PANTHER Gene Information   
Gene Symbol(s): Tfap2a
Organism: Rattus norvegicus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Transcription factor AP-2-alpha
Gene ID: 1310267
Protein ID: P58197
Persistent Id: PTN000087755
Alternate Ids:
AP2A_RAT(UniProtKB-ID) Activator protein 2(Synonym)
14547908(GI) 1310267(RGD)
Tfap2a(Symbol)
Show All

PANTHER Classification
PANTHER Family: TRANSCRIPTION FACTOR AP-2 (PTHR10812)
PANTHER Subfamily: TRANSCRIPTION FACTOR AP-2-ALPHA (PTHR10812:SF8)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
regulation of cell population proliferation
anatomical structure development
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: general transcription factor
Pathway Categories: No pathway information available
GO MF Complete: identical protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, transcription cis-regulatory region binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity, protein binding, transcription coactivator activity, transcription corepressor activity, nuclear receptor corepressor activity, sequence-specific double-stranded DNA binding
GO BP Complete: trigeminal nerve development, epidermal growth factor receptor signaling pathway, transcription by RNA polymerase II, negative regulation of epidermal growth factor receptor signaling pathway, lens morphogenesis in camera-type eye, skin development, face morphogenesis, keratinocyte development, sensory perception of sound, sympathetic nervous system development, skeletal system development, optic vesicle morphogenesis, negative regulation of DNA-templated transcription, kidney development, positive regulation of DNA-templated transcription, optic cup structural organization, embryonic forelimb morphogenesis, positive regulation of bone mineralization, neuron apoptotic process, neural crest cell development, embryonic pattern specification, anterior neuropore closure, oculomotor nerve formation, lens induction in camera-type eye, sensory organ development, negative regulation of transcription by competitive promoter binding, epidermis morphogenesis, positive regulation of gene expression, inner ear morphogenesis, metanephric nephron development, cell population proliferation, Schwann cell development, negative regulation of cell population proliferation, roof of mouth development, outflow tract morphogenesis, nervous system development, bone morphogenesis, regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, cellular response to iron ion, positive regulation of neuron apoptotic process, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, neural tube closure, regulation of cell differentiation, basement membrane organization, forelimb morphogenesis, negative regulation of reactive oxygen species metabolic process, embryonic body morphogenesis, regulation of DNA-templated transcription, embryonic cranial skeleton morphogenesis, skeletal system morphogenesis, cornea development in camera-type eye, regulation of cell population proliferation, eyelid development in camera-type eye, regulation of transcription by RNA polymerase II, forebrain neuron development, positive regulation of tooth mineralization, negative regulation of apoptotic process, embryonic camera-type eye morphogenesis, retina layer formation, response to lipopolysaccharide, fibroblast migration, positive regulation of fibroblast migration
GO CC Complete: nucleus, clathrin-coated pit, nucleoplasm
Reactome Pathways: Specification of the neural plate border, Generic Transcription Pathway, Gastrulation, Developmental Biology, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Activation of the TFAP2 (AP-2) family of transcription factors, Gene expression (Transcription), TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, RNA Polymerase II Transcription