent protein serine/threonine kinase regulator activity, kinase activity, protein-containing complex binding
GO BP Complete: response to cytokine, response to progesterone, response to xenobiotic stimulus, chromosome organization involved in meiotic cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of transcription by RNA polymerase II, cell division, response to ethanol, antral ovarian follicle growth, liver development, G1/S transition of mitotic cell cycle, Wnt signaling pathway, regulation of cell cycle, DNA replication initiation, positive regulation of G1/S transition of mitotic cell cycle, cellular response to nutrient, regulation of protein localization, response to vitamin E, positive regulation of mesenchymal stem cell proliferation, response to purine-containing compound, telomere maintenance, positive regulation of cell differentiation, response to organic cyclic compound, response to steroid hormone, homologous chromosome pairing at meiosis, response to corticosterone, response to methylmercury, response to estradiol, animal organ regeneration
GO CC Complete: nucleus, centrosome, cyclin E1-CDK2 complex, cytoplasm, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, p53-Dependent G1 DNA Damage Response, G0 and Early G1, Cellular Senescence, DNA Damage/Telomere Stress Induced Senescence, Cellular responses to stress, S Phase, SCF(Skp2)-mediated degradation of p27/p21, Cyclin E associated events during G1/S transition , Cell Cycle Checkpoints, Cellular responses to stimuli, TP53 Regulates Transcription of Cell Cycle Genes, p53-Dependent G1/S DNA damage checkpoint, PTK6 Regulates Cell Cycle, G1/S DNA Damage Checkpoints, Synthesis of DNA, Transcriptional Regulation by TP53, Signaling by PTK6, RHOBTB3 ATPase cycle, Gene expression (Transcription), Cell Cycle, Mitotic, Cyclin D associated events in G1, Cyclin A:Cdk2-associated events at S phase entry, Cell Cycle, CDK-mediated phosphorylation and removal of Cdc6, G1 Phase, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Switching of origins to a post-replicative state, RNA Polymerase II Transcription, Generic Transcription Pathway, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest, Mitotic G1 phase and G1/S transition, DNA Replication, G1/S Transition, Signaling by Non-Receptor Tyrosine Kinases

Orthologs