PANTHER Gene Information

Gene Symbol(s):

ncx-4

Organism:

Caenorhabditis elegans

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Gene Name:

Sodium_calcium exchanger membrane region domain-containing protein

Gene ID:

WBGene00003569

Protein ID:

P90858

Persistent Id:

PTN000091157

Alternate Ids:

NM_001047198(refSeq)	WBGene00003569(Ensembl)
BX284601(EMBL)	14530453(GI)
F35C12.2a(WormBase_TRS)	P90858(Synonym)
CAB03047(EMBL-CDS)	CE28020(WormBase_PRO)
172834(GeneID)	P90858_CAEEL(UniProtKB-ID)
WBGene00003569(WormBase)
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PANTHER Classification

PANTHER Family:	SODIUM/POTASSIUM/CALCIUM EXCHANGER (PTHR10846)
PANTHER Subfamily:	SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN (PTHR10846:SF69)
PANTHER GO-slim Molecular Function:	sodium ion transmembrane transporter activity potassium ion transmembrane transporter activity calcium channel activity active monoatomic ion transmembrane transporter activity antiporter activity
PANTHER GO-slim Biological Process:	calcium ion transmembrane transport intracellular calcium ion homeostasis
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	secondary carrier transporter

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	antiporter activity, calcium channel activity, calcium, potassium:sodium antiporter activity
GO BP Complete:	transmembrane transport, potassium ion transmembrane transport, calcium ion transport, calcium ion transmembrane transport, sodium ion transmembrane transport, intracellular calcium ion homeostasis
GO CC Complete:	membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Transport of inorganic cations/anions and amino acids/oligopeptides, Transport of small molecules, Sodium/Calcium exchangers, SLC-mediated transmembrane transport

