PANTHER Gene Information

Gene Symbol(s):

Itpr3

Organism:

Mus musculus

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Gene Name:

Inositol 1,4,5-trisphosphate receptor type 3

Gene ID:

MGI:96624

Protein ID:

P70227

Persistent Id:

PTN000346558

Alternate Ids:

Q91Z08(AltAccession)	1495698(GI)
ENSMUSG00000042644(Ensembl)	NM_080553(refSeq)
Z71174(EMBL)	BAC25977(EMBL-CDS)
Itpr3(Symbol)	ENSMUST00000049308(Ensembl_TRS)
MGI:96624(MGI)	Type 3 InsP3 receptor(Synonym)
16440(GeneID)	ENSMUSP00000038150(Ensembl_PRO)
ITPR3_MOUSE(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	RYANODINE RECEPTOR AND IP3 RECEPTOR (PTHR13715)
PANTHER Subfamily:	INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 3 (PTHR13715:SF51)
PANTHER GO-slim Molecular Function:	calcium ion binding alcohol binding phosphatidylinositol binding ligand-gated monoatomic cation channel activity calcium channel activity anion binding
PANTHER GO-slim Biological Process:	release of sequestered calcium ion into cytosol
PANTHER GO-slim Cellular Component:	plasma membrane endoplasmic reticulum membrane sarcoplasmic reticulum secretory granule membrane
PANTHER protein class:	ligand-gated ion channel

Pathway Categories:

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

IP3-gated calcium channel

Wnt signaling pathway

IP3 Gated Calcium Channel

B cell activation

inositol 1,4,5-triphosphate receptor

Histamine H1 receptor mediated signaling pathway

inositol 1,4,5-triphosphate receptor

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

inositol 1,4,5-triphosphate receptor 1

Endothelin signaling pathway

inositol 1,4,5-triphosphate receptor

Gonadotropin-releasing hormone receptor pathway

IP3R

PDGF signaling pathway

inositol 1,4,5-triphosphate receptor

Inflammation mediated by chemokine and cytokine signaling pathway

Inositol 1,4,5-triphosphate receptor

Angiotensin II-stimulated signaling through G proteins and beta-arrestin

inositol 1,4,5-triphosphate receptor

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP binding, intracellularly gated calcium channel activity, identical protein binding, protein binding, metal ion binding, calcium ion binding, inositol 1,4,5-trisphosphate-gated calcium channel activity, phosphatidylinositol binding, inositol hexakisphosphate binding, inositol 1,3,4,5 tetrakisphosphate binding, protein-containing complex binding, inositol 1,4,5 trisphosphate binding
GO BP Complete:	calcium ion homeostasis, G protein-coupled receptor signaling pathway, sensory perception of umami taste, sensory perception of sweet taste, memory, positive regulation of cytosolic calcium ion concentration, protein homotetramerization, response to calcium ion, calcium ion transport, cellular response to cAMP, sensory perception of bitter taste, calcium ion transmembrane transport, long-term synaptic potentiation, release of sequestered calcium ion into cytosol, calcium-mediated signaling, platelet activation
GO CC Complete:	sarcoplasmic reticulum, nuclear outer membrane, endoplasmic reticulum, receptor complex, neuronal cell body, nucleolus, plasma membrane, nucleoplasm, nuclear envelope, endoplasmic reticulum membrane, nucleus, dendrite, secretory granule membrane, cytoplasmic side of endoplasmic reticulum membrane, presynapse, transport vesicle membrane, perinuclear region of cytoplasm, brush border, apical part of cell, cytoplasm, apical plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Cardiac conduction, Regulation of insulin secretion, Signal Transduction, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Platelet homeostasis, G alpha (q) signalling events, Sensory perception of sweet, bitter, and umami (glutamate) taste, GPCR downstream signalling, Integration of energy metabolism, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Platelet calcium homeostasis, Signaling by the B Cell Receptor (BCR), Sensory perception of taste, Muscle contraction, Platelet activation, signaling and aggregation, Hemostasis, Effects of PIP2 hydrolysis, Elevation of cytosolic Ca2+ levels, Metabolism, Signaling by GPCR, Ion homeostasis, Sensory Perception, Adaptive Immune System

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6182\|UniProtKB=Q14573	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000018054.4\|UniProtKB=K7CRA5	Pan troglodytes	LDO
RAT\|RGD=2934\|UniProtKB=Q63269	Rattus norvegicus	LDO
BOVIN\|Gene=ITPR3\|UniProtKB=Q8WN95	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000013245.6\|UniProtKB=E1BKE7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000001518.5\|UniProtKB=A0A287BL11	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000007328.4\|UniProtKB=A0A3Q2LBD5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013659.6\|UniProtKB=M3WJ91	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845023922.1\|UniProtKB=A0A8I3Q2P2	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000014069.5\|UniProtKB=A0A5F8H1Y0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000011265.5\|UniProtKB=F7DPJ5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010027594.1\|UniProtKB=A0A8V1ACE6	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000016163.3\|UniProtKB=G1KSL8	Anolis carolinensis	LDO
XENLA\|Gene=LOC108709441\|UniProtKB=A0A1L8H6Q2	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1012312\|UniProtKB=A4ZYX8	Xenopus tropicalis	LDO
DANRE\|Gene=itpr3\|UniProtKB=A0A8M6Z0J4	Danio rerio	LDO
BRAFL\|Gene=LOC118415973\|UniProtKB=A0A9J7MRS8	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC594527\|UniProtKB=A0A7M7MY00	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00002173\|UniProtKB=Q9Y0A1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05938\|UniProtKB=H8WGV2	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00115426\|UniProtKB=A0A2A6BHW5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0010051\|UniProtKB=P29993	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP006475\|UniProtKB=A0A1S4GS95	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_227934\|UniProtKB=E9H9P2	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW023346\|UniProtKB=B7QKP6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g244707\|UniProtKB=A7SEK1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG56365\|UniProtKB=B3RXX7	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_29689\|UniProtKB=A9VBU8	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_37956\|UniProtKB=A9V4T6	Monosiga brevicollis	O
DICDI\|dictyBase=DDB_G0292564\|UniProtKB=Q9NA13	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_45096\|UniProtKB=F0Z8W1	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_16_0280\|UniProtKB=Q4QEZ2	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.8.2770\|UniProtKB=Q57XB2	Trypanosoma brucei	O
PARTE\|EnsemblGenome=GSPATT00016305001\|UniProtKB=A0DEL2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00034487001\|UniProtKB=A0C2J2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027332001\|UniProtKB=A0EI63	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013248001\|UniProtKB=A0D416	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011355001\|UniProtKB=A0CY56	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016586001\|UniProtKB=A0DFF6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023614001\|UniProtKB=A0E570	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007079001\|UniProtKB=A0CDK1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025110001\|UniProtKB=A0EAQ9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00001565001\|UniProtKB=A0CX44	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036177001\|UniProtKB=A0C8C7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011913001\|UniProtKB=A0CZX3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000020001\|UniProtKB=Q6BFC5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012469001\|UniProtKB=A0D1M8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008240001\|UniProtKB=A0CLM4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012849001\|UniProtKB=A0D2S4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003859001\|UniProtKB=A0ECH3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009868001\|UniProtKB=A0CS29	Paramecium tetraurelia	O
CHLRE\|EnsemblGenome=CHLRE_16g665450v5\|UniProtKB=A0A2K3CTW4	Chlamydomonas reinhardtii	O