PANTHER Gene Information

Gene Symbol(s):

MLH2

Organism:

Saccharomyces cerevisiae

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Gene Name:

DNA mismatch repair protein MLH2

Gene ID:

S000004025

Protein ID:

Q07980

Persistent Id:

PTN000008386

Alternate Ids:

YEAST:G3O-32194-MON(BioCyc)	Z73207(EMBL)
S000004025(SGD)	NM_001181922(refSeq)
850722(GeneID)	74627237(GI)
YLR035C(Ensembl)	D6VY37(AltAccession)
MutL protein homolog 2(Synonym)	DAA09353(EMBL-CDS)
MLH2(Symbol)	YLR035C_mRNA(Ensembl_TRS)
YLR035C(Ensembl_PRO)	MLH2_YEAST(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL (PTHR10073)
PANTHER Subfamily:	DNA MISMATCH REPAIR PROTEIN MLH2 (PTHR10073:SF44)
PANTHER GO-slim Molecular Function:	ATP hydrolysis activity
PANTHER GO-slim Biological Process:	mismatch repair
PANTHER GO-slim Cellular Component:	nuclear protein-containing complex
PANTHER protein class:	DNA metabolism protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, ATP binding, bubble DNA binding, heteroduplex DNA loop binding, ATP-dependent DNA damage sensor activity, mismatched DNA binding
GO BP Complete:	DNA repair, meiosis I cell cycle process, reciprocal meiotic recombination, mismatch repair
GO CC Complete:	nucleus, MutLbeta complex, mismatch repair complex, MutLalpha complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=7127\|UniProtKB=P40692	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000014743.5\|UniProtKB=H2QMA1	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000016342.3\|UniProtKB=G3RJQ3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000022533.4\|UniProtKB=F6YA63	Macaca mulatta	O
MOUSE\|MGI=MGI=101938\|UniProtKB=Q9JK91	Mus musculus	O
RAT\|RGD=620937\|UniProtKB=P97679	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000016758.5\|UniProtKB=F1MPG0	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000024222.4\|UniProtKB=I3LT92	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000000690.3\|UniProtKB=A0A9L0TRX2	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000001371.6\|UniProtKB=M3VWJ1	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845027002.1\|UniProtKB=A0A8I3PV01	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000013353.4\|UniProtKB=F7GA57	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000015305.3\|UniProtKB=A0A6I8N2N8	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010016109.1\|UniProtKB=A0A1D5P146	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010048.4\|UniProtKB=A0A803T1T8	Anolis carolinensis	O
XENLA\|Gene=mlh1.S\|UniProtKB=A0AUU1	Xenopus laevis	O
XENTR\|Gene=mlh1\|UniProtKB=A0A8J0QND8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000026320.1\|UniProtKB=A0A3B3HRQ1	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-1600\|UniProtKB=Q6PFL1	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000004851.1\|UniProtKB=W5MBR9	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000002563.4\|UniProtKB=F6UF57	Ciona intestinalis	O
BRAFL\|Gene=LOC118413111\|UniProtKB=A0A9J7KYK4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC588545\|UniProtKB=A0A7M7PEZ7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003373\|UniProtKB=Q9XU10	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG15306\|UniProtKB=A8XLW6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00090436\|UniProtKB=A0A2A6BPS0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0011659\|UniProtKB=A1Z7C1	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP012192\|UniProtKB=Q7Q013	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC005617\|UniProtKB=D6WX75	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308451\|UniProtKB=E9G300	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW007938\|UniProtKB=B7PRM3	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG190644\|UniProtKB=T1FS59	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g167864\|UniProtKB=A7S8W4	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG50100\|UniProtKB=B3RQF3	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_25323\|UniProtKB=A9UZ31	Monosiga brevicollis	O
EREGS\|EnsemblGenome=AGOS_AFR226C\|UniProtKB=Q753U9	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000200670\|UniProtKB=Q59SL0	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_C10032g\|UniProtKB=Q6CCE6	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00126\|UniProtKB=Q5BH54	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_5G11700\|UniProtKB=Q4WVD4	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU08309\|UniProtKB=V5INX3	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_08608\|UniProtKB=A7ETF2	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_08751\|UniProtKB=Q0UHL3	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPBC1703.04\|UniProtKB=Q9P7W6	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_01620\|UniProtKB=B6JYF8	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNE04630\|UniProtKB=Q5KG72	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_05208\|UniProtKB=A0A0D1E2U3	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_03468\|UniProtKB=E3JZN7	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_33018\|UniProtKB=F4NXZ4	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_129950\|UniProtKB=C4M5R1	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0287393\|UniProtKB=Q54KD8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_55923\|UniProtKB=F0ZP44	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_24_1420\|UniProtKB=Q4QAI9	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.8.6840\|UniProtKB=Q57TS9	Trypanosoma brucei	O
PLAF7\|EnsemblGenome=PF3D7_1117800\|UniProtKB=Q8IIJ0	Plasmodium falciparum	O
THAPS\|EnsemblGenome=THAPSDRAFT_263509\|UniProtKB=B8C801	Thalassiosira pseudonana	O
