PANTHER Gene Information

Gene Symbol(s):

pyrD

Organism:

Mycobacterium tuberculosis

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Gene Name:

Dihydroorotate dehydrogenase (quinone)

Gene ID:

Rv2139

Protein ID:

P9WHL1

Persistent Id:

PTN002460750

Alternate Ids:

1.3.5.2(EC)	O06236(AltAccession)
CCP44914(EMBL-CDS)	15609276(GI)
pyrD(Symbol)	AL123456(EMBL)
887326(GeneID)	WP_003411116(refSeq)
PYRD_MYCTU(UniProtKB-ID)	DHOD(Synonym)
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PANTHER Classification

PANTHER Family:	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED (PTHR48109)
PANTHER Subfamily:	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (PTHR48109:SF4)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on the CH-CH group of donors
PANTHER GO-slim Biological Process:	pyrimidine nucleotide metabolic process ribonucleotide biosynthetic process organonitrogen compound biosynthetic process pyrimidine nucleobase metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

De novo pyrimidine ribonucleotides biosythesis

Dihydrooratate oxidase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	oxidoreductase activity, dihydroorotate dehydrogenase activity, dihydroorotate dehydrogenase (quinone) activity
GO BP Complete:	'de novo' pyrimidine nucleobase biosynthetic process, pyrimidine ribonucleotide biosynthetic process, pyrimidine nucleotide biosynthetic process, 'de novo' UMP biosynthetic process
GO CC Complete:	cytoplasm, membrane, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=2867\|UniProtKB=Q02127	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000008333.7\|UniProtKB=H2QBH6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000013030.3\|UniProtKB=G3RB74	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000023312.4\|UniProtKB=H9Z5X8	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1928378\|UniProtKB=O35435	Mus musculus	LDO
RAT\|RGD=68352\|UniProtKB=Q63707	Rattus norvegicus	LDO
BOVIN\|Gene=DHODH\|UniProtKB=Q5E9W3	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000019887.5\|UniProtKB=G8JKZ0	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002746.5\|UniProtKB=F1S3B0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000603.4\|UniProtKB=F7C5A0	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000026024.4\|UniProtKB=M3WTW7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845007968.1\|UniProtKB=A0A8I3N262	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002480.3\|UniProtKB=F7BVX3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000040364.1\|UniProtKB=A0A6I8NB65	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010008341.1\|UniProtKB=A0A8V0XXT5	Gallus gallus	LDO
XENLA\|Gene=dhodh.L\|UniProtKB=Q4QR42	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-967864\|UniProtKB=Q5BKN2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005804.2\|UniProtKB=H2LMM3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-3157\|UniProtKB=Q5PR57	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000004457.1\|UniProtKB=W5MAC5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000009392.3\|UniProtKB=F6UA87	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118417007\|UniProtKB=A0A9J7L8I3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC589543\|UniProtKB=A0A7M7RI91	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00020932\|UniProtKB=O01815	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG04047\|UniProtKB=A8WW30	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0000447\|UniProtKB=P32748	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002037\|UniProtKB=Q7PYN9	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC011160\|UniProtKB=D6X3Z9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_106454\|UniProtKB=E9GTU3	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW020699\|UniProtKB=B7PXW4	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG101454\|UniProtKB=T1ED46	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g171857\|UniProtKB=A7SLG1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG20390\|UniProtKB=B3RIP0	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_39284\|UniProtKB=A9VDH7	Monosiga brevicollis	LDO
EREGS\|EnsemblGenome=AGOS_ACL035C\|UniProtKB=Q75CE1	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000178448\|UniProtKB=Q874I4	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D18920g\|UniProtKB=Q6C8K4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_05909\|UniProtKB=G5EB61	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G11010\|UniProtKB=Q4X169	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU06532\|UniProtKB=Q7S895	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_14024\|UniProtKB=A7F8U3	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_13574\|UniProtKB=Q0U3U0	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC57A10.12c\|UniProtKB=P32747	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00197\|UniProtKB=B6JXQ5	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNC04130\|UniProtKB=Q5KK62	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10643\|UniProtKB=A0A0D1DYC9	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16739\|UniProtKB=E3L2C6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_84444\|UniProtKB=F4NRB1	Batrachochytrium dendrobatidis	LDO
