PANTHER Gene Information   
Gene Symbol(s): Srebf1
Organism: Rattus norvegicus
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Gene Name: Sterol regulatory element-binding protein 1
Gene ID: 69423
Protein ID: P56720
Persistent Id: PTN000285919
Alternate Ids:
69423(RGD) Adipocyte determination- and differentiation-dependent factor 1 {ECO:0000303|PubMed:11309661}(Synonym)
AF286469(EMBL) 78968(GeneID)
ENSRNOG00000003463(Ensembl) AAG28734(EMBL-CDS)
Q99PI6(AltAccession) 12249195(GI)
Srebf1{ECO:0000312|RGD:69423}(Symbol) SRBP1_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: STEROL REGULATORY ELEMENT-BINDING PROTEIN (PTHR46062)
PANTHER Subfamily: STEROL REGULATORY ELEMENT-BINDING PROTEIN 1 (PTHR46062:SF2)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: basic helix-loop-helix transcription factor
Pathway Categories: No pathway information available
GO MF Complete: protein kinase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, protein dimerization activity, chromatin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein-containing complex binding, transcription coregulator binding, DNA binding, DNA-binding transcription factor activity, nuclear receptor activity, sequence-specific double-stranded DNA binding, sterol response element binding
GO BP Complete: response to food, response to fructose, insulin secretion, response to progesterone, transcription by RNA polymerase II, fat cell differentiation, regulation of insulin secretion, response to glucose, response to retinoic acid, positive regulation of DNA-templated transcription, mRNA transcription by RNA polymerase II, regulation of heart rate by chemical signal, cholesterol biosynthetic process, response to nutrient, regulation of protein targeting to mitochondrion, response to organic cyclic compound, circadian rhythm, response to peptide hormone, positive regulation of triglyceride biosynthetic process, response to glucagon, insulin receptor signaling pathway, cholesterol metabolic process, response to cAMP, positive regulation of cholesterol biosynthetic process, positive regulation of miRNA transcription, response to xenobiotic stimulus, negative regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, regulation of mitophagy, negative regulation of transcription by RNA polymerase II, cellular response to insulin stimulus, response to ethanol, response to insulin, cellular response to fatty acid, response to lipid, response to fatty acid, lung development, intracellular receptor signaling pathway, lipid biosynthetic process, regulation of DNA-templated transcription, cellular response to starvation, regulation of transcription by RNA polymerase II, positive regulation of lipid biosynthetic process, SREBP signaling pathway, regulation of protein stability, positive regulation of innate immune response, negative regulation of triglyceride metabolic process, regulation of lipid storage, regulation of fatty acid metabolic process
GO CC Complete: endoplasmic reticulum membrane, nucleus, cytoplasm, ER to Golgi transport vesicle membrane, membrane, Golgi membrane, endoplasmic reticulum, protein-containing complex
Reactome Pathways: Metabolism, Metabolism of lipids, Regulation of cholesterol biosynthesis by SREBP (SREBF), Metabolism of steroids, Cholesterol biosynthesis