PANTHER Gene Information

Gene Symbol(s):

GLR1

Organism:

Saccharomyces cerevisiae

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Gene Name:

Glutathione reductase

Gene ID:

S000006012

Protein ID:

P41921

Persistent Id:

PTN000530601

Alternate Ids:

AAA92575(EMBL-CDS)	1.8.1.7 {ECO:0000269\|PubMed:7737505}(EC)
GLR1{ECO:0000303\|PubMed:7737505}(Symbol)	GSHR(Synonym)
CHEMBL4119(ChEMBL)	D37871(EMBL)
6325166(GI)	YPL091W(Ensembl)
S000006012(SGD)	856014(GeneID)
D6W3S6(AltAccession)	YEAST:YPL091W-MON(BioCyc)
GSHR_YEAST(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	GLUTATHIONE REDUCTASE (PTHR42737)
PANTHER Subfamily:	GLUTATHIONE REDUCTASE (PTHR42737:SF2)
PANTHER GO-slim Molecular Function:	antioxidant activity flavin adenine dinucleotide binding disulfide oxidoreductase activity
PANTHER GO-slim Biological Process:	cellular response to oxidative stress glutathione metabolic process cellular homeostasis
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	reductase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	NADP binding, oxidoreductase activity, flavin adenine dinucleotide binding, glutathione-disulfide reductase (NADPH) activity
GO BP Complete:	glutathione metabolic process, cellular oxidant detoxification, protein glutathionylation, cellular response to oxidative stress, cell redox homeostasis
GO CC Complete:	nucleus, peroxisome, cytoplasm, mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Interconversion of nucleotide di- and triphosphates, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Metabolism of nucleotides, Transcriptional Regulation by TP53, RNA Polymerase II Transcription, Gene expression (Transcription), TP53 Regulates Metabolic Genes, Generic Transcription Pathway, Cellular response to chemical stress, Cellular responses to stimuli

