PANTHER Gene Information

Gene Symbol(s):

Kynu

Organism:

Rattus norvegicus

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Gene Name:

Kynureninase

Gene ID:

71061

Protein ID:

P70712

Persistent Id:

PTN000363123

Alternate Ids:

NP_446354(refSeq)	Q68G25(AltAccession)
KYNU_RAT(UniProtKB-ID)	MetaCyc:MON-15007(BioCyc)
116682(GeneID)	71061(RGD)
51261163(GI)	AAH78762(EMBL-CDS)
3.7.1.3 {ECO:0000255\|HAMAP-Rule:MF_03017}(EC)	Kynu(Symbol)
CHEMBL2969(ChEMBL)	KYNU(Synonym)
U68168(EMBL)
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PANTHER Classification

PANTHER Family:	KYNURENINASE (PTHR14084)
PANTHER Subfamily:	KYNURENINASE (PTHR14084:SF0)
PANTHER GO-slim Molecular Function:	hydrolase activity
PANTHER GO-slim Biological Process:	monocarboxylic acid metabolic process amino acid catabolic process biogenic amine metabolic process aromatic amino acid family catabolic process alpha-amino acid metabolic process heterocycle catabolic process cellular nitrogen compound catabolic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	hydrolase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	pyridoxal phosphate binding, protein homodimerization activity, kynureninase activity
GO BP Complete:	tryptophan catabolic process, quinolinate biosynthetic process, 'de novo' NAD biosynthetic process from tryptophan, tryptophan catabolic process to kynurenine, response to type II interferon, NAD biosynthetic process, anthranilate metabolic process, tryptophan catabolic process to acetyl-CoA, response to vitamin B6, L-kynurenine catabolic process
GO CC Complete:	cytoplasm, mitochondrion, cytosol, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Tryptophan catabolism, Metabolism of amino acids and derivatives

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6469\|UniProtKB=Q16719	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012509.7\|UniProtKB=H2QIS6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007406.3\|UniProtKB=G3RXV2	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021330.4\|UniProtKB=F6URB1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1918039\|UniProtKB=Q9CXF0	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000032277.4\|UniProtKB=F1MCH2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000015673.5\|UniProtKB=F1S0H1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000018188.4\|UniProtKB=A0A3Q2KVR2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000018501.5\|UniProtKB=A0A5F5XMX8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845013520.1\|UniProtKB=A0A8I3S055	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002997.3\|UniProtKB=F6Q3X0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000045440.1\|UniProtKB=A0A6I8P7W7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009338.1\|UniProtKB=A0A8V0Y375	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003164.4\|UniProtKB=A0A803TNS6	Anolis carolinensis	LDO
XENLA\|Gene=kynu.L\|UniProtKB=A0A1L8EVT8	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000032399\|UniProtKB=A0A6I8PXQ1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005074.2\|UniProtKB=H2LK45	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-120215-204\|UniProtKB=A0A0R4IQY2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001250.1\|UniProtKB=W5LZ66	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000017067.2\|UniProtKB=F7A2G6	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000019860.1\|UniProtKB=H2XYS1	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000024316.1\|UniProtKB=H2XXH7	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000024622.1\|UniProtKB=H2XQ19	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000018272.1\|UniProtKB=H2XP90	Ciona intestinalis	O
BRAFL\|Gene=LOC118418061\|UniProtKB=A0A9J7MUV8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC754267\|UniProtKB=A0A7M7N130	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00015802\|UniProtKB=Q18026	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00035224\|UniProtKB=A8XKT0	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00117862\|UniProtKB=A0A2A6B7D8	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00117054\|UniProtKB=A0A2A6CK34	Pristionchus pacificus	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_310889\|UniProtKB=E9FVX1	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW005441\|UniProtKB=B7PL61	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG188733\|UniProtKB=T1FQB2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g235255\|UniProtKB=A7SCH8	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG58136\|UniProtKB=B3S0Z1	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG28018\|UniProtKB=B3S0Z2	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_26773\|UniProtKB=A9V3C0	Monosiga brevicollis	LDO
YEAST\|SGD=S000004221\|UniProtKB=Q05979	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AGL098W\|UniProtKB=Q750P5	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000197943\|UniProtKB=Q59QC4	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_B22902g\|UniProtKB=Q6CDM0	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_01857\|UniProtKB=Q5BC73	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G09840\|UniProtKB=Q4WPN0	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU09183\|UniProtKB=Q7S332	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_08223\|UniProtKB=A7ESB8	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_02814\|UniProtKB=Q0UZK0	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_05952\|UniProtKB=Q5B0H8	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G10360\|UniProtKB=Q4X1D4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU00463\|UniProtKB=Q7RXY2	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_00001\|UniProtKB=A7E3X9	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_08382\|UniProtKB=Q0UIN2	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNC03980\|UniProtKB=P0CO52	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_04846\|UniProtKB=A0A0D1DQV3	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_18997\|UniProtKB=E3L8V9	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_33380\|UniProtKB=F4P5P7	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0284203\|UniProtKB=Q54Q04	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_74692\|UniProtKB=F0Z8G9	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_26_2240\|UniProtKB=Q4Q8W8	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb09.160.0810\|UniProtKB=Q38FV7	Trypanosoma brucei	LDO
KLENI\|Gene_ORFName=KFL_001940090\|UniProtKB=A0A1Y1I3M4	Klebsormidium nitens	LDO
HALSA\|EnsemblGenome=VNG_0915G\|UniProtKB=Q9HR11	Halobacterium salinarum	LDO
CHLAA\|EnsemblGenome=Caur_1258\|UniProtKB=A9WK35	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO3645\|UniProtKB=Q9X8R2	Streptomyces coelicolor	LDO
DEIRA\|EnsemblGenome=DR_A0338\|UniProtKB=Q9RYH5	Deinococcus radiodurans	LDO
BRADU\|Gene=kynU\|UniProtKB=Q89MN3	Bradyrhizobium diazoefficiens	LDO
PSEAE\|EnsemblGenome=PA2080\|UniProtKB=Q9I235	Pseudomonas aeruginosa	LDO