PANTHER Gene Information   
Gene Symbol(s): Top2a
Organism: Rattus norvegicus
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Gene Name: DNA topoisomerase 2-alpha
Gene ID: 62048
Protein ID: P41516
Persistent Id: PTN000018909
Alternate Ids:
5.6.2.2 {ECO:0000255|PROSITE-ProRule:PRU00995}(EC) 57964(GI)
TOP2A_RAT(UniProtKB-ID) NP_071519(refSeq)
CAA79611(EMBL-CDS) Z19552(EMBL)
DNA topoisomerase II, alpha isozyme(Synonym) Top2a(Symbol)
62048(RGD) CHEMBL3400(ChEMBL)
360243(GeneID)
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PANTHER Classification
PANTHER Family: DNA TOPOISOMERASE/GYRASE (PTHR10169)
PANTHER Subfamily: DNA TOPOISOMERASE 2-ALPHA (PTHR10169:SF61)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: resolution of meiotic recombination intermediates
sister chromatid segregation
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: DNA metabolism protein
Pathway Categories: DNA replication
   DNA Topoisomerase
DNA replication
   Topoisomerase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase C binding, ATP-dependent activity, acting on DNA, protein homodimerization activity, DNA binding, bending, sequence-specific DNA binding, chromatin binding, magnesium ion binding, DNA binding, ATP binding, ubiquitin binding, metal ion binding, protein heterodimerization activity, DNA topoisomerase activity, DNA negative supercoiling activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO BP Complete: embryonic cleavage, sister chromatid segregation, cerebellar granule cell differentiation, negative regulation of DNA duplex unwinding, cerebellar Purkinje cell differentiation, female meiotic nuclear division, chromosome condensation, DNA ligation, resolution of meiotic recombination intermediates, chromosome segregation, DNA topological change, response to xenobiotic stimulus, DNA damage response, regulation of circadian rhythm, positive regulation of transcription by RNA polymerase II, hematopoietic progenitor cell differentiation, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, rhythmic process, positive regulation of apoptotic process, apoptotic chromosome condensation, response to parathyroid hormone, response to ionizing radiation
GO CC Complete: condensed chromosome, nucleus, cytoplasm, centriole, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, nuclear chromosome, protein-containing complex, chromosome, centromeric region, nucleolus, ribonucleoprotein complex, male germ cell nucleus, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: SUMOylation of DNA replication proteins, SUMO E3 ligases SUMOylate target proteins, SUMOylation, Metabolism of proteins, Post-translational protein modification

Orthologs