CHLRE\|EnsemblGenome=CHLRE_01g036050v5\|UniProtKB=A8HM54	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00071p00146130\|UniProtKB=U5DCN0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_83G00490\|UniProtKB=A0A0K9NNN2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma05_g18470\|UniProtKB=A0A804J5X1	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_000462mg\|UniProtKB=K3XEZ5	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3003G433300\|UniProtKB=C5XIK7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb362590\|UniProtKB=K7W1B0	Zea mays	O
ORYSJ\|EnsemblGenome=Os01g0958900\|UniProtKB=Q5JN46	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g61370v3\|UniProtKB=A0A0Q3REL0	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0323490\|UniProtKB=A0A8I6WWT6	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS3D02G507800\|UniProtKB=A0A3B6H6B2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G564100\|UniProtKB=A0A077S1H5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS7A02G140800\|UniProtKB=A0A3B6RAM4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G507500\|UniProtKB=A0A3B6H6Q2	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G500600\|UniProtKB=A0A3B6EQF2	Triticum aestivum	O
NELNU\|Gene=LOC104608305\|UniProtKB=A0A1U8B959	Nelumbo nucifera	O
SPIOL\|Gene=LOC110785518\|UniProtKB=A0A9R0JSN7	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr09g0403171\|UniProtKB=A0A251TZH5	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C100013820\|UniProtKB=A0A9R1WIJ7	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a002125mg\|UniProtKB=A0A022Q448	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_10334\|UniProtKB=A0A2G3A1X3	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc04g045660.3\|UniProtKB=A0A3Q7G2Q3	Solanum lycopersicum	O
TOBAC\|Gene=LOC107808834\|UniProtKB=A0A1S4BJ18	Nicotiana tabacum	O
EUCGR\|EnsemblGenome=EUGRSUZ_F02988\|UniProtKB=A0A059BTX7	Eucalyptus grandis	O
BRACM\|EnsemblGenome=Bra000674\|UniProtKB=M4C8Z6	Brassica campestris	O
ARATH\|TAIR=locus=2122388\|UniProtKB=Q9ZRV4	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107895080\|UniProtKB=A0A1U8IC38	Gossypium hirsutum	O
GOSHI\|Gene=LOC107920384\|UniProtKB=A0A1U8KXP6	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_036511\|UniProtKB=A0A061FKD1	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g005789mg\|UniProtKB=A0A067DV51	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_019G078700v3\|UniProtKB=A0A2K1WRA7	Populus trichocarpa	O
RICCO\|Gene_ORFName=RCOM_1331420\|UniProtKB=B9S712	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_04G254900\|UniProtKB=I1JZC3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_3g005810\|UniProtKB=G7J070	Medicago truncatula	O
JUGRE\|Gene=LOC108987673\|UniProtKB=A0A6P9EW81	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_6G016960\|UniProtKB=A0A0A0K8W6	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_1G555900\|UniProtKB=A0A251RIB1	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_421150\|UniProtKB=D8SEN7	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_408722\|UniProtKB=D8R9R6	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c10_9000\|UniProtKB=A0A2K1JYA9	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0086s0067\|UniProtKB=A0A2R6WIU2	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_003570040\|UniProtKB=A0A1Y1I943	Klebsormidium nitens	O
METAC\|EnsemblGenome=MA_0522\|UniProtKB=Q8TTB5	Methanosarcina acetivorans	O
HALSA\|EnsemblGenome=VNG_0159G\|UniProtKB=Q9HSM6	Halobacterium salinarum	O
CHLAA\|EnsemblGenome=Caur_1133\|UniProtKB=A9WJ86	Chloroflexus aurantiacus	O
CLOBH\|Gene_OrderedLocusName=CBO1799\|UniProtKB=A5I2S1	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0160\|UniProtKB=P0A3R2	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01273\|UniProtKB=Q93T05	Staphylococcus aureus	O
LISMO\|EnsemblGenome=CAC99482\|UniProtKB=Q8Y788	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_17050\|UniProtKB=P49850	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_3768\|UniProtKB=Q81A26	Bacillus cereus	O
THEMA\|EnsemblGenome=TM_0022\|UniProtKB=P74925	Thermotoga maritima	O
DEIRA\|EnsemblGenome=DR_1696\|UniProtKB=Q9RTR0	Deinococcus radiodurans	O
GLOVI\|Gene=mutL\|UniProtKB=Q7NL47	Gloeobacter violaceus	O
LEPIN\|EnsemblGenome=LA_1175\|UniProtKB=Q8F6X4	Leptospira interrogans	O
BACTN\|EnsemblGenome=BT_3851\|UniProtKB=Q8A120	Bacteroides thetaiotaomicron	O
CHLTR\|EnsemblGenome=CT_575\|UniProtKB=O84579	Chlamydia trachomatis	O
RHOBA\|EnsemblGenome=RB7883\|UniProtKB=Q7UMZ3	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_1578\|UniProtKB=O67518	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A2083\|UniProtKB=B5YIZ6	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_1078\|UniProtKB=B8E280	Dictyoglomus turgidum	O
FUSNN\|EnsemblGenome=FN0462\|UniProtKB=Q8RG56	Fusobacterium nucleatum	O
NEIMB\|EnsemblGenome=NMB1442\|UniProtKB=Q9JYT2	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU2001\|UniProtKB=Q74BP0	Geobacter sulfurreducens	O
BRADU\|EnsemblGenome=BAC52758\|UniProtKB=Q89DE6	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_1083\|UniProtKB=Q83CM9	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0067\|UniProtKB=P44494	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_0601\|UniProtKB=Q8EJ70	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0345\|UniProtKB=Q9KV13	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC2298\|UniProtKB=Q8P8E4	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA4946\|UniProtKB=Q9HUL8	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM4359\|UniProtKB=P14161	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_0527\|UniProtKB=Q8ZIW4	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE78171\|UniProtKB=P23367	Escherichia coli	O