PANTHER Gene Information

Gene Symbol(s):

metB

Organism:

Mycobacterium tuberculosis

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Gene Name:

Cystathionine gamma-synthase

Gene ID:

Rv1079

Protein ID:

P9WGB7

Persistent Id:

PTN002273782

Alternate Ids:

45425051(GeneID)	614092913(GI)
metB(Symbol)	O-succinylhomoserine (thiol)-lyase(Synonym)
CCP43830(EMBL-CDS)	AL123456(EMBL)
WP_003405736(refSeq)	2.5.1.48(EC)
METB_MYCTU(UniProtKB-ID)	L0T5M9(AltAccession)
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PANTHER Classification

PANTHER Family:	TRANS-SULFURATION ENZYME FAMILY MEMBER (PTHR11808)
PANTHER Subfamily:	CYSTATHIONINE GAMMA-LYASE (PTHR11808:SF15)
PANTHER GO-slim Molecular Function:	organic cyclic compound binding lyase activity heterocyclic compound binding anion binding
PANTHER GO-slim Biological Process:	L-amino acid biosynthetic process sulfur compound metabolic process proteinogenic amino acid biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	lyase

Pathway Categories:

Methionine biosynthesis

O-Succinyl homoserine lyase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	cystathionine gamma-synthase activity, pyridoxal phosphate binding, transferase activity, cystathionine gamma-lyase activity
GO BP Complete:	methionine biosynthetic process, cysteine biosynthetic process via cystathionine, transsulfuration, L-methionine biosynthetic process from L-homoserine via cystathionine
GO CC Complete:	cytoplasm, cytosol, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Sulfur amino acid metabolism, Mycobacterium tuberculosis biological processes, Sulfur compound metabolism

