PANTHER Gene Information

Gene Symbol(s):

leuC

Organism:

Methanocaldococcus jannaschii

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Gene Name:

Isopropylmalate_citramalate isomerase large subunit

Gene ID:

MJ_0499

Protein ID:

P81291

Persistent Id:

PTN002887816

Alternate Ids:

AAB98487(Ensembl_PRO)	(R)-2-methylmalate dehydratase(Synonym)
4.2.1.31(EC)	1451361(GeneID)
NC_000909(refSeq)	MetaCyc:MON-13647(BioCyc)
1591201(GI)	LEUC_METJA(UniProtKB-ID)
L77117(EMBL)	MJ_0499(Ensembl)
AAB98487(Ensembl_TRS)	AAB98487(EMBL-CDS)
leuC{ECO:0000255\|HAMAP-Rule:MF_01027}(Symbol)
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PANTHER Classification

PANTHER Family:	HOMOACONITASE, MITOCHONDRIAL-RELATED (PTHR43822)
PANTHER Subfamily:	ISOPROPYLMALATE_CITRAMALATE ISOMERASE LARGE SUBUNIT (PTHR43822:SF22)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:

Pathway Categories:

Leucine biosynthesis

Isopropylmalate isomerase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	(R)-2-methylmalate dehydratase activity, maleate hydratase activity, metal ion binding, lyase activity, 4 iron, 4 sulfur cluster binding, 3-isopropylmalate dehydratase activity
GO BP Complete:	isoleucine biosynthetic process, L-leucine biosynthetic process, carboxylic acid metabolic process
GO CC Complete:	-

