PANTHER Gene Information

Gene Symbol(s):

oplA

Organism:

Mycobacterium tuberculosis

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Gene Name:

Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (Pyroglutamase) (5-OPASE)

Gene ID:

Rv0266c

Protein ID:

P95223

Persistent Id:

PTN001684704

Alternate Ids:

P95223_MYCTU(UniProtKB-ID)	886642(GeneID)
15607407(GI)	NC_000962(refSeq)
AL123456(EMBL)	CCP42995(EMBL-CDS)
P95223(Synonym)
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PANTHER Classification

PANTHER Family:	5-OXOPROLINASE RELATED (PTHR11365)
PANTHER Subfamily:	HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED (PTHR11365:SF23)
PANTHER GO-slim Molecular Function:	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PANTHER GO-slim Biological Process:	glutathione metabolic process
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	hydrolase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	5-oxoprolinase (ATP-hydrolyzing) activity, hydrolase activity
GO BP Complete:	glutathione metabolic process
GO CC Complete:	cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
BATDJ\|Gene_ORFName=BATDEDRAFT_93220\|UniProtKB=F4PFS5	Batrachochytrium dendrobatidis	LDO
SACS2\|EnsemblGenome=SSO1671\|UniProtKB=Q97XP2	Sulfolobus solfataricus	O
SACS2\|EnsemblGenome=SSO1667\|UniProtKB=Q97XP4	Sulfolobus solfataricus	LDO
HUMAN\|HGNC=8149\|UniProtKB=O14841	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000020676.7\|UniProtKB=H2R0H4	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000015998.3\|UniProtKB=G3RIV3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004009.4\|UniProtKB=A0A5F8ARZ5	Macaca mulatta	O
MOUSE\|MGI=MGI=1922725\|UniProtKB=Q8K010	Mus musculus	O
RAT\|RGD=620956\|UniProtKB=P97608	Rattus norvegicus	O
BOVIN\|Gene=OPLAH\|UniProtKB=Q75WB5	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000017281.5\|UniProtKB=A0A3Q1MC53	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005911.5\|UniProtKB=F1RSN3	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000012059.4\|UniProtKB=A0A9L0RMX3	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000011543.6\|UniProtKB=M3WFA2	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845007462.1\|UniProtKB=A0A8I3MWT8	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000010431.4\|UniProtKB=F6YTL4	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000015139.3\|UniProtKB=F6WVB6	Ornithorhynchus anatinus	O
XENLA\|Gene=LOC108719484\|UniProtKB=A0A8J0VLS5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5886065\|UniProtKB=A0JM10	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000007364.2\|UniProtKB=H2LT15	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-121214-293\|UniProtKB=E7F6Z6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008846.1\|UniProtKB=W5MQX0	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000009509.3\|UniProtKB=F6XJM1	Ciona intestinalis	O
BRAFL\|Gene=LOC118417030\|UniProtKB=A0A9J7LAB1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC589767\|UniProtKB=A0A7M7N7B9	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00021430\|UniProtKB=A0A9S2	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16813\|UniProtKB=A8XPV1	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00305216\|UniProtKB=A0A8R1V6R3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0034733\|UniProtKB=Q9W247	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001606\|UniProtKB=Q8T5H1	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC009532\|UniProtKB=D6WSA5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304866\|UniProtKB=E9GMC6	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG105203\|UniProtKB=T1EDR6	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG30232\|UniProtKB=B3S6Q0	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_15677\|UniProtKB=A9UUD3	Monosiga brevicollis	O
EMENI\|EnsemblGenome=ANIA_08779\|UniProtKB=Q5ASF1	Emericella nidulans	O
CRYNJ\|EnsemblGenome=CNE00950\|UniProtKB=Q5KH79	Cryptococcus neoformans	O
YEAST\|SGD=S000001698\|UniProtKB=P28273	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ABR114C\|UniProtKB=Q75DB0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000190727\|UniProtKB=A0A1D8PGR6	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E02398g\|UniProtKB=Q6C7A4	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_05652\|UniProtKB=Q5B1C8	Emericella nidulans	O
PHANO\|Gene_ORFName=SNOG_08798\|UniProtKB=Q0UHG6	Phaeosphaeria nodorum	O
EMENI\|EnsemblGenome=ANIA_03972\|UniProtKB=Q5B658	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G14330\|UniProtKB=Q4WL95	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU04569\|UniProtKB=V5INS7	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_10595\|UniProtKB=A7EZ29	Sclerotinia sclerotiorum	O
PHANO\|Gene_ORFName=SNOG_04179\|UniProtKB=Q0UVN5	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_09512\|UniProtKB=Q0UFF2	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC11D3.14c\|UniProtKB=Q10093	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPAC11D3.15\|UniProtKB=Q10094	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_01995\|UniProtKB=B6JZF7	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNC02650\|UniProtKB=Q5KKL0	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNE05310\|UniProtKB=Q5KG06	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_03902\|UniProtKB=A0A0D1DZ67	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_01119\|UniProtKB=E3JUR3	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_12136\|UniProtKB=F4P3Z7	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0284953\|UniProtKB=Q54NW6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_50323\|UniProtKB=F0ZXZ7	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_18_1040\|UniProtKB=Q4QDT8	Leishmania major	O
