PANTHER Gene Information   
Gene Symbol(s): Msh2
Organism: Rattus norvegicus
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Gene Name: DNA mismatch repair protein Msh2
Gene ID: 620786
Protein ID: P54275
Persistent Id: PTN000145657
Alternate Ids:
X93591(EMBL) 1709122(GI)
Msh2(Symbol) CAA63789(EMBL-CDS)
620786(RGD) MutS protein homolog 2(Synonym)
MSH2_RAT(UniProtKB-ID) 81709(GeneID)
NP_112320(refSeq)
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PANTHER Classification
PANTHER Family: DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER (PTHR11361)
PANTHER Subfamily: DNA MISMATCH REPAIR PROTEIN MSH2 (PTHR11361:SF35)  
PANTHER GO-slim Molecular Function: double-stranded DNA binding
PANTHER GO-slim Biological Process: mitotic recombination
mismatch repair
PANTHER GO-slim Cellular Component: nuclear protein-containing complex
PANTHER protein class: DNA metabolism protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP hydrolysis activity, ATP-dependent activity, acting on DNA, dinucleotide repeat insertion binding, protein homodimerization activity, single guanine insertion binding, single thymine insertion binding, double-stranded DNA binding, chromatin binding, ADP binding, four-way junction DNA binding, damaged DNA binding, single-stranded DNA binding, magnesium ion binding, DNA binding, ATP binding, MutLalpha complex binding, ATP-dependent DNA damage sensor activity, mismatched DNA binding, dinucleotide insertion or deletion binding, centromeric DNA binding, guanine/thymine mispair binding, oxidized purine DNA binding
GO BP Complete: somatic recombination of immunoglobulin gene segments, DNA repair, response to X-ray, male gonad development, determination of adult lifespan, response to amino acid, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of helicase activity, response to xenobiotic stimulus, postreplication repair, double-strand break repair, negative regulation of neuron apoptotic process, oxidative phosphorylation, maintenance of DNA repeat elements, in utero embryonic development, mitotic intra-S DNA damage checkpoint signaling, regulation of cell cycle, B cell mediated immunity, isotype switching, germ cell development, B cell differentiation, spermatogenesis, intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of isotype switching to IgG isotypes, mismatch repair, response to organic cyclic compound, DNA damage response, mitotic recombination, negative regulation of DNA recombination, positive regulation of isotype switching to IgA isotypes, somatic recombination of immunoglobulin genes involved in immune response, protein localization to chromatin, response to UV-B, somatic hypermutation of immunoglobulin genes
GO CC Complete: nucleus, MutSalpha complex, chromosome, MutSbeta complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), DNA Repair, Mismatch Repair

Orthologs