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
MONBE\|EnsemblGenome=MONBRDRAFT_32374\|UniProtKB=A9UZ48	Monosiga brevicollis	O
YEAST\|SGD=S000002642\|UniProtKB=P49367	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABL106C\|UniProtKB=Q75DX9	Eremothecium gossypii	O
CANAL\|CGD=CAL0000195924\|UniProtKB=Q5A644	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E02728g\|UniProtKB=Q6C791	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_06521\|UniProtKB=Q92412	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_8G07140\|UniProtKB=Q4WBR0	Neosartorya fumigata	O
ASPFU\|EnsemblGenome=AFUA_5G08890\|UniProtKB=Q4WUL6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08898\|UniProtKB=Q870W1	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_01026\|UniProtKB=A7E6V1	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_01131\|UniProtKB=Q0V4D3	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC343.16\|UniProtKB=Q9UT74	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_01574\|UniProtKB=B6JYB3	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNK00580\|UniProtKB=P0CM02	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_10689\|UniProtKB=Q4P521	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_09399\|UniProtKB=E3KHB1	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_29162\|UniProtKB=F4NTQ0	Batrachochytrium dendrobatidis	O
PHYRM\|Gene=H3GUI6_PHYRM\|UniProtKB=H3GUI6	Phytophthora ramorum	O
PHYRM\|Gene=H3H3D6_PHYRM\|UniProtKB=H3H3D6	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_01g004500v5\|UniProtKB=A8JG03	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00039p00086570\|UniProtKB=U5CRC3	Amborella trichopoda	O
AMBTC\|EnsemblGenome=AMTR_s00039p00083280\|UniProtKB=U5D0J0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_15G01270\|UniProtKB=A0A0K9PUS5	Zostera marina	O
MUSAM\|EnsemblGenome=Ma10_g16540\|UniProtKB=A0A804KX02	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma02_g22820\|UniProtKB=A0A804I5U2	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_016949mg\|UniProtKB=K3YRQ5	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G023900\|UniProtKB=C5XT62	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb208760\|UniProtKB=B4FG11	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb230780\|UniProtKB=C4JBG7	Zea mays	O
ORYSJ\|EnsemblGenome=Os02g0125100\|UniProtKB=Q6Z702	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g02487v3\|UniProtKB=I1HWP9	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0551180\|UniProtKB=F2DK00	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2B02G181900\|UniProtKB=A0A3B6C216	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G108100\|UniProtKB=A0A3B6PIZ5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G080600\|UniProtKB=A0A3B6NLL1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G074300\|UniProtKB=A0A3B6QCE1	Triticum aestivum	O
NELNU\|Gene=LOC104602875\|UniProtKB=A0A1U8Q825	Nelumbo nucifera	O
NELNU\|Gene_ORFName=HUJ06_007528\|UniProtKB=A0A1U8AAZ6	Nelumbo nucifera	O
SPIOL\|Gene=LOC110794276\|UniProtKB=A0A9R0IV99	Spinacia oleracea	O
SPIOL\|Gene=LOC110793127\|UniProtKB=A0A9R0K084	Spinacia oleracea	O
SPIOL\|Gene=LOC110782681\|UniProtKB=A0A9R0I4Z3	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0633431\|UniProtKB=A0A251SF36	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr14g0633421\|UniProtKB=A0A251SF46	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C200064740\|UniProtKB=A0A9R1XX38	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0034671\|UniProtKB=A0A251VQU5	Helianthus annuus	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a003928mg\|UniProtKB=A0A022RUV0	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_07765\|UniProtKB=A0A2G2ZUK5	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc09g090900.3\|UniProtKB=A0A3Q7I8Z3	Solanum lycopersicum	O
CAPAN\|EnsemblGenome=T459_11793\|UniProtKB=A0A2G2ZMX6	Capsicum annuum	O
CAPAN\|EnsemblGenome=T459_11115\|UniProtKB=A0A2G2ZL09	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400013459\|UniProtKB=M1B1N3	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g005730.3\|UniProtKB=A0A3Q7FF30	Solanum lycopersicum	O
TOBAC\|Gene=LOC107796306\|UniProtKB=A0A1S4AD64	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788625\|UniProtKB=A0A1S3ZNG4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788624\|UniProtKB=A0A1S3ZN66	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi05g00839\|UniProtKB=D7SZP6	Vitis vinifera	O
VITVI\|Gene_OrderedLocusName=VIT_08s0056g01640\|UniProtKB=F6HMP3	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_H02913\|UniProtKB=A0A059B1S7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_C04P42460.1\|UniProtKB=A0A078IB26	Brassica napus	O
BRACM\|EnsemblGenome=Bra032708\|UniProtKB=M4EV75	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C08P08140.1\|UniProtKB=A0A078IWJ5	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00077191001\|UniProtKB=A0A078I3L6	Brassica napus	O
BRACM\|EnsemblGenome=Bra040341\|UniProtKB=M4FGW3	Brassica campestris	O
ARATH\|TAIR=locus=2142120\|UniProtKB=Q94AR8	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107891890\|UniProtKB=A0A1U8I250	Gossypium hirsutum	O
GOSHI\|Gene=LOC107888895\|UniProtKB=A0A1U8HRM6	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_021013\|UniProtKB=A0A061EN00	Theobroma cacao	O
GOSHI\|Gene=LOC107929168\|UniProtKB=A0A1U8LN41	Gossypium hirsutum	O
GOSHI\|Gene=LOC107930430\|UniProtKB=A0A1U8LWG0	Gossypium hirsutum	O
GOSHI\|Gene=LOC107888894\|UniProtKB=A0A1U8HZ40	Gossypium hirsutum	O
GOSHI\|Gene=LOC107891889\|UniProtKB=A0A1U8I955	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_021015\|UniProtKB=A0A061EPD6	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g010403mg\|UniProtKB=A0A067DCL7	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_008G172500v3\|UniProtKB=A0A2K1ZIT7	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_010G065100v3\|UniProtKB=B9HSU8	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_03G158200\|UniProtKB=A0A2C9W9D9	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1217320\|UniProtKB=B9SQS6	Ricinus communis	O
MANES\|EnsemblGenome=MANES_03G158100\|UniProtKB=A0A2C9WAE1	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G046300\|UniProtKB=A0A2C9UCX7	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1217310\|UniProtKB=B9SQS5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_20G199600\|UniProtKB=A0A0R0EPY9	Glycine max	O
MEDTR\|EnsemblGenome=MTR_1g073200\|UniProtKB=G7I2P7	Medicago truncatula	O
SOYBN\|EnsemblGenome=GLYMA_17G256100\|UniProtKB=K7MP05	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_14G217300\|UniProtKB=A0A0R0GG96	Glycine max	O
MEDTR\|EnsemblGenome=MTR_1g045750\|UniProtKB=G7I6Q7	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr07_22280\|UniProtKB=A0A2I4EL26	Juglans regia	O
JUGRE\|EnsemblGenome=Jr12_13970\|UniProtKB=A0A2I4DKK5	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G912340\|UniProtKB=A0A0A0LEJ4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G049300\|UniProtKB=M5XSL7	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_421784\|UniProtKB=D8SGC5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_268577\|UniProtKB=D8SGC9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_439578\|UniProtKB=D8R661	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c4_11270\|UniProtKB=A9TGU1	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0081s0061\|UniProtKB=A0A2R6WKE8	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_006670010\|UniProtKB=A0A0U9HKR2	Klebsormidium nitens	O
NITMS\|EnsemblGenome=Nmar_0420\|UniProtKB=A9A5B7	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_0972\|UniProtKB=B1L5I9	Korarchaeum cryptofilum	O
KORCO\|EnsemblGenome=Kcr_0192\|UniProtKB=B1L3C3	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO2471\|UniProtKB=Q97VY2	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1984\|UniProtKB=Q8ZW41	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_1393\|UniProtKB=Q8TQZ3	Methanosarcina acetivorans	LDO
CHLAA\|EnsemblGenome=Caur_0329\|UniProtKB=A9WD11	Chloroflexus aurantiacus	O
DEIRA\|EnsemblGenome=DR_1610\|UniProtKB=Q9RTY9	Deinococcus radiodurans	O
THEMA\|EnsemblGenome=TM_0291\|UniProtKB=Q9WYC7	Thermotoga maritima	O
DICTD\|EnsemblGenome=Dtur_1630\|UniProtKB=B8E2Q9	Dictyoglomus turgidum	O
THEMA\|EnsemblGenome=TM_0554\|UniProtKB=Q9WZ24	Thermotoga maritima	O
DEIRA\|EnsemblGenome=DR_1778\|UniProtKB=Q9RTI6	Deinococcus radiodurans	O
AQUAE\|EnsemblGenome=aq_940\|UniProtKB=O67078	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0867\|UniProtKB=B5YKE0	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_1191\|UniProtKB=B8E2X0	Dictyoglomus turgidum	O
GEOSL\|EnsemblGenome=GSU1903\|UniProtKB=Q74BX5	Geobacter sulfurreducens	O