PARTE\|EnsemblGenome=GSPATT00014285001\|UniProtKB=A0D8H2	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_21538\|UniProtKB=B8BVU8	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H6J5_PHYRM\|UniProtKB=H3H6J5	Phytophthora ramorum	O
PHYRM\|Gene=H3GAQ5_PHYRM\|UniProtKB=H3GAQ5	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_07g325748v5\|UniProtKB=A0A2K3DJF9	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00012p00060770\|UniProtKB=W1PKU4	Amborella trichopoda	O
AMBTC\|EnsemblGenome=AMTR_s00012p00059980\|UniProtKB=W1PJ36	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_154G00200\|UniProtKB=A0A0K9PVM1	Zostera marina	O
MUSAM\|EnsemblGenome=Ma09_g03990\|UniProtKB=A0A804KFR8	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_039681mg\|UniProtKB=K4ALA1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G322700\|UniProtKB=C5WUM9	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb021240\|UniProtKB=A0A1D6K6V8	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0966000\|UniProtKB=Q8LHD1	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g31390v3\|UniProtKB=I1I5H1	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0615590\|UniProtKB=A0A8I6YDP8	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6A02G308800\|UniProtKB=A0A3B6NSA9	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G337600\|UniProtKB=A0A3B6PQH4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6D02G288100\|UniProtKB=A0A3B6QI83	Triticum aestivum	O
NELNU\|Gene=LOC104599210\|UniProtKB=A0A1U8ACR3	Nelumbo nucifera	O
SPIOL\|Gene=LOC110793468\|UniProtKB=A0A9R0K0L2	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr07g0284671\|UniProtKB=A0A251TQ51	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C600303490\|UniProtKB=A0A9R1X6W4	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a000298mg\|UniProtKB=A0A022QYQ8	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_22892\|UniProtKB=A0A2G2YQS3	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400008847\|UniProtKB=M1AH87	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc09g010560.2\|UniProtKB=A0A3Q7HY45	Solanum lycopersicum	O
TOBAC\|Gene=LOC107803589\|UniProtKB=A0A1S4B1K7	Nicotiana tabacum	O
TOBAC\|Gene=LOC107781908\|UniProtKB=A0A1S3Z195	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi08g01177\|UniProtKB=F6HLE2	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_I01066\|UniProtKB=A0A059AMN2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00036796001\|UniProtKB=A0A078GNY0	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00088380001\|UniProtKB=A0A078IAF9	Brassica napus	O
BRACM\|EnsemblGenome=Bra028393\|UniProtKB=M4EHX8	Brassica campestris	O
ARATH\|TAIR=locus=2156030\|UniProtKB=Q9FIZ7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107886869\|UniProtKB=A0A1U8HK73	Gossypium hirsutum	O
GOSHI\|Gene=LOC107909008\|UniProtKB=A0A1U8JNL4	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_007670\|UniProtKB=A0A061E1X5	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g000831mg\|UniProtKB=A0A067DWX4	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_017G124400v3\|UniProtKB=A0A2K1X724	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G091000v3\|UniProtKB=A0A2K2AS18	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_11G123000\|UniProtKB=A0A2C9V0T3	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1248770\|UniProtKB=B9SP24	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_08G069400\|UniProtKB=I1KQZ7	Glycine max	O
MEDTR\|EnsemblGenome=MTR_4g093870\|UniProtKB=G7JV66	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr04_04820\|UniProtKB=A0A2I4HPJ6	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G000060\|UniProtKB=A0A0A0KCV4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_2G098100\|UniProtKB=M5X2E6	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_98098\|UniProtKB=D8RP34	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_136983\|UniProtKB=D8TCQ6	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c19_22940\|UniProtKB=A0A7I4BP05	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0035s0055\|UniProtKB=A0A2R6X585	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_007520030\|UniProtKB=A0A1Y1IM99	Klebsormidium nitens	O
SACS2\|EnsemblGenome=SSO1663\|UniProtKB=Q97XP8	Sulfolobus solfataricus	O
METAC\|EnsemblGenome=MA_4396\|UniProtKB=Q8THW5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_0858\|UniProtKB=Q8TSE0	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_4563\|UniProtKB=Q8THF4	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_4203\|UniProtKB=Q8TIE9	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3497\|UniProtKB=Q8TKB3	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_4562\|UniProtKB=Q8THF5	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_4395\|UniProtKB=Q8THW6	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_3498\|UniProtKB=Q8TKB2	Methanosarcina acetivorans	O
METAC\|EnsemblGenome=MA_2889\|UniProtKB=Q8TLY3	Methanosarcina acetivorans	O
CHLAA\|EnsemblGenome=Caur_2264\|UniProtKB=A9WGE1	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO0627\|UniProtKB=Q9RD55	Streptomyces coelicolor	LDO
GLOVI\|Gene=Q7NIT4_GLOVI\|UniProtKB=Q7NIT4	Gloeobacter violaceus	LDO
SYNY3\|Gene=Q55959_SYNY3\|UniProtKB=Q55959	Synechocystis	LDO
RHOBA\|EnsemblGenome=RB8038\|UniProtKB=Q7UG95	Rhodopirellula baltica	LDO
AQUAE\|EnsemblGenome=aq_708\|UniProtKB=O66925	Aquifex aeolicus	LDO
HELPY\|EnsemblGenome=HP_0696\|UniProtKB=O25403	Helicobacter pylori	O
HELPY\|EnsemblGenome=HP_0695\|UniProtKB=O25402	Helicobacter pylori	LDO
BRADU\|Gene=Q89P62_BRADU\|UniProtKB=Q89P62	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89Q04_BRADU\|UniProtKB=Q89Q04	Bradyrhizobium diazoefficiens	LDO
BRADU\|Gene=Q89EA7_BRADU\|UniProtKB=Q89EA7	Bradyrhizobium diazoefficiens	O