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10975\|UniProtKB=O60721	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000007185.7\|UniProtKB=H2Q9M6	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000016389.3\|UniProtKB=A0A2I2YTU1	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022059.4\|UniProtKB=F7HR20	Macaca mulatta	O
MOUSE\|MGI=MGI=2384871\|UniProtKB=Q91WD8	Mus musculus	O
RAT\|RGD=620080\|UniProtKB=Q9QZM6	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000025826.4\|UniProtKB=A0A3Q1M073	Bos taurus	O
BOVIN\|Gene=SLC24A1\|UniProtKB=Q28139	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000004937.5\|UniProtKB=A0A287AJV0	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000013327.4\|UniProtKB=F7BCK3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000008693.6\|UniProtKB=A0A2I2U1R2	Felis catus	O
MONDO\|Ensembl=ENSMODG00000009861.6\|UniProtKB=F6VVA1	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000043682.1\|UniProtKB=A0A6I8NKH4	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010017819.1\|UniProtKB=A0A8V0Z4V4	Gallus gallus	O
CHICK\|Gene=SLC24A1\|UniProtKB=Q9IAL8	Gallus gallus	O
XENLA\|Gene=LOC108712804\|UniProtKB=A0A1L8GSC7	Xenopus laevis	O
XENLA\|Gene=LOC108711497\|UniProtKB=A0A1L8H152	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-991430\|UniProtKB=A0A6I8RLU8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000025324.1\|UniProtKB=A0A3B3H5E6	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000007029.2\|UniProtKB=H2LRX6	Oryzias latipes	O
DANRE\|Gene=slc24a1\|UniProtKB=A0A8M3AJK7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000013820.1\|UniProtKB=W5N8T1	lepisosteus oculatus	O
HUMAN\|HGNC=10976\|UniProtKB=Q9UI40	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000020806.4\|UniProtKB=H2QX18	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000016544.3\|UniProtKB=G3RK82	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000020651.4\|UniProtKB=H9FSI4	Macaca mulatta	O
MOUSE\|MGI=MGI=1923626\|UniProtKB=Q8BUN9	Mus musculus	O
RAT\|RGD=628650\|UniProtKB=O54701	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000043972.3\|UniProtKB=E1BM98	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005167.5\|UniProtKB=F1SNG2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000020101.3\|UniProtKB=F7E0G7	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000010086.6\|UniProtKB=A0A5F5XJB0	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845014662.1\|UniProtKB=A0A8I3NPM6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000003525.4\|UniProtKB=A0A5F8GD32	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000012398.2\|UniProtKB=A0A6I8N4S2	Ornithorhynchus anatinus	O
CHICK\|Gene=SLC24A2\|UniProtKB=Q9IAL7	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010016336.1\|UniProtKB=A0A1L1RQA3	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000017625.4\|UniProtKB=G1KU78	Anolis carolinensis	O
XENLA\|Gene=LOC108706932\|UniProtKB=A0A8J1M2U2	Xenopus laevis	O
XENLA\|Gene=LOC108695376\|UniProtKB=A0A1L8HY64	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-483618\|UniProtKB=F6Z301	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000020813.2\|UniProtKB=H2N2T3	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000004872.2\|UniProtKB=A0A3B3HZ44	Oryzias latipes	O
DANRE\|Gene=slc24a2\|UniProtKB=A0A8M6YXT0	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000011046.1\|UniProtKB=W5MYV6	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000024440.1\|UniProtKB=H2Y2I8	Ciona intestinalis	O
BRAFL\|Gene=LOC118409798\|UniProtKB=A0A9J7KMZ3	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582498\|UniProtKB=A0A7M7RFU6	Strongylocentrotus purpuratus	O
CAEBR\|Gene_ORFName=CBG03868\|UniProtKB=A8WWY5	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00096083\|UniProtKB=A0A8R1YAY5	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0028704\|UniProtKB=Q9U6A0	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP029241\|UniProtKB=A0A3F2YYY2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010208\|UniProtKB=D6WTN1	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_10542\|UniProtKB=E9HDA8	Daphnia pulex	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g206699\|UniProtKB=A7S4I7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG63252\|UniProtKB=B3RSG1	Trichoplax adhaerens	O
ENTH1\|EnsemblGenome=CL6EHI_018640\|UniProtKB=C4MA70	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_049410\|UniProtKB=C4LUE3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_049310\|UniProtKB=C4LUD3	Entamoeba histolytica	O
PARTE\|EnsemblGenome=GSPATT00007604001\|UniProtKB=A0CH97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014844001\|UniProtKB=A0DA70	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_4973\|UniProtKB=B8C1L5	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_10292\|UniProtKB=B8CDR0	Thalassiosira pseudonana	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd1662\|UniProtKB=B8LEG5	Thalassiosira pseudonana	O
NITMS\|EnsemblGenome=Nmar_0590\|UniProtKB=A9A357	Nitrosopumilus maritimus	O
SACS2\|EnsemblGenome=SSO1174\|UniProtKB=Q97YX8	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO3192\|UniProtKB=Q97U31	Sulfolobus solfataricus	O
METAC\|EnsemblGenome=MA_2817\|UniProtKB=Q8TM51	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3021\|UniProtKB=Q8TLL5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2008\|UniProtKB=Q8TPA6	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0091\|UniProtKB=Q57556	Methanocaldococcus jannaschii	O
HALSA\|EnsemblGenome=VNG_2257G\|UniProtKB=Q9HN44	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_0380G\|UniProtKB=Q9HS69	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0867\|UniProtKB=Q5JI20	Thermococcus kodakaraensis	O
CHLAA\|EnsemblGenome=Caur_1857\|UniProtKB=A9WDA7	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2211\|UniProtKB=A9WFS0	Chloroflexus aurantiacus	O
THEMA\|EnsemblGenome=TM_0724\|UniProtKB=Q9WZI3	Thermotoga maritima	O
SYNY3\|Gene=P72945_SYNY3\|UniProtKB=P72945	Synechocystis	O
BACTN\|EnsemblGenome=BT_3019\|UniProtKB=Q8A3D5	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB1641\|UniProtKB=Q7UX07	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_066\|UniProtKB=O66480	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0130\|UniProtKB=B5YHF9	Thermodesulfovibrio yellowstonii	O
COXBU\|EnsemblGenome=CBU_0095\|UniProtKB=Q83F54	Coxiella burnetii	O
SHEON\|Gene_OrderedLocusName=SO_0354\|UniProtKB=Q8EJV2	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2522\|UniProtKB=Q9KP54	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM3314\|UniProtKB=Q8ZLS2	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO3576\|UniProtKB=A0A2U2H2F5	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77240\|UniProtKB=P45394	Escherichia coli	O