PANTHER Gene Information

Gene Symbol(s):

alkA

Organism:

Mycobacterium tuberculosis

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Gene Name:

Probable bifunctional transcriptional activator_DNA repair enzyme AlkA

Gene ID:

Rv1317c

Protein ID:

P9WJW3

Persistent Id:

PTN002452919

Alternate Ids:

CCP44074(EMBL-CDS)	AL123456(EMBL)
2.1.1.n11(EC)	1513196(GI)
L0T913(AltAccession)	NP_215833(refSeq)
Methylphosphotriester-DNA methyltransferase(Synonym)	ALKA_MYCTU(UniProtKB-ID)
alkA(Symbol)	886916(GeneID)
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PANTHER Classification

PANTHER Family:	DNA-3-METHYLADENINE GLYCOSYLASE (PTHR43003)
PANTHER Subfamily:	DNA-3-METHYLADENINE GLYCOSYLASE 2 (PTHR43003:SF13)
PANTHER GO-slim Molecular Function:	damaged DNA binding DNA N-glycosylase activity
PANTHER GO-slim Biological Process:	DNA modification base-excision repair
PANTHER GO-slim Cellular Component:	protein-DNA complex cytoplasm
PANTHER protein class:	DNA glycosylase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	zinc ion binding, alkylated DNA binding, DNA-7-methylguanine glycosylase activity, methyltransferase activity, sequence-specific DNA binding, DNA-5-methylcytosine glycosylase activity, DNA binding, DNA-binding transcription factor activity, DNA-3-methyladenine glycosylase activity, metal ion binding, DNA-7-methyladenine glycosylase activity, hydrolase activity, DNA-3-methylguanine glycosylase activity
GO BP Complete:	DNA alkylation repair, DNA repair, base-excision repair, base-excision repair, AP site formation, regulation of DNA-templated transcription, response to nitrosative stress, methylation
GO CC Complete:	cytoplasm, peptidoglycan-based cell wall, protein-DNA complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
YEAST\|SGD=S000000944\|UniProtKB=P22134	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFR011W\|UniProtKB=Q754R1	Eremothecium gossypii	O
CANAL\|CGD=CAL0000200044\|UniProtKB=A0A1D8PI96	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_B14080g\|UniProtKB=Q6CEP5	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_04389\|UniProtKB=Q5B4Z2	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G06800\|UniProtKB=Q4WNS6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08938\|UniProtKB=Q1K6S4	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_10574\|UniProtKB=A7EZ08	Sclerotinia sclerotiorum	O
SCHPO\|PomBase=SPBC23G7.11\|UniProtKB=O94468	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPAPB24D3.04c\|UniProtKB=Q92383	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_05257\|UniProtKB=B6K1P6	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_01971\|UniProtKB=B6JZD7	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNL04530\|UniProtKB=Q5K8T8	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00380\|UniProtKB=A0A0D1E7V8	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_14148\|UniProtKB=E3KX39	Puccinia graminis	O
CHLRE\|EnsemblGenome=CHLRE_11g476400v5\|UniProtKB=A0A2K3D8D5	Chlamydomonas reinhardtii	O
ZOSMR\|Gene_ORFName=ZOSMA_53G01060\|UniProtKB=A0A0K9NX40	Zostera marina	O
MUSAM\|EnsemblGenome=Ma07_g27090\|UniProtKB=A0A804K0D2	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma06_g23550\|UniProtKB=A0A804JJK7	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_022877mg\|UniProtKB=K3Z8K7	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3009G235300\|UniProtKB=C5YVX2	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb296180\|UniProtKB=B6U6Y8	Zea mays	O
ORYSJ\|EnsemblGenome=Os05g0567500\|UniProtKB=Q688W2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g16110v3\|UniProtKB=I1HGA3	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0089750\|UniProtKB=F2E5R4	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS1B02G435600\|UniProtKB=A0A3B5Z4U7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G405500\|UniProtKB=A0A3B5Y6V8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G413500\|UniProtKB=A0A3B6A175	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_025156mg\|UniProtKB=K3ZF07	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3009G243900\|UniProtKB=C5YWE3	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb296790\|UniProtKB=B4FZ58	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb344580\|UniProtKB=B4FHY2	Zea mays	O
ORYSJ\|EnsemblGenome=Os03g0248250\|UniProtKB=A0A0P0VVS2	Oryza sativa	O
ORYSJ\|EnsemblGenome=Os05g0579100\|UniProtKB=Q9XHW2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g14910v3\|UniProtKB=I1HFY5	Brachypodium distachyon	O
WHEAT\|EnsemblGenome=TraesCS1D02G426100\|UniProtKB=A0A3B6A1M1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G418400\|UniProtKB=A0A3B5Y846	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G448400\|UniProtKB=A0A3B5Z596	Triticum aestivum	O
NELNU\|Gene=LOC104595671\|UniProtKB=A0A1U7ZRZ9	Nelumbo nucifera	O
NELNU\|Gene=LOC104601852\|UniProtKB=A0A1U8ALR8	Nelumbo nucifera	O
SPIOL\|Gene=LOC110804801\|UniProtKB=A0A9R0JDN3	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0393741\|UniProtKB=A0A251TY92	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0775561\|UniProtKB=A0A251S3D3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0393811\|UniProtKB=A0A251TY93	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C400215230\|UniProtKB=A0A9R1XD02	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a021549mg\|UniProtKB=A0A022RMG9	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_06342\|UniProtKB=A0A2G3AAE9	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400015479\|UniProtKB=M1B955	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc02g062720.3\|UniProtKB=A0A3Q7EZD7	Solanum lycopersicum	O