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2501\|UniProtKB=P32929	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000854.3\|UniProtKB=H2PZ82	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016539.3\|UniProtKB=G3RK81	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000019326.4\|UniProtKB=G7MHK1	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1339968\|UniProtKB=Q8VCN5	Mus musculus	LDO
RAT\|RGD=2443\|UniProtKB=P18757	Rattus norvegicus	LDO
BOVIN\|Gene=CTH\|UniProtKB=Q58DW2	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000014791.6\|UniProtKB=B0JYP8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000004415.4\|UniProtKB=A0A3Q1M2L1	Bos taurus	LDO
PIG\|Gene=CTH\|UniProtKB=Q19QT7	Sus scrofa	LDO
PIG\|Ensembl=ENSSSCG00005011808.1\|UniProtKB=A0A8D0UYT1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015050.4\|UniProtKB=A0A9L0TA00	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000012450.6\|UniProtKB=M3WGZ1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845012905.1\|UniProtKB=A0A8I3NI47	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000015532.4\|UniProtKB=F6W6K6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023888.1\|UniProtKB=E1BYF1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000013510.4\|UniProtKB=H9GK11	Anolis carolinensis	LDO
XENLA\|Gene=cth.S\|UniProtKB=A0A8J1MZW4	Xenopus laevis	O
XENLA\|Gene=cth.L\|UniProtKB=Q640H4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5784449\|UniProtKB=Q6P849	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007779.2\|UniProtKB=H2LUG7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040905-3\|UniProtKB=Q68EI1	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-030131-774\|UniProtKB=F1QPF7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010025.1\|UniProtKB=W5MV56	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118431995\|UniProtKB=A0A9J7NCF2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC762952\|UniProtKB=A0A7M7T3P0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00009048\|UniProtKB=O45391	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00022856\|UniProtKB=P55216	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00042787\|UniProtKB=A8WLD9	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00273954\|UniProtKB=A0A2A6B752	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0000566\|UniProtKB=Q7JXZ2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP011172\|UniProtKB=Q7QHF8	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC012563\|UniProtKB=D6X383	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_304533\|UniProtKB=E9HUP6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119078\|UniProtKB=E9HXC8	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_306997\|UniProtKB=E9HXC9	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG185538\|UniProtKB=T1FMY1	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG156911\|UniProtKB=T1EM31	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG111430\|UniProtKB=T1EFB3	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g184363\|UniProtKB=A7S143	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG64137\|UniProtKB=B3S3V3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG36312\|UniProtKB=B3S3W7	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_12618\|UniProtKB=A9VCT5	Monosiga brevicollis	LDO
YEAST\|SGD=S000001154\|UniProtKB=P38716	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AER250C\|UniProtKB=Q756K4	Eremothecium gossypii	O
CANAL\|CGD=CAL0000185607\|UniProtKB=A0A1D8PTV7	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_C22088g\|UniProtKB=Q6CB42	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00681\|UniProtKB=Q5BFJ9	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G13810\|UniProtKB=Q4WVZ1	Neosartorya fumigata	O
EMENI\|EnsemblGenome=ANIA_11168\|UniProtKB=C8VK55	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_3G01170\|UniProtKB=Q4WFS7	Neosartorya fumigata	O
ASPFU\|EnsemblGenome=AFUA_7G01590\|UniProtKB=Q4WAK1	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00522\|UniProtKB=Q7SCL5	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_04225\|UniProtKB=A7EFY4	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_00049\|UniProtKB=Q0V7G5	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC23A1.14c\|UniProtKB=O42851	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02205\|UniProtKB=B6K1U3	Schizosaccharomyces japonicus	O
USTMA\|EnsemblGenome=UMAG_11720\|UniProtKB=A0A0D1CS52	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_15188\|UniProtKB=E3KXB2	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_84873\|UniProtKB=F4NRF0	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_84903\|UniProtKB=F4NRQ4	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15036\|UniProtKB=F4PF63	Batrachochytrium dendrobatidis	O
YEAST\|SGD=S000000010\|UniProtKB=P31373	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AEL341W\|UniProtKB=Q758U3	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000178125\|UniProtKB=Q5A362	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F05874g\|UniProtKB=Q6C2Q9	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_01446\|UniProtKB=C8VM61	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_8G04340\|UniProtKB=Q4WCI1	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU09230\|UniProtKB=Q1K900	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_01702\|UniProtKB=A7E8S4	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15232\|UniProtKB=Q0TZA5	Phaeosphaeria nodorum	LDO
CRYNJ\|EnsemblGenome=CNN01730\|UniProtKB=Q5K6Y9	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10589\|UniProtKB=A0A0D1E9J0	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_06587\|UniProtKB=E3K8Q0	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_34425\|UniProtKB=F4NW75	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0269122\|UniProtKB=Q55DV9	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_147848\|UniProtKB=F0Z9K3	Dictyostelium purpureum	LDO
PARTE\|EnsemblGenome=GSPATT00024749001\|UniProtKB=A0E9Q1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013229001\|UniProtKB=A0D3Z7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029327001\|UniProtKB=A0BJI2	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_269520\|UniProtKB=B8C9L7	Thalassiosira pseudonana	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_11993\|UniProtKB=B8CG57	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GAC3_PHYRM\|UniProtKB=H3GAC3	Phytophthora ramorum	LDO
KORCO\|EnsemblGenome=Kcr_0985\|UniProtKB=B1L5K2	Korarchaeum cryptofilum	LDO
PYRAE\|EnsemblGenome=PAE2420\|UniProtKB=Q8ZV75	Pyrobaculum aerophilum	LDO
HALSA\|EnsemblGenome=VNG_0796G\|UniProtKB=Q9HR98	Halobacterium salinarum	LDO
THEKO\|EnsemblGenome=TK1449\|UniProtKB=Q5JH48	Thermococcus kodakaraensis	LDO
CHLAA\|EnsemblGenome=Caur_1877\|UniProtKB=A9WDC6	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO4958\|UniProtKB=Q9EWF9	Streptomyces coelicolor	LDO
CLOBH\|Gene_OrderedLocusName=CBO0726\|UniProtKB=A5HZR9	Clostridium botulinum	LDO
STAA8\|EnsemblGenome=SAOUHSC_00422\|UniProtKB=Q2G0V3	Staphylococcus aureus	LDO
BACSU\|EnsemblGenome=BSU_27250\|UniProtKB=O05394	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_4366\|UniProtKB=Q818A3	Bacillus cereus	LDO
RHOBA\|EnsemblGenome=RB6443\|UniProtKB=Q7UQ99	Rhodopirellula baltica	LDO
HELPY\|EnsemblGenome=HP_0106\|UniProtKB=P56069	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB0802\|UniProtKB=Q9K024	Neisseria meningitidis serogroup b	LDO
SHEON\|Gene_OrderedLocusName=SO_4056\|UniProtKB=Q8EA53	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2683\|UniProtKB=Q9KNP8	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC2856\|UniProtKB=Q8P6V9	Xanthomonas campestris	O
SALTY\|EnsemblGenome=STM4100\|UniProtKB=Q8ZKN5	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAE77371\|UniProtKB=P00935	Escherichia coli	O
COXBU\|EnsemblGenome=CBU_2025\|UniProtKB=Q83A83	Coxiella burnetii	LDO
XANCP\|EnsemblGenome=XCC0598\|UniProtKB=Q8PCV4	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA0400\|UniProtKB=Q9I6A0	Pseudomonas aeruginosa	LDO