PANTHER Gene Information

Gene Symbol(s):

Syt4

Organism:

Mus musculus

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Gene Name:

Synaptotagmin-4

Gene ID:

MGI:101759

Protein ID:

P40749

Persistent Id:

PTN000001434

Alternate Ids:

ENSMUSP00000025110(Ensembl_PRO)	NM_009308(refSeq)
20983(GeneID)	Synaptotagmin IV(Synonym)
SYT4_MOUSE(UniProtKB-ID)	MGI:101759(MGI)
AK050515(EMBL)	Q8BGH3(AltAccession)
Syt4(Symbol)	74221752(GI)
BAE28640(EMBL-CDS)	ENSMUST00000025110(Ensembl_TRS)
ENSMUSG00000024261(Ensembl)
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PANTHER Classification

PANTHER Family:	SYNAPTOTAGMIN (PTHR10024)
PANTHER Subfamily:	SYNAPTOTAGMIN-4 (PTHR10024:SF114)
PANTHER GO-slim Molecular Function:	phosphatidylserine binding calcium ion binding clathrin binding SNARE binding
PANTHER GO-slim Biological Process:	vesicle fusion calcium-ion regulated exocytosis synaptic vesicle exocytosis
PANTHER GO-slim Cellular Component:	exocytic vesicle synapse plasma membrane axon
PANTHER protein class:	membrane trafficking regulatory protein

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

Syt IV

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	syntaxin-3 binding, phosphatidylserine binding, protein homodimerization activity, syntaxin binding, metal ion binding, protein heterodimerization activity, calcium ion binding, syntaxin-1 binding, SNARE binding, clathrin binding, calcium-dependent phospholipid binding
GO BP Complete:	positive regulation of dendrite extension, secretory granule maturation, regulation of postsynaptic dense core vesicle exocytosis, memory, regulation of vesicle fusion, negative regulation of vesicle fusion, synaptic vesicle transport, regulation of endocytosis, regulation of dopamine secretion, vesicle fusion with vesicle, negative regulation of protein secretion, negative regulation of neurotransmitter secretion, negative regulation of retrograde trans-synaptic signaling by neuropeptide, positive regulation of dense core granule exocytosis, negative regulation of dense core granule exocytosis, negative regulation of calcium ion-dependent exocytosis, neurotransmitter secretion, regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission, calcium ion-regulated exocytosis of neurotransmitter, negative regulation of catecholamine secretion, negative regulation of short-term neuronal synaptic plasticity, vesicle fusion, cell differentiation, dense core granule cytoskeletal transport, regulation of calcium ion-dependent exocytosis, positive regulation of glutamate secretion, negative regulation of synaptic vesicle exocytosis
GO CC Complete:	somatodendritic compartment, Golgi apparatus, neuronal cell body, synapse, neuron projection, neuronal dense core vesicle membrane, plasma membrane, neuron projection terminus, exocytic vesicle, dendrite, secretory granule membrane, presynapse, perinuclear region of cytoplasm, postsynapse, neuronal dense core vesicle, microvesicle, membrane, astrocyte projection, cytoplasmic vesicle, vesicle, dense core granule, glutamatergic synapse, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=11512\|UniProtKB=Q9H2B2	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009985.5\|UniProtKB=A0A2J8MMH3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006097.3\|UniProtKB=G3QTE9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017016.4\|UniProtKB=F6PMB2	Macaca mulatta	LDO
RAT\|RGD=68397\|UniProtKB=P50232	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000001801.4\|UniProtKB=A5D7F2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000037079.3\|UniProtKB=A0A287A0G7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017570.4\|UniProtKB=F6QVY0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000033996.3\|UniProtKB=A0A2I2UXW1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845003717.1\|UniProtKB=A0A8I3RRK8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000000187.4\|UniProtKB=F6TFY1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000002748.3\|UniProtKB=F6TDM4	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010012160.1\|UniProtKB=A0A1D5PCG4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014117.3\|UniProtKB=G1KPI2	Anolis carolinensis	LDO
XENLA\|Gene=syt4.S\|UniProtKB=A0A1L8HS71	Xenopus laevis	O
XENLA\|Gene=syt4.L\|UniProtKB=Q6GLR1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5963049\|UniProtKB=B3DLI1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000004098.2\|UniProtKB=A0A3B3I5D2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-7297\|UniProtKB=Q6PBU6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009420.1\|UniProtKB=W5MSY5	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409560\|UniProtKB=A0A9J7MFP3	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100889278\|UniProtKB=A0A7M7N985	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00020861\|UniProtKB=Q23056	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00038451\|UniProtKB=A8XV13	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00004924\|UniProtKB=P91493	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00033546\|UniProtKB=A8XG70	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00306036\|UniProtKB=A0A8R1Z3V2	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0028400\|UniProtKB=Q9U6P7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001800\|UniProtKB=Q7PY93	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC011462\|UniProtKB=D6X4X4	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_442626\|UniProtKB=E9GFT3	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW009095\|UniProtKB=B7PXT8	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG63739\|UniProtKB=T1FXJ4	helobdella robusta	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g135177\|UniProtKB=A7SWF3	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g242883\|UniProtKB=A7S4Y1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g97106\|UniProtKB=A7RXY7	Nematostella vectensis	O
TRIAD\|Gene_ORFName=TRIADDRAFT_53128\|UniProtKB=B3RND7	Trichoplax adhaerens	O
TRIAD\|Gene_ORFName=TRIADDRAFT_54566\|UniProtKB=B3RSE3	Trichoplax adhaerens	O
TRIAD\|Gene_ORFName=TRIADDRAFT_32942\|UniProtKB=B3SBZ5	Trichoplax adhaerens	O