TOBAC\|Gene=LOC107808573\|UniProtKB=A0A1S4BI85	Nicotiana tabacum	O
TOBAC\|Gene=LOC107788381\|UniProtKB=A0A1S3ZMN0	Nicotiana tabacum	O
TOBAC\|Gene=LOC107803104\|UniProtKB=A0A1S4B096	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_13271\|UniProtKB=A0A1U8GKC0	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc04g080470.3\|UniProtKB=A0A3Q7GBD2	Solanum lycopersicum	O
TOBAC\|Gene=LOC107789650\|UniProtKB=A0A1S3ZRP6	Nicotiana tabacum	O
TOBAC\|Gene=LOC107805378\|UniProtKB=A0A1S4B7Q3	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi03g00319\|UniProtKB=F6HQM9	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi04g01303\|UniProtKB=F6GWV9	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_H01279\|UniProtKB=A0A059AXB3	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra036853\|UniProtKB=M4F6Z3	Brassica campestris	O
ARATH\|TAIR=locus=2077947\|UniProtKB=Q9SVL1	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107909405\|UniProtKB=A0A1U8JQ45	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_000372\|UniProtKB=A0A061DG66	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g039703mg\|UniProtKB=A0A067GLL0	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_007G024200v3\|UniProtKB=B9HF10	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_02G094000\|UniProtKB=A0A251LGJ2	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0536110\|UniProtKB=B9S6F5	Ricinus communis	O
MEDTR\|EnsemblGenome=MTR_5g020300\|UniProtKB=G7KDL7	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr07_04220\|UniProtKB=A0A2I4HAD9	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G502690\|UniProtKB=A0A0A0KM62	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_7G155600\|UniProtKB=M5WA36	Prunus persica	O
EUCGR\|EnsemblGenome=EUGRSUZ_F01572\|UniProtKB=A0A059BPN3	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra003760\|UniProtKB=M4CHS7	Brassica campestris	O
ARATH\|TAIR=locus=2025127\|UniProtKB=F4HXH4	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=GSBRNA2T00067841001\|UniProtKB=A0A078HNC8	Brassica napus	O
BRANA\|Gene_ORFName=DARMORV10_A06P15650.1\|UniProtKB=A0A078GXV1	Brassica napus	O
BRACM\|EnsemblGenome=Bra025741\|UniProtKB=M4EAD3	Brassica campestris	O
ARATH\|TAIR=locus=2016457\|UniProtKB=Q0V7V4	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107961123\|UniProtKB=A0A1U8PNW7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107905434\|UniProtKB=A0A1U8JB91	Gossypium hirsutum	O
GOSHI\|Gene=LOC107904953\|UniProtKB=A0A1U8J9H6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107957572\|UniProtKB=A0A1U8PBT9	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_034050\|UniProtKB=A0A061FD01	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g039604mg\|UniProtKB=A0A067H9Y5	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_005G227700\|UniProtKB=A0A3N7EZT1	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_002G035300v3\|UniProtKB=A0A2K2BCX3	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_05G158700\|UniProtKB=A0A2C9VWS2	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_18G023800\|UniProtKB=A0A2C9U0S1	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1594450\|UniProtKB=B9R7V3	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_06G031700\|UniProtKB=I1K7R5	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G031600\|UniProtKB=I1JTA6	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g111890\|UniProtKB=A0A072V463	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr15_06770\|UniProtKB=A0A2I4EQE9	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_3G857070\|UniProtKB=A0A0A0LIY1	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G378400\|UniProtKB=A0A251RC19	Prunus persica	O
PHYPA\|EnsemblGenome=Pp3c16_1250\|UniProtKB=A0A2K1J6Q8	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c6_17700\|UniProtKB=A0A2K1KG31	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0005s0224\|UniProtKB=A0A2R6XR59	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_004590070\|UniProtKB=A0A1Y1ICV0	Klebsormidium nitens	O
METAC\|EnsemblGenome=MA_3207\|UniProtKB=Q8TL35	Methanosarcina acetivorans	O
HALSA\|EnsemblGenome=VNG_1311G\|UniProtKB=Q9HQ62	Halobacterium salinarum	O
THEKO\|EnsemblGenome=TK0345\|UniProtKB=Q5JG19	Thermococcus kodakaraensis	O
STRCO\|Gene_OrderedLocusName=SCO6150\|UniProtKB=Q9ZBT8	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO6461\|UniProtKB=Q9ZBF2	Streptomyces coelicolor	LDO
PSEAE\|EnsemblGenome=PA1686\|UniProtKB=Q9I339	Pseudomonas aeruginosa	LDO
GLOVI\|Gene=Q7NFB7_GLOVI\|UniProtKB=Q7NFB7	Gloeobacter violaceus	LDO
BRADU\|Gene=alkA\|UniProtKB=Q89UP0	Bradyrhizobium diazoefficiens	LDO
SHEON\|Gene_OrderedLocusName=SO_3127\|UniProtKB=Q8ECL0	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_A1018\|UniProtKB=Q9KKT2	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC2652\|UniProtKB=Q8P7F9	Xanthomonas campestris	LDO
SALTY\|EnsemblGenome=STM2124\|UniProtKB=Q8ZNQ5	Salmonella typhimurium	LDO
ECOLI\|EnsemblGenome=BAA15926\|UniProtKB=P04395	Escherichia coli	LDO