PLAF7\|EnsemblGenome=PF3D7_0603300\|UniProtKB=Q08210	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00019604001\|UniProtKB=A0DS83	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_264316\|UniProtKB=B8CDH4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GAQ0_PHYRM\|UniProtKB=H3GAQ0	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_03g199423v5\|UniProtKB=A0A2K3DZJ5	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00029p00035480\|UniProtKB=W1PMV7	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_259G00220\|UniProtKB=A0A0K9PHS9	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma03_g00090\|UniProtKB=A0A804I6S8	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_024874mg\|UniProtKB=K3ZE81	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3006G266200\|UniProtKB=A0A1Z5RFU2	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb433680\|UniProtKB=A0A804RM97	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os04g0676300\|UniProtKB=Q7XKC8	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_5g26080v3\|UniProtKB=I1J3B8	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0210270\|UniProtKB=A0A8I6WKM0	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2D02G559400\|UniProtKB=A0A3B6DN56	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS2B02G588900\|UniProtKB=A0A3B6CGD3	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS2A02G555100\|UniProtKB=A0A3B6B8Q6	Triticum aestivum	LDO
NELNU\|Gene=LOC104592016\|UniProtKB=A0A1U7ZDR5	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110799885\|UniProtKB=A0A9R0K705	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0028671\|UniProtKB=A0A251VPD3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr01g0028651\|UniProtKB=A0A251VRT8	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C100032910\|UniProtKB=A0A9R1WQ20	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C100032920\|UniProtKB=A0A9R1WK35	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a005993mg\|UniProtKB=A0A022RZN7	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_21139\|UniProtKB=A0A1U8E220	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG401016396\|UniProtKB=M1BCR0	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g008290.3\|UniProtKB=A0A3Q7E9S8	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107783663\|UniProtKB=A0A1S3Z6Z0	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_10s0042g00140\|UniProtKB=F6HIN2	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_I02621\|UniProtKB=A0A059AT94	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_A09P07010.1\|UniProtKB=A0A078FUY5	Brassica napus	O
BRACM\|EnsemblGenome=Bra026504\|UniProtKB=M4ECJ4	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C07P44260.1\|UniProtKB=A0A078I6K6	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra009669\|UniProtKB=A0A3P5Z6K5	Brassica campestris	LDO
ARATH\|TAIR=locus=2166943\|UniProtKB=P32746	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107909020\|UniProtKB=A0A1U8JSW6	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_007693\|UniProtKB=A0A061E9W2	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g012517mg\|UniProtKB=A0A067FR62	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_005G089700v3\|UniProtKB=B9H5P7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_15G107800\|UniProtKB=A0A2C9UF14	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0110060\|UniProtKB=B9TAL5	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_0164820\|UniProtKB=B9SLA6	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_20G103100\|UniProtKB=I1NF53	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_10G286200\|UniProtKB=I1LF90	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_1g114530\|UniProtKB=G7IEA3	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr13_20300\|UniProtKB=A0A2I4ED70	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_1G571860\|UniProtKB=A0A0A0LYK0	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_4G061300\|UniProtKB=M5WGE5	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_6G003700\|UniProtKB=M5WQA0	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_84627\|UniProtKB=D8R3V8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_440247\|UniProtKB=D8RAG3	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c15_6200\|UniProtKB=A9TQR7	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c9_12870\|UniProtKB=A0A2K1K2Z4	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0020s0155\|UniProtKB=A0A2R6XEK3	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000180090\|UniProtKB=A0A1Y1HJL1	Klebsormidium nitens	LDO
PYRAE\|EnsemblGenome=PAE3263\|UniProtKB=Q8ZTG4	Pyrobaculum aerophilum	LDO
HALSA\|EnsemblGenome=VNG_2507G\|UniProtKB=Q9HMK2	Halobacterium salinarum	LDO
CHLAA\|EnsemblGenome=Caur_3923\|UniProtKB=A9WDI1	Chloroflexus aurantiacus	LDO
STRCO\|Gene_OrderedLocusName=SCO1482\|UniProtKB=Q9KXR7	Streptomyces coelicolor	LDO
STAA8\|EnsemblGenome=SAOUHSC_02909\|UniProtKB=Q2FV30	Staphylococcus aureus	LDO
BACCR\|EnsemblGenome=BC_0511\|UniProtKB=Q81I86	Bacillus cereus	LDO
DEIRA\|EnsemblGenome=DR_0501\|UniProtKB=Q9RX14	Deinococcus radiodurans	LDO
GLOVI\|EnsemblGenome=BAC91021\|UniProtKB=Q7NC99	Gloeobacter violaceus	LDO
SYNY3\|EnsemblGenome=BAA18627\|UniProtKB=P74782	Synechocystis	LDO
LEPIN\|EnsemblGenome=LA_4290\|UniProtKB=Q8EYC6	Leptospira interrogans	LDO
BACTN\|EnsemblGenome=BT_1009\|UniProtKB=Q8A908	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB9748\|UniProtKB=Q7UL43	Rhodopirellula baltica	LDO
HELPY\|EnsemblGenome=HP_1011\|UniProtKB=O25655	Helicobacter pylori	LDO
NEIMB\|EnsemblGenome=NMB0221\|UniProtKB=Q9K1D7	Neisseria meningitidis serogroup b	LDO
COXBU\|EnsemblGenome=CBU_0971\|UniProtKB=Q83CY0	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_1401\|UniProtKB=P45477	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_2592\|UniProtKB=Q8EDZ8	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_1491\|UniProtKB=Q9KRZ2	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC1788\|UniProtKB=Q8P9R0	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA3050\|UniProtKB=Q9HZF8	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM1058\|UniProtKB=P25468	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_1178\|UniProtKB=Q8ZG91	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAA35700\|UniProtKB=P0A7E1	Escherichia coli	LDO