PANTHER Gene Information

Gene Symbol(s):

Kcnj12

Organism:

Rattus norvegicus

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Gene Name:

ATP-sensitive inward rectifier potassium channel 12

Gene ID:

621660

Protein ID:

P52188

Persistent Id:

PTN000205895

Alternate Ids:

Irk2(Synonym)	Kcnj12(Symbol)
KCJ12_RAT(UniProtKB-ID)	CAA55216(EMBL-CDS)
510667(GI)	621660(RGD)
X78461(EMBL)
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PANTHER Classification

PANTHER Family:	INWARD RECTIFIER POTASSIUM CHANNEL (PTHR11767)
PANTHER Subfamily:	ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 12-RELATED (PTHR11767:SF14)
PANTHER GO-slim Molecular Function:	ligand-gated monoatomic cation channel activity voltage-gated potassium channel activity
PANTHER GO-slim Biological Process:	potassium ion import across plasma membrane regulation of monoatomic ion transmembrane transport
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	ion channel

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein binding, inward rectifier potassium channel activity, PDZ domain binding
GO BP Complete:	potassium ion transport, potassium ion import across plasma membrane, protein homotetramerization, potassium ion transmembrane transport, regulation of monoatomic ion transmembrane transport
GO CC Complete:	T-tubule, dendrite, membrane, neuronal cell body, monoatomic ion channel complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Phase 4 - resting membrane potential, Muscle contraction, GABA B receptor activation, G protein gated Potassium channels, Neuronal System, Transmission across Chemical Synapses, Neurotransmitter receptors and postsynaptic signal transmission, Potassium Channels, Activation of GABAB receptors, GABA receptor activation, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Classical Kir channels, Activation of G protein gated Potassium channels, Cardiac conduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=39080\|UniProtKB=B7U540	Homo sapiens	O
HUMAN\|HGNC=6258\|UniProtKB=Q14500	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000046193.1\|UniProtKB=A0A2I3TCL5	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000043241.1\|UniProtKB=K7B7L4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000040998.1\|UniProtKB=A0A2I2ZUY2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000056831.1\|UniProtKB=F7GLZ2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=108495\|UniProtKB=P52187	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000020061\|UniProtKB=Q4TZY1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000034773.2\|UniProtKB=A0A287A5K0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000003664.3\|UniProtKB=F6XH91	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000040315.2\|UniProtKB=A0A337RXG7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026512.1\|UniProtKB=F6KIF6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001377.4\|UniProtKB=F7FJC1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000007731.4\|UniProtKB=F6PXI5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010021526\|UniProtKB=F1NHE9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001841.2\|UniProtKB=H9G5K9	Anolis carolinensis	LDO
XENLA\|Gene=kcnj12.L\|UniProtKB=A0A1L8EX89	Xenopus laevis	O
XENLA\|Gene=kcnj12.S\|UniProtKB=A0A1L8EPY8	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6048235\|UniProtKB=A0A803K0G9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011503.2\|UniProtKB=H2M7F4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000008168.2\|UniProtKB=H2LVX0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-091118-79\|UniProtKB=E7F807	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-131126-14\|UniProtKB=A0A0R4ICH9	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000018090.1\|UniProtKB=W5NNI2	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008277.3\|UniProtKB=F6QHN7	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118428454\|UniProtKB=A0A9J7M4Z7	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC584140\|UniProtKB=A0A7M7NLD4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918598\|UniProtKB=A0A7M7NRA6	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC584158\|UniProtKB=A0A7M7NRN0	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592565\|UniProtKB=A0A7M7LSG3	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00002151\|UniProtKB=A0A1C3NSK2	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG10649\|UniProtKB=A8XBI7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096471\|UniProtKB=A0A2A6B4B2	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002149\|UniProtKB=P52192	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG10884\|UniProtKB=A8XC74	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00002150\|UniProtKB=A0A1C3NSN6	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG08126\|UniProtKB=A8X5V6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00203627\|UniProtKB=A0A2A6CGW5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0032706\|UniProtKB=B7YZX2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007818\|UniProtKB=A0A1S4GX11	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP028144\|UniProtKB=A0A1S4HEA1	Anopheles gambiae	O
DROME\|FlyBase=FBgn0039081\|UniProtKB=A0A0B4LHI9	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001283\|UniProtKB=Q7PX91	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP001284\|UniProtKB=Q7PKL0	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP001281\|UniProtKB=Q7PKK8	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC034483\|UniProtKB=A0A139WBX6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006707\|UniProtKB=D6WYJ8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033608\|UniProtKB=A0A139WFH2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006708\|UniProtKB=D6WYJ9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC001199\|UniProtKB=D6WAQ3	Tribolium castaneum	O
DROME\|FlyBase=FBgn0265042\|UniProtKB=A0A0B4KH86	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP029806\|UniProtKB=A0A499FWX7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC006706\|UniProtKB=D6WYJ7	Tribolium castaneum	LDO
DAPPU\|Gene_ORFName=DAPPUDRAFT_42289\|UniProtKB=E9FXS2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_311738\|UniProtKB=E9FXS0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW016219\|UniProtKB=B7P0N6	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG107917\|UniProtKB=T1EED8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG157415\|UniProtKB=T1EMB1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG179553\|UniProtKB=T1FEV3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG122541\|UniProtKB=T1EGU9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG79786\|UniProtKB=T1G3T3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG73033\|UniProtKB=T1G190	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG108208\|UniProtKB=T1EEG9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82781\|UniProtKB=T1G4W5	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG122071\|UniProtKB=T1EGT8	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG82544\|UniProtKB=T1G4T5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG122255\|UniProtKB=T1EGU3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG106279\|UniProtKB=T1EE13	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g52170\|UniProtKB=A7SE20	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g170615\|UniProtKB=A7SH65	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g101684\|UniProtKB=A7S217	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93919\|UniProtKB=A7RUM3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG3835\|UniProtKB=B3RMY4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25718\|UniProtKB=A9V082	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_24696\|UniProtKB=A9UX72	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_32445\|UniProtKB=A9UZJ5	Monosiga brevicollis	LDO
LEIMA\|EnsemblGenome=LMJF_09_0480\|UniProtKB=Q4QHX6	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb11.01.4330\|UniProtKB=Q382T2	Trypanosoma brucei	LDO
THAPS\|EnsemblGenome=THAPS_25330\|UniProtKB=B5YLJ0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_24946\|UniProtKB=B8CCX1	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_21089\|UniProtKB=B8BSL6	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_5256\|UniProtKB=B8C2E6	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3HCM1_PHYRM\|UniProtKB=H3HCM1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_01g035800v5\|UniProtKB=A0A2K3E712	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g311650v5\|UniProtKB=A0A2K3DRT3	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g591450v5\|UniProtKB=A0A2K3D141	Chlamydomonas reinhardtii	LDO
PHYPA\|EnsemblGenome=Pp3c15_3810\|UniProtKB=A0A7I3Z5Z2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c9_4440\|UniProtKB=A0A2K1K204	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0015s0176\|UniProtKB=A0A2R6XH25	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_005570020\|UniProtKB=A0A1Y1II39	Klebsormidium nitens	LDO