Orthologs

ID	Organism	Type
PIG\|Ensembl=ENSSSCG00000000843.5\|UniProtKB=A0A5G2RAB5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000046117.1\|UniProtKB=A0A9L0S254	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845006566.1\|UniProtKB=A0A8I3RUW0	Canis lupus familiaris	O
XENLA\|Gene=txnrd1.S\|UniProtKB=A0A8J0QGE1	Xenopus laevis	O
XENLA\|Gene=txnrd1.L\|UniProtKB=A0A8J0Q013	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-956002\|UniProtKB=A0A8J0QGX3	Xenopus tropicalis	O
PIG\|Ensembl=ENSSSCG00000010131.5\|UniProtKB=A0A5G2RKP4	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000026879.4\|UniProtKB=A0A3Q2LQS7	Equus caballus	O
CANLF\|Ensembl=ENSCAFG00845028764.1\|UniProtKB=A0A8I3Q1U6	Canis lupus familiaris	O
XENLA\|Gene=txnrd2.S\|UniProtKB=Q7T0L5	Xenopus laevis	O
XENTR\|Gene=txnrd2\|UniProtKB=A0A8J0QA84	Xenopus tropicalis	O
MACMU\|Ensembl=ENSMMUG00000001714.4\|UniProtKB=A0A1D5R2Q4	Macaca mulatta	O
CANLF\|Ensembl=ENSCAFG00845012644.1\|UniProtKB=A0A8I3NPC6	Canis lupus familiaris	O
CHICK\|Ensembl=ENSGALG00010021129.1\|UniProtKB=A0A8V0ZNY0	Gallus gallus	O
XENLA\|Gene=txnrd3.L\|UniProtKB=A0A8J0PYE6	Xenopus laevis	O
XENLA\|Gene=txnrd3.S\|UniProtKB=A0A8J0QGF0	Xenopus laevis	O
XENTR\|Gene=txnrd3\|UniProtKB=A0A8J0QHH9	Xenopus tropicalis	O
HUMAN\|HGNC=4623\|UniProtKB=P00390	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020138.6\|UniProtKB=H2QVZ8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002336.3\|UniProtKB=G3QIT1	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000039030.2\|UniProtKB=A0A1D5QYN2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=95804\|UniProtKB=P47791	Mus musculus	LDO
RAT\|RGD=621747\|UniProtKB=P70619	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000007115.6\|UniProtKB=E1BKZ1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000015844.5\|UniProtKB=F1RX66	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014178.3\|UniProtKB=F7DTP2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000001476.6\|UniProtKB=A0A337S9U4	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845016475.1\|UniProtKB=A0A8I3P561	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019004.4\|UniProtKB=A0A5F8GPA5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044221.1\|UniProtKB=A0A6I8N769	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010008016.1\|UniProtKB=A0A8V0XZZ4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003289.4\|UniProtKB=H9G7F5	Anolis carolinensis	LDO
XENLA\|Gene=gsr.L\|UniProtKB=A0A8J0Q217	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-997099\|UniProtKB=A0A6I8RRT3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000624.2\|UniProtKB=H2L4S2	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050522-116\|UniProtKB=A0A8M6Z2M1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012126.1\|UniProtKB=W5N2R8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003772.3\|UniProtKB=F7AVB6	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118426884\|UniProtKB=A0A9J7N763	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC589396\|UniProtKB=A0A7M7NKV5	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00008117\|UniProtKB=Q93379	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG09773\|UniProtKB=A8X9L3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00113337\|UniProtKB=A0A2A6BEZ1	Pristionchus pacificus	LDO
IXOSC\|EnsemblGenome=ISCW000888\|UniProtKB=B7P5Y6	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g164144\|UniProtKB=A7RYC0	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG52087\|UniProtKB=B3RLQ8	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_38979\|UniProtKB=A9VBC9	Monosiga brevicollis	LDO
EREGS\|EnsemblGenome=AGOS_AGR196W\|UniProtKB=Q74ZK4	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000194377\|UniProtKB=Q59NQ5	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E18029g\|UniProtKB=Q6C5H4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_00932\|UniProtKB=C8VUN9	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_1G15960\|UniProtKB=Q4WRK8	Neosartorya fumigata	O
SCLS1\|EnsemblGenome=SS1G_05927\|UniProtKB=A7EKT0	Sclerotinia sclerotiorum	O
NEUCR\|EnsemblGenome=NCU03339\|UniProtKB=Q873E8	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_10724\|UniProtKB=A7EZF7	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_05420\|UniProtKB=Q0US44	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC17A3.07\|UniProtKB=P78965	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01162\|UniProtKB=B6JZX4	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNE01560\|UniProtKB=Q5KH19	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_11644\|UniProtKB=A0A0D1CDS2	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16679\|UniProtKB=E3L278	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_21097\|UniProtKB=F4PEJ7	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0272754\|UniProtKB=Q8T137	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_93030\|UniProtKB=F1A119	Dictyostelium purpureum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_268657\|UniProtKB=B8BYY9	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_21619\|UniProtKB=B8BWY9	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPS_41433\|UniProtKB=B5YNT2	Thalassiosira pseudonana	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_41979\|UniProtKB=B8LBU8	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GA84_PHYRM\|UniProtKB=H3GA84	Phytophthora ramorum	LDO
PHYRM\|Gene=H3GA09_PHYRM\|UniProtKB=H3GA09	Phytophthora ramorum	LDO
MARPO\|EnsemblGenome=MARPO_0001s0404\|UniProtKB=A0A2R6XWE5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000120050\|UniProtKB=A0A1Y1HP55	Klebsormidium nitens	O
MUSAM\|EnsemblGenome=Ma05_g16590\|UniProtKB=A0A804J566	Musa acuminata subsp. malaccensis	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0628590\|UniProtKB=A0A8I6YNY2	Hordeum vulgare subsp. vulgare	LDO
JUGRE\|Gene=LOC118348891\|UniProtKB=A0A6P9EIX4	Juglans regia	LDO
MARPO\|EnsemblGenome=MARPO_0002s0333\|UniProtKB=A0A2R6XUV2	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_002140050\|UniProtKB=A0A1Y1I730	Klebsormidium nitens	LDO
STRR6\|EnsemblGenome=spr0692\|UniProtKB=Q8DQG0	Streptococcus pneumoniae	LDO
LISMO\|Gene=Q8Y8J5_LISMO\|UniProtKB=Q8Y8J5	Listeria monocytogenes	LDO
HAEIN\|EnsemblGenome=HI_0161\|UniProtKB=P43783	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_4702\|UniProtKB=Q8E8G2	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0186\|UniProtKB=Q9KVG0	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC2579\|UniProtKB=Q8P7N2	Xanthomonas campestris	LDO
SALTY\|EnsemblGenome=STM3597\|UniProtKB=Q8ZLD4	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO3977\|UniProtKB=A0A5P8YLU9	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAE77794\|UniProtKB=P06715	Escherichia coli	LDO